Diminutive polyps: histopathology, spatial distribution, and clinical significance

Tedesco, Francis J.; Hendrix, John C.; Pickens, Chip; Brady, Patrick; Mills, Luther R.

doi:10.1016/s0016-5107(82)72954-2

Cited by 105 publications

(19 citation statements)

References 10 publications

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“…In an autopsy study two thirds of polyps less than 5 mm were adenomatous [1]. In a colonoscopic study in which 329 diminutive polyps were removed, there was a slight preponderance of neoplastic polyps (49 v 37%) [25]. We believe that even at the lowest reported range (i.e., 10%), the risk that a diminutive polyp is neoplastic is unacceptably high and the polyp should be examined histologically and patients followed up accordingly.…”

Section: Discussionmentioning

confidence: 92%

The changed histologic paradigm of colorectal polyps

2001

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Adenomatous polyps outnumber hyperplastic polyps 7:1, even in the distal colon. Even small polyps seen during colonoscopy should be removed and subjected to histologic analysis because of the advisability of follow-up examinations of patients with neoplastic polyps. The increase in the incidence of neoplastic polyps beginning at the age of 50 years supports the need for colonoscopy in these individuals.

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Section: Discussionmentioning

confidence: 92%

The changed histologic paradigm of colorectal polyps

2001

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“…As seen in other studies, our results showed that virtual colonoscopy fared poorly in detecting individual lesions and patients with lesions 5 mm or less. However, the prevalence of malignancy in diminutive polyps is extremely small, approximating 0.25% [22][23][24] . Previous study showed virtual colonoscopy more acceptable in terms of overall convenience [11] .…”

Section: Discussionmentioning

confidence: 99%

Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

Jun¹

2007

WJG

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AIM:To examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy (CTC) as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS:To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the 'colon polyp survey group'. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients (M:F 29:18, mean age 53.8 years), which we call the 'CT colonoscopy group'. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS:Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the incidence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION:The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

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“…Many organizations, including the International Endoscopic Society, do not recommend follow-up for patients with these lesions. 18,19 However, studies do indicate that they share some histochemical changes with CRC (increased expression of carcinoembryonic antigen, reduced secretion of O-acylated sialomucin, and altered activity of cytoplasmic enzymes) and that their epidemiology may parallel that of adenomas. 19 Perhaps if immunosuppression can induce malignant conversion in adenomas, it could also do so for hyperplastic polyps.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 However, studies do indicate that they share some histochemical changes with CRC (increased expression of carcinoembryonic antigen, reduced secretion of O-acylated sialomucin, and altered activity of cytoplasmic enzymes) and that their epidemiology may parallel that of adenomas. 19 Perhaps if immunosuppression can induce malignant conversion in adenomas, it could also do so for hyperplastic polyps. In our study, we found that 15 percent of the transplant group and 11 percent of the control group developed adenomas with only hyperplastic polyps on their initial examination.…”

Section: Discussionmentioning

confidence: 99%

The Role of Endoscopic Colon Surveillance in the Transplant Population

Parikshak¹,

Pawlak²,

Eggenberger³

et al. 2002

Diseases of the Colon &Amp; Rectum

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Because of an equivalent incidence of adenomatous polyps compared with the general population, current screening criteria should be used in patients posttransplant. Transplant patients are not more likely to develop metachronous polyps than the general population. Therefore, posttransplant polyp surveillance should not be more frequent than currently recommended for nontransplant patients with adenomatous polyps.

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Diminutive polyps: histopathology, spatial distribution, and clinical significance

Cited by 105 publications

References 10 publications

The changed histologic paradigm of colorectal polyps

The changed histologic paradigm of colorectal polyps

Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

The Role of Endoscopic Colon Surveillance in the Transplant Population

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