Dinuclear bismuth(III) complex constructed by isoniazid‐derived Schiff base: Synthesis, crystal structure, and biological activity

Li, Chuanhua; Ji, Meng‐Han; Zhang, Kai‐Wen; Sun, Shou‐Ying; Jiang, Jian‐Hong

doi:10.1002/aoc.6876

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…Considering the structural aspects in this case, the metal center, some dinuclear Bi 3+ complexes with potential anticancer properties deserve attention. For example, Li et al recently prepared seven dinuclear Bi 3+ complexes bearing N,O,N-chelating Schiff-base ligands (57)(58)(59)(60)(61)(62) that revealed significative cytotoxic activity on human gastric cancer SNU-16 cells [142,150].…”

Section: Bismuth(iii) Complexes Bearing No-donor Ligandsmentioning

confidence: 99%

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

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Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess synergistic activity, making them ideal for multiple therapy regimens and overcoming bacterial resistance. Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. As a result, there is a growing interest in developing new bismuth compounds and approaches to overcome this challenge. Considering the beneficial properties of bismuth and the importance of discovering new drugs, this review focused on the last decade’s updates involving bismuth compounds, especially those with potent activity and low toxicity, desirable characteristics for developing new drugs. In addition, bismuth-based compounds with dual activity were also highlighted, as well as their modes of action and structure–activity relationship, among other relevant discoveries. In this way, we hope this review provides a fertile ground for rationalizing new bismuth-based drugs.

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Section: Bismuth(iii) Complexes Bearing No-donor Ligandsmentioning

confidence: 99%

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

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“…Li et al, (2022) [ 91 ] described a study on the binuclear complex of bismuth(III) with ( E )- N’ -(2-hydroxy-4-methoxybenzylidene)isonicotinohydrazide ( 30 ) and the antimicrobial activity against two Gram-positive ( S. aureus Newman and B. subtilis CMCC63501) and two Gram-negative ( E. coli AB1157 and P. aeruginosa PA01) bacteria obtained from the China General Microbiological Culture Collection Center (CGMCC, Beijing, China) in comparison to three standards, namely, vancomycin, kanamycin, and tetracycline. The complex showed high activity against S. aureus vancomycin (MIC = 2 μg/mL and 1.54 μM), similar to that of vancomycin (MIC = 2 μg/mL and 1.38 μM).…”

Section: Binuclear Sbs Complexesmentioning

confidence: 99%

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Sinicropi

Ceramella

Iacopetta

et al. 2022

IJMS

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Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

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Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

Li,

Qiu,

et al. 2024

Applied Organom Chemis

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Two new Schiff‐base bismuth (III) complexes were prepared by an equivalent reaction between Schiff‐base ligand and Bi (NO3)3•5H2O with the assistance of Mannitol. The chemical structures of the two complexes were characterized by spectroscopic studies (FT‐IR, NMR, and MS), elemental analysis, and single‐crystal X‐ray diffraction. The ligand‐to‐metal ion ratio was found to be 1:1 in the complexes. During the formation of the complexes, Schiff bases changed from the amidic forms to the iminol forms, and the resulting tautomers could coordinate with bismuth (III) ions to produce dinuclear BiIII complexes(1a and 2a). Structural analyses showed that each Bi (III) ion held a distorted capped octahedron geometry with a seven‐coordinate mode in two complexes. Screening in vitro biological activities revealed that two bismuth (III) complexes exhibited much higher antimicrobial and cytotoxic activity than their parent ligands. The cytotoxic activity of the complex(1a) was close to that of the known anticancer drug (Doxorubicin) by evaluating against SGC7901 cells, with the IC50 value 0.59 μM. The complex(1a) could effectively induce SGC7901 cell apoptosis and its oral acute toxicity for LD50 value was found to be 576 mg kg−1. The content of bismuth (III) in mitochondria was higher than that in the nucleus.

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Dinuclear bismuth(III) complex constructed by isoniazid‐derived Schiff base: Synthesis, crystal structure, and biological activity

Cited by 4 publications

References 48 publications

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide‐derived Schiff bases

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