Site Specificity of Aneurysmal Disease

Norman, Paul; Powell, J.T.

doi:10.1161/circulationaha.109.880724

Cited by 131 publications

(117 citation statements)

References 105 publications

(115 reference statements)

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“…However, TAA and AAA have different origins, risk factors, and pathomechanisms. 16 AAAs are related to cardiovascular risk factors, 2 as confirmed in our cohort, with significantly more patients with stroke/TIA, coronary artery disease, hypertension, diabetes, hyperlipidemia, and smoking history in the AAA group than in the TAA group. On the contrary, TAAs and IAs are mostly considered nonatherosclerotic arteriopathies, even though they share some common risk factors with AAAs, such as hypertension or tobacco use.…”

Section: Discussionsupporting

confidence: 69%

“…On the contrary, TAAs and IAs are mostly considered nonatherosclerotic arteriopathies, even though they share some common risk factors with AAAs, such as hypertension or tobacco use. 1,11,14,16,17 TAAs usually appear in younger patients. However, the present study shows that whatever the location of the AA (either TAA or AAA), there is a high prevalence of associated IAs that appears to be independent of cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Intracranial Aneurysms in Patients with Aortic Aneurysms

Rouchaud¹,

Brandt²,

Rydberg³

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Previous studies have suggested an association between aortic aneurysms and intracranial aneurysms with a higher prevalence of intracranial aneurysms in patients with aortic aneurysms. The aims of the present study were to evaluate the incidence of intracranial aneurysms in a large cohort of patients with aortic aneurysms and to identify potential risk factors for intracranial aneurysms in this population.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Prevalence of Intracranial Aneurysms in Patients with Aortic Aneurysms

Rouchaud¹,

Brandt²,

Rydberg³

et al. 2016

AJNR Am J Neuroradiol

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“…In summary, central aortic stiffness by measured by cfPWV or hfPWV is inversely related to aortic size at the level of the sinuses of Valsalva in the most common form of ATAA namely ATAA not due to an inherited aortopathy. 17) The measurement of PWV does not distinguish individuals with ATAA from individuals of the same age with various other cardiovascular conditions without ATAA. These data suggest that the unique features of the sinuses of Valsalva result in an increased aortic compliance that may provide an easy indirect method to evaluate the sinuses of Valsalva in ATAA.…”

Section: Pwv In Ataamentioning

confidence: 99%

“…16) The majority of ATAA cases, however, are not due to Marfan's syndrome, aortopathy of BAV or familial/ genetic factors, but rather are usually ascribed to 'degenerative' factors and comprise 80% of all ATAA cases. 17) There has, however, been little investigation as to whether: changes in aortic stiffness occur in the usual cases of aortic aneurysms that are not due to a specific cause; are evident in smaller aneurysms and are manifest differently depending on the location of the expansion within the ascending thoracic aorta.…”

Section: Introductionmentioning

confidence: 99%

Pulse Wave Velocity Involving Proximal Portions of the Aorta Correlates with the Degree of Aortic Dilatation at the Sinuses of Valsalva in Ascending Thoracic Aortic Aneurysms

Rabkin

Chan

Chow

et al. 2014

Annals of Vascular Diseases

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Objective: To determine the relationship between arterial stiffness measured in different aortic segments and the presence and extent of ascending thoracic aortic aneurysm (ATAA). Methods: Patients at a Thoracic Aortic Diseases clinic at a University teaching hospital were compared to patients attending a Cardiology outpatient Clinic at the same institution. A non-invasive measure of vascular stiffness was performed using pulse wave velocity (PWV) measurement of several vascular segments-carotidfemoral pulse wave velocity (cfPWV), heart-femoral pulse wave velocity (hfPWV) and brachial-ankle pulse wave velocity (baPWV). Aortic dimensions were measured on echocardiogram. Results: Patients with ATAA (N = 32) were 66 years and the same age as those without ATAA (N = 46). There was no significant difference between those with or without aortic aneurysm with respect to cfPWV, hfPWV or baPWV. In ATAA, there was a significant (p <0.05) inverse correlation between aortic diameter at the sinuses of Valsalva and cfPWV, as well as hfPWV, but not with baPWV. This relationship was not evident in persons without ATAA. Conclusion: Reduced aortic stiffness (increased compliance), assessed by cfPWV or hfPWV, correlates with larger aortic size of ATAA at the level of the sinuses of Valsalva but not at the ascending aorta, suggesting cfPWV may be a useful method to assess the size of ATAA at the level of the sinuses of Valsalva. Overall aortic stiffness assessed by PWV did not differentiate persons with or without an ATAA, in individuals who do not have a genetic or inheritable cause of their ATAA.

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“…However, several of these proteins have been associated for the first time with the history of AAA. The formation of degenerative AAAs is associated with inflammation, upregulation of proteolysis, apoptosis, and matrix degradation [19]. To gain insight into early molecular changes leading to AAA development, Nordon et al [20] investigated changes in the vascular tissue proteome, using inferior mesenteric vein (IMV) of patients with AAAs.…”

Section: Proteomics Studies Of Tissue Secretome and Plasma/serum Abdmentioning

confidence: 99%