Diisocyanate mediated polyether modified gelatin drug carrier for controlled release

Abstract

Gelatin is an extensively studied biopolymer hydrogel drug carrier due to its biocompatibility, biodegradability and non-toxicity of its biodegraded products formed in vivo. But with the pristine gelatin it is difficult to achieve a controlled and desirable drug release characteristics due to its structural and thermal lability and high solubility in aqueous biofluids. Hence it is necessary to modify its solubility and structural stability in biofluids to achieve controlled release features with improved drug efficacy and broader carrier applications. In the present explorations an effort is made in this direction by cross linking gelatin to different extents using hitherto not studied isocyanate terminated poly(ether) as a macrocrosslinker prepared from poly(ethylene glycol) and isophorone diisocyanate in dimethyl sulfoxide. The crosslinked samples were analyzed for structure by Fourier transform-infrared spectroscopy, thermal behavior through thermogravimetric analysis and differential scanning calorimetry. The cross linked gelatins were biodegradable, insoluble and swellable in biofluids. They were evaluated as a carrier for in vitro drug delivery taking theophylline as a model drug used in asthma therapy. The crosslinking of gelatin decreased the drug release rate by 10-20% depending upon the extent of crosslinking. The modeled drug release characteristics revealed an anomalous transport mechanism. The release rates for ampicillin sodium, 5-fluorouracil and theophylline drugs in a typical crosslinked gelatin carrier were found to depend on the solubility and hydrophobicity of the drugs, and the pH of the fluid. The observed results indicated that this material can prove its mettle as a viable carrier matrix in drug delivery applications.

Development of a Photo-Crosslinking, Biodegradable GelMA/PEGDA Hydrogel for Guided Bone Regeneration Materials

“…Therefore, the applications of the gelatin hydrogel in vivo are limited, due to its poor mechanical properties, rapid degradation rate, and low transition temperatures. To obtain suitable mechanical strength and stable gelatin hydrogel, various chemical crosslinking methods have been used, such as glutaraldehyde [ 14 , 15 ] and diisocyanate [ 16 , 17 ]. However, most of the chemical crosslinkers are toxic, and their use as cell-laden matrices for tissue engineering application is limited.…”

Synthesis and properties of photopolymerizable bifunctional polyether-modified polysiloxane polyurethane acrylate prepolymer

“…[10][11][12][13][14][15] Hence, it is possible to overcome the poor compatibility and decrease cost of photosensitive polysiloxane prepolymers, and improve the comprehensive performances of the prepolymers by introducing polyether into photosensitive polysiloxane prepolymer molecules.…”

Therapeutic effects of 5‐fluorouracil sustained‐release particles in 81 malignant pericardial effusion patients

“…This result does not indicate that the patients were unsuitable for pericardial pressure after effusion draining, but could be attributed to the first release of 5‐FU or the drug burst release ‐caused reaction. Burst release refers to the transient high‐concentration drug release caused by the residual drugs among the particle microcapsule before the sustained‐release formulation reaches a releasing plateau in the releasing medium or in vivo , which may lead to toxic drug levels in the body [10–12]. Studies have suggested that the preparation should undergo in vitro cleaning before entering the body.…”