Dinuclear silver(I)-N-heterocyclic carbene complexes of N-allyl substituted (benz)imidazol-2-ylidenes with pyridine spacers: synthesis, crystal structures, nuclease and antibacterial studies

Silver(I) complexes of mono- and bidentate N-heterocyclic carbene ligands: Synthesis, crystal structures, and in vitro antibacterial and anticancer studies

“…In the complex spectra, the coordination of the benzimidazol-2-ylidene units to the Ag centres was fully evidenced by the appearance of two sharp absorption bands at ca. 1590 and 1105 cm -1 assigned for the aforementioned functionalities, which suffered a negative shift of about 15-20 cm -1 [19]. Apart from this the IR spectra of compounds 4-9 also evidenced the sharp absorption bands in the range ca.…”

Synthesis and catalytic activity of N-heterocyclic carbene metal carbonyl complexes based on 1-[2-(pyrazol-1-yl)phenyl]imidazole

“…Yield: 63 %. 1 Synthesis of L 0 Ru 4 (CO) 10 (6) A mixture of DPBCl (0.18 g, 0.50 mmol) and Ag 2 O (58 mg, 0.25 mmol) in CH 2 Cl 2 (10 mL) was stirred for 24 h at room temperature in the absence of light. The solvent was removed under reduced pressure; then, Ru 3 (CO) 12 (0.11 g, 0.17 mmol) and THF (20 mL) were added.…”

“…The catalytic activity of these NHC-transition metal complexes can be readily fine-tuned through the structural modification of the NHC ligands. Recent investigations show that donor-functionalized NHC-metal complexes can generate the active catalytic species through the reversible coordination/dissociation process of the donor functions from the metal centers, which accelerate the rapid development of various donor-functionalized NHC ligands, such as N-, P-, O-, S-functionalized NHCs [5][6][7][8][9][10]. In the family of N-functionalized NHCs, pyrazolylfunctionalized NHCs have drawn much attention owing to the coordination versatility of pyrazole-based ligands and the catalytic activity of their complexes [11][12][13][14][15][16][17][18].…”

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

“…[60] Finally, the test compounds can also degrade the plasmid DNA and/or RNA. [61,62] The gel electrophoresis images are shown in Fig. 4.…”

“…The plasmid DNA is totally degraded, leading to the loss of the associated bands on the gel. [61] The nuclease activity of 9 relative to the other analogues as evident from the complete degradation of DNA and RNA could be due to the presence of an electron-withdrawing group in the complex: the positive charge of the Ag ion increases, and this enhances the ability of the Ag ion to interact with DNA. This observation suggests that these Ag(I)-NHC complexes have potential to cleave nucleic acids by a non-oxidative mechanism, possibly by a hydrolytic path which has yet to be clarified conclusively.…”