Dilation and reduced distensibility of carotid artery in patients with abdominal aortic aneurysms

“…6 Increases in luminal diameter and wall stiffness have been found in the common carotid artery of patients with AAAs compared with healthy controls and patients with atherosclerotic occlusive disease. 7 The incidence of AAAs is increased in patients with coronary artery ectasia, 8,9 cerebral aneurysms, 10 and popliteal aneurysms. 11,12 Saphenous vein bypass grafts in patients with aneurysmal disease are equally likely to have a greater diameter and an increased incidence of development of intrinsic graft aneurysms.…”

mentioning

confidence: 99%

Evidence from cross-sectional imaging indicates abdominal but not thoracic aortic aneurysms are local manifestations of a systemic dilating diathesis

Nordon

Brar

Taylor

et al. 2009

Journal of Vascular Surgery

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A clear understanding of the pathophysiology of aortic aneurysms is essential. Observational studies have raised the suspicion that abdominal aortic aneurysms are a local representation of a systemic disease of the vasculature. Whether aneurysms of the thoracic aorta have a similar systemic tendency is unknown. Validation of this will open broader avenues of research clarifying understanding of the initiating factors of aneurysms and whether all aneurysms distributed through the arterial tree share the same etiology. This may in turn identify systemic treatments that eventually may allow targeted pharmaceutical management of small aortic aneurysms.

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“…However, it is likely that each of these indices has a different role to play in the evaluation of atherosclerosis. 6 Furthermore, gender differences in the relationship between inflammation and atherosclerosis have not been fully clarified. Thus, to identify which atherosclerotic changes are associated with the inflammatory response and to examine whether any association is common to both genders, we investigated the relationship of CRP levels with early carotid atherosclerotic changes and with traditional cardiovascular risk factors in subjects drawn from the general population.…”

mentioning

confidence: 99%

The Association of C-Reactive Protein Levels With Carotid Intima-Media Complex Thickness and Plaque Formation in the General Population

Makita

Nakamura

Hiramori

2005

Stroke

Self Cite

106

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Background and Purpose-An inflammatory response has been associated with the development of atherosclerosis. Our aim was to clarify which atherosclerotic changes (intima-media complex thickness [IMT] increase, plaque formation, and arterial dilatation) are associated with C-reactive protein (CRP) levels and to determine whether there are any gender differences. Methods-Carotid ultrasound and measurement of high-sensitivity CRP (hs-CRP) levels were performed in 2056 subjects selected from a general population (mean age 58.3 years; 1290 men). Results-In both genders, IMT significantly increased with increasing hs-CRP quartile (PϽ0.001), but this relationship disappeared after adjustment for age and other traditional cardiovascular risk factors. In men, but not women, carotid luminal diameter significantly increased with increasing hs-CRP levels (PϽ0.05), but again, this relationship disappeared with adjustment for age and other risk factors. However, in men, but not women, plaque score increased significantly with increasing hs-CRP quartile (PϽ0.01), even after adjustment for age and other traditional risk factors. Conclusions-CRP level was closely associated with early atherosclerotic changes represented by carotid plaque formation. However, the IMT increase was strongly associated with aging and other traditional cardiovascular risk factors rather than CRP level.

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Dilation and reduced distensibility of carotid artery in patients with abdominal aortic aneurysms

Cited by 39 publications

References 34 publications

Site Specificity of Aneurysmal Disease

Site Specificity of Aneurysmal Disease

Evidence from cross-sectional imaging indicates abdominal but not thoracic aortic aneurysms are local manifestations of a systemic dilating diathesis

The Association of C-Reactive Protein Levels With Carotid Intima-Media Complex Thickness and Plaque Formation in the General Population

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