Diminished Nap Effects on Memory Consolidation Are Seen Under Oral Contraceptive Use

Genzel, Lisa; Bäurle, Anna; Potyka, Alina; Wehrle, R.; Adamczyk, Marek; Frieß, Elisabeth; Steiger, Axel; Dresler, Martin

doi:10.1159/000369022

Cited by 24 publications

(21 citation statements)

References 67 publications

(113 reference statements)

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“…One prior study examined sleep-dependent learning in a non-declarative visual learning task in men and women (McDevitt et al, 2014), without considering menstrual cycle effects in the female subjects. In addition, the only two published studies that investigated the interaction between sex steroid levels and sleep-related memory consolidation in women, only focused on spindle activity (Genzel et al, 2012;Genzel et al, 2015). Unlike the present study, prior results report increased spindles in females compared with males (Huupponen et al, 2002, Carrier et al, 2001.…”

Section: Discussioncontrasting

confidence: 79%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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Section: Discussioncontrasting

confidence: 79%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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“…Our algorithm was validated with data from an earlier study (Genzel et al, 2014 ). In brief, 20 participants (10 male, age 20–30 years) had two nap sessions in the sleep laboratory separated by at least 4 weeks, one with and one without previous learning experience.…”

Section: Methodsmentioning

confidence: 99%

“…In brief, 20 participants (10 male, age 20–30 years) had two nap sessions in the sleep laboratory separated by at least 4 weeks, one with and one without previous learning experience. For more details regarding study design and participants please see Genzel et al ( 2014 ). Eighteen naps from n = 10 subjects were randomly selected and our algorithm was compared with the SIESTA algorithm of Anderer et al ( 2005 ) and with a human scorer.…”

Section: Methodsmentioning

confidence: 99%

Automatic Sleep Spindle Detection and Genetic Influence Estimation Using Continuous Wavelet Transform

Adamczyk

Genzel

Dresler

et al. 2015

Front. Hum. Neurosci.

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Mounting evidence for the role of sleep spindles in neuroplasticity has led to an increased interest in these non-rapid eye movement (NREM) sleep oscillations. It has been hypothesized that fast and slow spindles might play a different role in memory processing. Here, we present a new sleep spindle detection algorithm utilizing a continuous wavelet transform (CWT) and individual adjustment of slow and fast spindle frequency ranges. Eighteen nap recordings of ten subjects were used for algorithm validation. Our method was compared with both a human scorer and a commercially available SIESTA spindle detector. For the validation set, mean agreement between our detector and human scorer measured during sleep stage 2 using kappa coefficient was 0.45, whereas mean agreement between our detector and SIESTA algorithm was 0.62. Our algorithm was also applied to sleep-related memory consolidation data previously analyzed with a SIESTA detector and confirmed previous findings of significant correlation between spindle density and declarative memory consolidation. We then applied our method to a study in monozygotic (MZ) and dizygotic (DZ) twins, examining the genetic component of slow and fast sleep spindle parameters. Our analysis revealed strong genetic influence on variance of all slow spindle parameters, weaker genetic effect on fast spindles, and no effects on fast spindle density and number during stage 2 sleep.

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“…We hypothesized that odor-induced memory reactivation during SWS enhances explicit sequence knowledge. Since previous findings also suggest that sleep affects memory consolidation processes differently in men and women (Genzel et al, 2012 , 2014a ), we additionally explored possible sex differences in the odor reactivation effect.…”

Section: Introductionmentioning

confidence: 99%

Increasing Explicit Sequence Knowledge by Odor Cueing during Sleep in Men but not Women

Diekelmann

Born

Rasch

2016

Front. Behav. Neurosci.

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Sleep consolidates newly acquired memories. Beyond stabilizing memories, sleep is thought to reorganize memory representations such that invariant structures, statistical regularities and even new explicit knowledge are extracted. Whereas increasing evidence suggests that the stabilization of memories during sleep can be facilitated by cueing with learning-associated stimuli, the effect of cueing on memory reorganization is less well understood. Here we asked whether olfactory cueing during sleep enhances the generation of explicit knowledge about an implicitly learned procedural memory task. Subjects were trained on a serial reaction time task (SRTT) containing a hidden 12-element sequence in the presence of an odor. During subsequent sleep, half of the subjects were re-exposed to the odor during periods of slow wave sleep (SWS), while the other half received odorless vehicle. In the next morning, subjects were tested on their explicit knowledge about the underlying sequence in a free recall test and a generation task. Although odor cueing did not significantly affect overall explicit knowledge, differential effects were evident when analyzing male and female subjects separately. Explicit sequence knowledge, both in free recall and the generation task, was enhanced by odor cueing in men, whereas women showed no cueing effect. Procedural skill in the SRTT was not affected by cueing, neither in men nor in women. These findings suggest that olfactory memory reactivation can increase explicit knowledge about implicitly learned information, but only in men. Hormonal differences due to menstrual cycle phase and/or hormonal contraceptives might explain the lacking effect in women.

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Diminished Nap Effects on Memory Consolidation Are Seen Under Oral Contraceptive Use

Cited by 24 publications

References 67 publications

The effect of sex and menstrual phase on memory formation during a nap

The effect of sex and menstrual phase on memory formation during a nap

Automatic Sleep Spindle Detection and Genetic Influence Estimation Using Continuous Wavelet Transform

Increasing Explicit Sequence Knowledge by Odor Cueing during Sleep in Men but not Women

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