Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T

Stoll, Victoria; Clarke, William T.; Levelt, Eylem; Liu, Alexander; Myerson, Saul G.; Robson, Matthew D; Neubauer, Stefan; Rodgers, Christopher T.

doi:10.1148/radiol.2016152629

Cited by 32 publications

(33 citation statements)

References 27 publications

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“…Error bars show ±1 SD. The leftmost bar shows DCM patient data acquired by Stoll et al using the same scanning protocol and hardware for comparison…”

Section: Resultsmentioning

confidence: 99%

“…The coefficient of variation (CV), defined as the sample SD divided by the mean, is also reported.

italicCV = italicSD / italicmean .

Datasets X and Y were compared with those collected from 25 patients with dilated cardiomyopathy (DCM) in a previous study using the same 28 min protocol, coils and scanner …”

Section: Methodsmentioning

confidence: 99%

“…Datasets X and Y were compared with those collected from 25 patients with dilated cardiomyopathy (DCM) in a previous study using the same 28 min protocol, coils and scanner. 20…”

Section: Assessment Of Reproducibilitymentioning

confidence: 99%

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Reproducibility of human cardiac phosphorus MRS (³¹P‐MRS) at 7 T

et al. 2019

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Purpose We test the reproducibility of human cardiac phosphorus MRS ( 31 P‐MRS) at ultra‐high field strength (7 T) for the first time. The primary motivation of this work was to assess the reproducibility of a ‘rapid’ 6½ min 31 P three‐dimensional chemical shift imaging (3D‐CSI) sequence, which if sufficiently reproducible would allow the study of stress‐response processes. We compare this with an established 28 min protocol, designed to record high‐quality spectra in a clinically feasible scan time. Finally, we use this opportunity to compare the effect of per‐subject B 0 shimming on data quality and reproducibility in the 6½ min protocol. Methods 10 healthy subjects were scanned on two occasions: one to test the 28 min 3D‐CSI protocol, and one to test the 6½ min protocol. Spectra were fitted using the OXSA MATLAB toolbox. The phosphocreatine to adenosine triphosphate concentration ratio (PCr/ATP) from each scan was analysed for intra‐ and intersubject variability. The impact of different strategies for voxel selection was assessed. Results There were no significant differences between repeated measurements in the same subject. For the 28 min protocol, PCr/ATP in the midseptal voxel across all scans was 1.91 ± 0.36 (mean ± intersubject SD). For the 6½ min protocol, PCr/ATP in the midseptal voxel was 1.76 ± 0.40. The coefficients of reproducibility (CRs) were 0.49 (28 min) and 0.67 (6½ min). Per‐subject B 0 shimming improved the fitted PCr/ATP precision (for 6½ min scans), but had negligible effect on the CR (0.67 versus 0.66). Conclusions Both 7 T protocols show improved reproducibility compared with a previous 3 T study by Tyler et al. Our results will enable informed power calculations and protocol selection for future clinical research studies.

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“…Error bars show ±1 SD. The leftmost bar shows DCM patient data acquired by Stoll et al using the same scanning protocol and hardware for comparison…”

Section: Resultsmentioning

confidence: 99%

“…The coefficient of variation (CV), defined as the sample SD divided by the mean, is also reported.

italicCV = italicSD / italicmean .

Datasets X and Y were compared with those collected from 25 patients with dilated cardiomyopathy (DCM) in a previous study using the same 28 min protocol, coils and scanner …”

Section: Methodsmentioning

confidence: 99%

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Reproducibility of human cardiac phosphorus MRS (³¹P‐MRS) at 7 T

et al. 2019

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“…Using the signal‐to‐noise ratio improvements brought to human cardiac 31 P‐MRS by 7 tesla (T) MR , this work aims to make the first three‐dimensional (3D)–localized measurements of the CK

k_{normalf}^{CK}

in the human myocardium. Three‐dimensional localization will enable measurement of

k_{normalf}^{CK}

from smaller, more sharply delineated voxels and will reduce the dependence of voxel shapes on the receive coil.…”

Section: Introductionmentioning

confidence: 99%

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

Clarke

Robson

Neubauer

et al. 2016

Magnetic Resonance in Med

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PurposeWe present a new Bloch‐Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first‐order effective rate constant kf in human myocardium at 7 tesla (T). BOAST combines a variant of the four‐angle saturation transfer (FAST) method using amplitude‐modulated radiofrequency pulses, phosphorus Bloch‐Siegert normalB1+‐mapping to determine the per‐voxel flip angles, and nonlinear fitting to Bloch simulations for postprocessing.MethodsOptimal flip angles and repetition time parameters were determined from Monte Carlo simulations. BOAST was validated in the calf muscle of two volunteers at 3T and 7T. The myocardial CK forward rate constant was then measured in 10 volunteers at 7T in 82 min (after 1H localization).ResultsBOAST knormalfCK values were 0.281 ± 0.002 s−1 in the calf and 0.35 ± 0.05 s−1 in myocardium. These are consistent with literature values from lower fields. Using a literature values for adenosine triphosphate concentration, we computed CK flux values of 4.55 ± 1.52 mmol kg−1 s−1. The sensitive volume for BOAST depends on the B1 inhomogeneity of the transmit coil.ConclusionBOAST enables measurement of the CK rate constant in the human heart at 7T, with spatial localization in three dimensions to 5.6 mL voxels, using a 10‐cm loop coil. Magn Reson Med 78:20–32, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…In vivo phosphorus ( 31 P) MR spectroscopy (MRS) enables noninvasive studies of energy metabolism, intracellular pH, and phospholipid turnover in living tissue. Mapping 31 P-containing metabolites by means of 31 P MR spectroscopic imaging (MRSI) yielded information concerning, for example, bioenergetics of human muscle (1), heart diseases (2,3), pathologies of the liver (4), pathologic phospholipid metabolism in breast cancer (5,6), and the signature of small metabolites in prostate tumors (7). A notorious problem of 31 P MRSI is the poor spatial resolution owing to the low concentration of 31 P-containing compounds in tissue.…”

Section: Introductionmentioning

confidence: 99%