The effects of oral health conditions on physical and psychosocial dimensions have been a matter of interest for several authors over the last decades. Nevertheless, literature lacks studies that address the relationship between the oral health-related quality of life (OHRQoL) and emotions. The present study aimed to investigate the psychological impact of oral disorders on people's emotional well-being, with a particular attention to gender and age differences. Two hundred twenty-nine dental patients in care at private dental clinics were individually tested. One hundred thirty of them were females (56.8%) and 99 males (43.2%), aged between 18 and 83 years (M = 38.11; SD = 16.7). For the evaluation, the Profile of Mood States (POMS) and the Oral Health Impact Profile (OHIP-14) were used. Data were analyzed using Pearson's correlations, the ANOVA, and the Kruskal-Wallis test. OHRQoL showed several correlations with all the emotions explored, overcoming the wellknown relationship with anxiety and depression (p < .05). The degree of OHRQoL produced differences on mood states, which could appear normal, moderately altered, or psychopathological (p < .03). Furthermore, in different life stages, patients showed specific OHRQoL and emotions.