Dilution and amplification effects in Lyme disease: Modeling the effects of reservoir-incompetent hosts on Borrelia burgdorferi sensu stricto transmission

Ratti, Vardayani; Winter, Jonathan M.; Wallace, Dorothy

doi:10.1016/j.ttbdis.2021.101724

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…en un número limitado de pequeños roedores, deben considerarse en las investigaciones otros factores que permiten la circulación y establecimiento de la bacteria como son la diversidad amplia de especies de mamíferos y de vectores y también las condiciones climáticas que ayudan a la reproducción y mantenimiento de los mamíferos reservorios y vectores en los sitios de estudio [26]. Recientemente, Ratti y col. [22] encontraron en estudios de modelaje que los venados (Odocoileus virginianus) tienen un efecto de dilución de B. burgdorferi s.s. A medida que las poblaciones de reservorios incompetentes (como los venados) se presentan en una región y los reservorios competentes (roedores) se distribuyen en grandes distancias, la prevalencia del agente disminuye, tanto en las ninfas como en los adultos vectores y, por lo tanto, su transmisión. Este efecto también ha sido demostrado en condiciones de campo [13].…”

Section: Resultados Y Discusionunclassified

Frecuencia de Borrelia burgdorferi sensu lato y Leptospira spp. en pequeños roedores de Yucatán, México

et al. 2022

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Las bacterias espiroquetas Borrelia burgdorferi sensu lato (s.l.) y Leptospira spp. ocasionan la borreliosis de Lyme y leptospirosis, respectivamente, ambas enfermedades zoonóticas de importancia en salud pública. En sus respectivos ciclos epidemiológicos, los pequeños roedores son hospedadores accidentales y reservorios naturales de estas bacterias. Se capturaron pequeños roedores en las comunidades marginadas de Chan San Antonio y Sucopó, ubicadas en la zona oriente de Yucatán, México. Se tomaron muestras de vejiga, oreja y riñón y se utilizaron para la extracción del ácido desoxirribonucleico (ADN) genómico que se empleó para la búsqueda de ADN de B. burgdorferi s.l. y Leptospira spp. Se capturaron un total de 82 roedores de las especies Mus musculus, Rattus rattus y Heteromys gaumeri. En las muestras estudiadas no se encontró ADN de B. burgdorferi s.l. La infección con Leptospira spp. fue de 1,21 % (1/82). El único individuo positivo perteneció a la especie M. musculus. Se concluye que, si bien la frecuencia de infección con Leptospira spp. fue baja y que no se encontró evidencia de ADN de B. burgdorferi s.l. en la población estudiada de roedores, no puede descartarse su participación como hospederos accidentales o reservorios en los respectivos ciclos de transmisión de los géneros bacterianos evaluados.

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Section: Resultados Y Discusionunclassified

Frecuencia de Borrelia burgdorferi sensu lato y Leptospira spp. en pequeños roedores de Yucatán, México

et al. 2022

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“…In contrast, mechanistic modeling that aims to capture specific cause-effect relationships in disease development and transmission (Cheng et al, 2016) can compensate for the drawbacks of statistical methods. For example, mechanistic models developed for LD have incorporated hosts, vectors, and their interactions, and can thereby project influences of temperature changes on population dynamics of ticks in various life stages (Wu et al, 2015), as well as quantify host community impacts on LD transmission (Lou et al, 2014;Ratti et al, 2021). Mechanistic modeling, however, also has drawbacks, such as requirements of large amounts of observation data with a certain resolution for application to specific locations, for which such data often do not exist (Lou et al, 2014;Ogden et al, 2005Ogden et al, , 2013Ratti et al, 2021).…”

Section: Quantitative Study Methodsmentioning

confidence: 99%

Infectious Disease Sensitivity to Climate and Other Driver‐Pressure Changes: Research Effort and Gaps for Lyme Disease and Cryptosporidiosis

Kalantari

Destouni

2023

GeoHealth

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Climate sensitivity of infectious diseases is discussed in many studies. A quantitative basis for distinguishing and predicting the disease impacts of climate and other environmental and anthropogenic driver‐pressure changes, however, is often lacking. To assess research effort and identify possible key gaps that can guide further research, we here apply a scoping review approach to two widespread infectious diseases: Lyme disease (LD) as a vector‐borne and cryptosporidiosis as a water‐borne disease. Based on the emerging publication data, we further structure and quantitatively assess the driver‐pressure foci and interlinkages considered in the published research so far. This shows important research gaps for the roles of rarely investigated water‐related and socioeconomic factors for LD, and land‐related factors for cryptosporidiosis. For both diseases, the interactions of host and parasite communities with climate and other driver‐pressure factors are understudied, as are also important world regions relative to the disease geographies; in particular, Asia and Africa emerge as main geographic gaps for LD and cryptosporidiosis research, respectively. The scoping approach developed and gaps identified in this study should be useful for further assessment and guidance of research on infectious disease sensitivity to climate and other environmental and anthropogenic changes around the world.

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“…The process based model used to investigate multiple intervention strategies is based on a prior model of the tick vector for Lyme Disease, Ixodes scapularis [ 24 , 25 , 26 ]. Dynamic compartments for maturing, questing, and feeding larvae, nymphs and adults were included for both infected and uninfected populations, as well as population dynamics of host species, represented as a system of ordinary differential equations.…”

Section: Methodsmentioning

confidence: 99%

“…The model developed in this study is based on prior models of Ixodes scapularis and revised to include temperature and humidity responses, and other development parameters particular to R. sanguineus , and include the appropriate host structure [ 24 , 25 , 26 ]. Ixodes sp.…”

Section: Introductionmentioning

confidence: 99%

Modeling of Control Efforts against Rhipicephalus sanguineus, the Vector of Rocky Mountain Spotted Fever in Sonora Mexico

Álvarez

Trejo

Ratti

et al. 2022

Insects

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Rocky Mountain spotted fever (RMSF) is a significant health problem in Sonora, Mexico. The tick vector, Rhipicephalus sanguineus, feeds almost exclusively on domestic dogs that, in this region, also serve as the reservoir for the tick-borne pathogen, Rickettsia rickettsii. A process-based mathematical model of the life cycle of R. sanguineus was developed to predict combinations of insecticidal dog collars and long-lasting insecticidal wall treatments resulting in suppression of indoor tick populations. Because of a high burden of RMSF in a rural community near the Sonora state capital of Hermosillo, a test area was treated with a combination of insecticidal dog collars and long-lasting insecticidal wall treatments from March 2018 to April 2019, with subsequent reduction in RMSF cases and deaths. An estimated 80% of the dogs in the area had collars applied and 15% of the houses were treated. Data on tick abundance on walls and dogs, collected during this intervention, were used to parameterize the model. Model results show a variety of treatment combinations likely to be as successful as the one carried out in the test community.

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Dilution and amplification effects in Lyme disease: Modeling the effects of reservoir-incompetent hosts on Borrelia burgdorferi sensu stricto transmission

Cited by 8 publications

References 56 publications

Frecuencia de Borrelia burgdorferi sensu lato y Leptospira spp. en pequeños roedores de Yucatán, México

Frecuencia de Borrelia burgdorferi sensu lato y Leptospira spp. en pequeños roedores de Yucatán, México

Infectious Disease Sensitivity to Climate and Other Driver‐Pressure Changes: Research Effort and Gaps for Lyme Disease and Cryptosporidiosis

Modeling of Control Efforts against Rhipicephalus sanguineus, the Vector of Rocky Mountain Spotted Fever in Sonora Mexico

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