Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD

Zhang, Yaxin; Gu, Yin; Chen, Yi-Hao; Huang, Zhiyong; Li, Mei; Jiang, Weihao; Chen, Jiahui; Rao, Wenting; Luo, Shangfei; Chen, Yuyao; Chen, Junqi; Li, Lijun; Jia, Yuhua; Liu, Menghua; Zhou, Fenghua

doi:10.1016/j.jep.2020.113436

Cited by 56 publications

(31 citation statements)

References 46 publications

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“…Atherosclerosis is characterized by visible atherosclerotic lesions in the artery walls, especially in the coronary artery and aorta. These lesions primarily occur due to excessive lipid deposition [ 36 ]. Therefore, atherosclerosis originates from the passive diffusion of circulating LDL through endothelial junctions into the vessel intima [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial

Liu

Yang

et al. 2022

J Transl Med

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Background High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in female university students with normal weight obesity (NWO). Thus, this study aimed to investigate the effects of HIIT on the body composition, heart rate (HR), blood pressure (BP), blood lipids metabolism as well as the novel parameters of propensity for AS (arterial velocity pulse index [AVI], arterial pressure volume index [API]) for female university students with NWO. Methods Forty female university students with NWO were randomly assigned to control group (n = 20) and HIIT group (3 bouts of 9‑min intervals at 90% of the maximal heart rate [HRmax], interspersed by 1 min rest, 5 days a week, n = 20). Tests were performed before and after 4 weeks of training. Repeated measures ANOVA and simple effect test analysis were used to analyze dependent variable changes. Results After 4 weeks HIIT statistically significantly improved the body composition by decreasing the body mass index, body fat percent, total body fat mass (BFM), BFM of left arm, measured circumference of left arm, and obesity degree, and increasing the total body skeletal muscle mass, protein content, total body water, fat free mass, body cell mas, and InBody score. HIIT also statistically significantly decreased the HR and BP. As for the lipid profile, HIIT obviously ameliorated the blood lipids metabolism by decreasing the levels of total cholesterol (TC), triglyceride, low-density lipoprotein, and TC/HDL, and increasing the levels of high-density lipoprotein (HDL). In addition, the AVI and API were markedly decreased via HIIT intervention. Conclusions HIIT produced significant and meaningful benefits for body composition, HR, BP, and blood lipids metabolism, and could decrease AS in female university students with NWO. This suggests that HIIT may effectively reduce the risk of arteriosclerosis and protect the cardiovascular function for female university students with NWO. Trial registration ChiCTR2100050711. Registered 3 September 2021. Retrospectively registered.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, atherosclerosis originates from the passive diffusion of circulating LDL through endothelial junctions into the vessel intima [ 37 ]. Two of the most representative indicators are elevated levels of TC and LDL [ 36 ]. The reduction in LDL can further lower cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 99%

Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial

Liu

Yang

et al. 2022

J Transl Med

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“…In recent years, additional traditional Chinese medicines have been observed to have cholesterol-lowering effects, including aloe-emodin ( Su et al, 2020 ), apigenin ( Wu et al, 2021b ), Dingxin recipe IV ( Zhang et al, 2021 ), and ZeXie decoction ( Wu et al, 2021a ). The mechanisms of some of these medicines involve SREBP2 transcription and maturation processes.…”

Section: Discussionmentioning

confidence: 99%

Intracellular Cholesterol Synthesis and Transport

Shi

Chen

Zou

et al. 2022

Front. Cell Dev. Biol.

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Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

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“…Therefore, atherosclerosis originates from the passive diffusion of circulating LDL through endothelial junctions into the vessel intima [38]. One of the most representative is the elevated levels of TC and LDL [37]. The reduction of LDL can further lower cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 99%

Effects of High-Intensity Interval Training on Improving Arterial Stiffness in Chinese Normal Weight Obese Female University Students: A Pilot Randomized Controlled Trial

Zhu

Yang

et al. 2021

Preprint

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Background: High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in normal weight obesity (NWO) females. Thus, this study investigated the changes of body composition, heart rate (HR), blood pressure (BP), blood lipids as well as the parameters of propensity for AS (arterial velocity pulse index (AVI) and arterial pressure volume index (API)).Methods: Forty NWO female university students were randomly assigned to the control group (n=20) or the HIIT group (30 minutes at 90% HRmax, n=20). The participants in HIIT group accepted a four-week HIIT intervention for five days a week. The above parameters of body composition, cardiometabolic biomarkers, lipid profile, and AS were assessed before and after the HIIT intervention. Results: HIIT significantly improved the body composition in decreasing the BMI (p=0.001), BF% (p<0.001), BFM (p<0.001), LBFM (p<0.001), LMC (p=0.016), and Obesity degree (p=0.001), and increased the SMM (p=0.020), Protein content (p=0.035), TBW (p=0.017), FFM (p=0.019), BCM (p=0.020), and Inbody score (p<0.001). HIIT also affected the cardiometabolic biomarkers by decreasing the HR (p=0.001), SBP (p<0.001), and DBP (p<0.001). As for the lipid profile, HIIT obviously ameliorated the blood lipids metabolism by decreasing the levels of TC (p=0.001), TG (p<0.001), LDL (p<0.001), and TC/HDL (p<0.001), and increasing the levels of HDL (p<0.001). In addition, the AS was improved by HIIT intervention through decreasing the AVI (p<0.001) and API (p<0.001).Conclusions: Our results provided herein demonstrate that this pattern of a 4-week HIIT had a positive impact on physical fitness in the aspect of body composition, lipid profile, and cardiovascular function in NWO female university students.Trial registration: ChiCTR2100050711. Registered 3 September 2021. Retrospectively registered.

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Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD

Cited by 56 publications

References 46 publications

Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial

Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial

Intracellular Cholesterol Synthesis and Transport

Effects of High-Intensity Interval Training on Improving Arterial Stiffness in Chinese Normal Weight Obese Female University Students: A Pilot Randomized Controlled Trial

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