Dimeric bisindole alkaloids from the stem bark of Strychnos nux-vomica L.

Jonville, Marie-Caroline; Dive, Georges; Angenot, Luc; Béro, Joanne; Tits, Monique; Ollivier, Évelyne; Frédérich, Michel

doi:10.1016/j.phytochem.2012.11.002

Cited by 24 publications

(52 citation statements)

References 17 publications

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“…ese longicaudatine-type alkaloids display antiplasmodial activity against both the chloroquine-resistant and chloroquinesensitive strains. e most interesting was compound 6 with an IC 50 value at around 10 μM [23]. Muganza et al [24] reported the isolation of two known indolosesquiterpene alkaloids, polyalthenol (7) and N-acetyl-polyveoline (5), from various parts of the tree Greenwayodendron suaveolens (Engl.…”

Section: Terpenoidal and Steroidalmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

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Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.

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Section: Terpenoidal and Steroidalmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

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“…Each compound, fraction and extract was applied in a series of eight twofold dilutions (final concentrations ranging from 0.8 to 100 lg/ml for an extract and from 0.08 to 10 lg/ml for a pure substance) on two rows of a 96-well microplate and were tested in triplicate (n = 3). Parasite growth was estimated by determination of lactate dehydrogenase activity as described previously in Jonville et al [14] Artemisinin (98%; Sigma-Aldrich, Darmstadt, Germany) was used as positive control.…”

Section: Antiplasmodial Activity Assaymentioning

confidence: 99%

In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

Alson

Jansen

Cieckiewicz

et al. 2018

Journal of Pharmacy and Pharmacology

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“…44). 287 Four new aspidosperma-aspidosperma-type bisindole alkaloids, 3-oxovoafrine (915), and voacandimines A (916), B (917), and C (918), were isolated from the seeds and root bark of Voacaga africana, a tropical tree distributed in Africa (Fig. 45).…”

Section: Bisindole Alkaloidsmentioning

confidence: 99%