Dilemmas in Grading Epidermoid Carcinoma

Sharma, Rachna; Rastogi, Vishal; Puri, N. D.; Mishra, Satyaranjan; Yadav, Lalita; Sabharwal, Robin

doi:10.5005/jp-journals-10001-1171

International Journal of Head and Neck Surgery

2014

DOI: 10.5005/jp-journals-10001-1171

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Dilemmas in Grading Epidermoid Carcinoma

Rachna Sharma¹,

Vishal Rastogi²,

N. D. Puri³

et al.

Abstract: Oral squamous cell carcinoma (OSCC) can be preceded by the appearance of lesions which have the potential either to develop into cancer or signal the development of cancer in the oral cavity. Oral squamous cell carcinoma is the 8th most common cancer worldwide and found particularly in low income communities and mainly a problem of older men, 90% being in the 45-year-age group. Histologic grading has been used as a prognostic factor and for clinical evaluation of OSCC for the past several decades. At the same … Show more

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2020

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Immunohistochemical Expression of BubR1 and Telomerase in Oral Squamous Cell Carcinoma

Garib¹,

Mohammad²,

Hamied³

2020

Sulaimani Dent J

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Objective: Aberrant BubR1 and Telomerase expressions are considered as important markers in tumor progression and clinical outcome. This study purposed to describe, compare, and correlate the immunohistochemical expression of BubR1 and Telomerase in oral squamous cell carcinoma (OSCC). Methods: Immunohistochemical staining was performed for 28 OSCC samples. The samples graded according to Bryne’s grading system. The reaction positivity, intracellular localization, and intensity were recorded. The expression distribution and mean-ranks of these markers were related to OSCC grades by Fisher’s exact and Kruskal Wallis tests. Finally, the correlation between them was achieved by Spearman’s rho test. Results: BubR1 was detected in 89.3% of OSCCs, equally within scores 2 and 3 (35.7%), presented with 50% faint intensity, and 64.3% cytoplasmic localization. Grade III had a significantly higher mean-rank of BubR1 scoring. Whereas Telomerase observed in 75% of OSCCs, mainly found at scores 2 and 3 (60.7%), and 42.9% was within the cytoplasm. Half of OSCCs had faint intensity. No significant differences reported in the mean-rank and stain intensity among the grades. There was no significant correlation between BubR1 and Telomerase expression. Conclusions: OSCCs had high cytoplasmic BubR1 and telomerase expression that cannot ensure proper function. Mean-rank of BubR1 expression related to OSCC grading and being more in high grade. It determines the loss of differentiation and aggressiveness of OSCC. While the mean-rank of Telomerase did not relate to histopathological grading and considered an early event in carcinogenesis, it can use for the diagnostic approach of oral carcinogenesis. These markers have an independent role in cancer progression.

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Immunohistochemical Expression of BubR1 and Telomerase in Oral Squamous Cell Carcinoma

Garib¹,

Mohammad²,

Hamied³

2020

Sulaimani Dent J

View full text Add to dashboard Cite

show abstract

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Dilemmas in Grading Epidermoid Carcinoma

Cited by 1 publication

References 22 publications

Immunohistochemical Expression of BubR1 and Telomerase in Oral Squamous Cell Carcinoma

Immunohistochemical Expression of BubR1 and Telomerase in Oral Squamous Cell Carcinoma

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