Dinuclear manganese(II) complexes of hexaazamacrocycles bearing N-benzoylated pendant separated by aromatic spacers: Antibacterial, DNA interaction, cytotoxic and molecular docking studies

Arthi, P.; Shobana, Shanmugam; Srinivasan, Pappu; Prabhu, D.; Chinnasamy, Arulvasu; Rahiman, A. Kalilur

doi:10.1016/j.jphotobiol.2015.09.026

Cited by 17 publications

(8 citation statements)

References 61 publications

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“…Against bacterial strains, such as E. coli, B. subtilis, and S. aureus, MICs were significantly low ranging from 0.0625-1.000 and 0.5-19 µg/mL. In 2015, P. Arthi and coworkers reported a series of pendant-armed Schiff base hexaaza macrocycles manganese(II) complexes by the condensation of equimolar amounts of terephthalaldehyde and N,N-bis(2-aminoethyl)benzamide derivatives in the presence of Mn(ClO 4 ) 2 •6H 2 O as a templating agent (15, Figure 3) [55]. In comparison to the standard drug, ciprofloxacin, the complexes showed good activities against both Gram-negative (K. pneumoniae, P. aeruginosa, V. alginolyticus, V. cholerae and V. harveyi) and Gram-positive (S. aureus and S. mutans) bacterial strains.…”

Section: Manganese Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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Section: Manganese Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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“…The broadness may be due to intramolecular hydrogen bonding. The appearance of a band at ca 815 cm −1 implies the rocking mode of water, which clearly ratifies the coordination of water molecule to metal centre . Further, complex formation is strongly evidenced by the disappearance of carbonyl ( ca 1680 cm −1 ) and N – H of primary amine (2922–2956 cm −1 ) stretching frequencies of the precursors with the appearance of a sharp band in the region 1632–1666 cm −1 corresponding to ν(CN), as a consequence of Schiff base condensation.…”

Section: Resultsmentioning

confidence: 78%

Antioxidant, DNA interaction, molecular docking and cytotoxicity studies of aminoethylpiperazine‐containing macrocyclic binuclear copper(II) complexes

Karthick¹,

Karthikeyan

Korrapati

et al. 2016

Applied Organom Chemis

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A series of new macrocyclic binuclear copper(II) complexes of the type [Cu2L1–5(ClO4)](ClO4) (1–5) were synthesized by template condensation between precursor compounds 2,6‐bis(4‐aminoethylpiperazin‐1‐ylmethyl)‐4‐substituted phenols and 2,6‐diformyl‐4‐substituted phenols. The synthesized precursors and complexes were characterized using regular physicochemical techniques. The rate constant values obtained for the hydrolysis of 4‐nitrophenylphosphate were in the range 1.83 × 10−2–4.19 × 10−2 min−1. Antioxidant studies against 2,2′‐diphenyl‐1‐picrylhydrazyl revealed the antioxidant potency of the synthesized complexes. Binding studies of the complexes with calf thymus DNA were conducted using electronic, viscometric and voltammetric techniques, and the obtained results suggested a non‐covalent groove mode of binding. The oxidative cleavage of pBR322 DNA in the presence of co‐reactant H2O2 and radical scavengers showed single strand scission and involvement of H2O2 radical in the cleavage process. Molecular docking studies were performed to insert complexes into the crystal structures of 1BNA and VEGFR kinase at active sites to determine the possible binding mode and predominant binding interactions. In vitro cytotoxicity of the complexes was tested against human epidermoid carcinoma cells (A431) by MTT assay, which revealed the effective anticancer activity of the complexes. Live cell and fluorescent imaging of A431 cells showed that the complexes induce cell death through apoptosis.

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“…Generally, the d 5 system with I=5/2 of 55 Mn nuclei displays a characteristic hyperfine pattern comprising six lines. But the occurrence of distorted orientation from regular symmetry around the Mn(II) center leads to anisotropic resonance resulting in broad‐spectrum instead of hyperfine splitting [42–43] . Hence, the obtained EPR signal indicates the distorted orientation of the surrounding of the Mn(II) center in Mn 1 .…”

Section: Resultsmentioning

confidence: 92%

Water Oxidation by a Neoteric Dinuclear Mn(II) Electrocatalyst in Aqueous Medium

Raj

Padhi

2022

Eur J Inorg Chem

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The employment of manganese complexes towards electrocatalytic water oxidation has gained immense interest among the scientific communities. In this present study, the reaction of Mn(CH 3 COO) 2 •4H 2 O with the novel ligand (2-([2,2':6',2"-terpyridin]-4'-yl)quinoline-8-ol) (8hq-tpy) affords a dinuclear manganese complex, [Mn II (8hq-tpy)(H 2 O)] 2 (PF 6 ) 2 (Mn 1). Various spectroscopic techniques have been implemented for characterization purposes, and Mn 1 is employed as electrocatalysts towards water oxidation catalysis in the aqueous medium. Electrocatalytic responses in the aqueous medium at pH 6.0 lead to the electrodeposition of heterogeneous species (MnO X ) which enables the oxidation event at an applied potential of 1.24 V vs. NHE with O 2 liberation of 50.2 μmol/L. The XPS analysis performed after executing bulk electrolysis, provide evidence for the generation of Mn IV = O as the active species formed by the catalyst precursor complex Mn 1, contributing to O 2 evolution during the electrocatalytic water oxidation process.

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Dinuclear manganese(II) complexes of hexaazamacrocycles bearing N-benzoylated pendant separated by aromatic spacers: Antibacterial, DNA interaction, cytotoxic and molecular docking studies

Cited by 17 publications

References 61 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Antioxidant, DNA interaction, molecular docking and cytotoxicity studies of aminoethylpiperazine‐containing macrocyclic binuclear copper(II) complexes

Water Oxidation by a Neoteric Dinuclear Mn(II) Electrocatalyst in Aqueous Medium

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