Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes

Zhang, Jinping; Zheng, Yongchun; Hong, Bo; Ma, Lei; Zhao, Yingchun; Zhang, Shuai; Sun, Shuwen; Ding, Qiteng; Wang, Yue; Liu, Wencong; Ding, Chuanbo

doi:10.1016/j.biopha.2022.113727

Cited by 7 publications

(4 citation statements)

References 76 publications

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“…One of the roles of the skin, since it covers the entire body, is to provide protection from external threats, such as UV radiation. UV radiation has many deleterious effects on skin cells [26,27]. For example, UV penetrates the skin layer and induces or causes premature skin aging via cell DNA damage, oxidative stress, and cell apoptosis [26,27].…”

Section: Discussionmentioning

confidence: 99%

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Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

et al. 2023

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Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes. We developed a low-cost/high-efficiency method for KRGM gintonin production. We further studied the KRGM gintonin-mediated anti-skin aging effects under UVB exposure using human dermal fibroblasts (HDFs). KRGM gintonin yield is about 8%. KRGM gintonin contains a high amount of LPA C18:2, lysophosphatidylcholine (LPC), and phosphatidylcholine (PC), which is similar to white ginseng gintonin. KRGM gintonin induced [Ca2+]i transient via LPA1/3 receptors and increased cell viability/proliferation under UVB exposure. The underlying mechanisms of these results are associated with the antioxidant action of KRGM gintonin. KRGM gintonin attenuated UVB-induced cell senescence by inhibiting cellular β-galactosidase overexpression and facilitated wound healing. These results indicate that KRGM can be a novel bioresource of KRGM gintonin, which can be industrially utilized as new material for skin nutrition and/or skin healthcare.

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Section: Discussionmentioning

confidence: 99%

“…UV radiation has many deleterious effects on skin cells [26,27]. For example, UV penetrates the skin layer and induces or causes premature skin aging via cell DNA damage, oxidative stress, and cell apoptosis [26,27]. The use of UV protection greatly reduces this deterioration, and so, prevents the appearance of premature aging.…”

Section: Discussionmentioning

confidence: 99%

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

et al. 2023

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“…DHQ is widely distributed in nature, such as larch, Douglas pine, Pinus sylvestris var. mongolica and olive oil all contain more DHQ, especially in the neck of larch root [15]. With the increase of storage time, the content of DHQ in the used plants decreased.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect and Mechanism of DHQ On Ethanol-induced Gastric Mucosal Injury in GES-1 Cells

Hu,

Wang,

et al. 2023

AJST

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It is reported that the incidence of gastric mucosal injury diseases is very high in the world, among which ethanol is one of the most important predisposing factors. In this study, DHQ effectively inhibited ethanol-induced apoptosis of GES-1 cells in a concentration-dependent manner. DHQ can down-regulate the expression of various pro-apoptotic proteins and up-regulate the expression of anti-apoptotic proteins, which may be related to the activation of mitochondrial apoptosis pathway. Therefore, DHQ can protect gastric mucosal epithelial cells to a certain extent, and finally achieve the protective effect of protecting gastric mucosa. Our study provides new insights for the prevention and treatment of gastric mucosal injury diseases, and DHQ can be used as a new therapeutic drug.

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“…The UVB irradiation of the skin can cause an increase in the content of reactive oxygen species (ROS) in skin cells and trigger oxidative stress response [ 6 ]. Oxidative stress can cause many skin problems, such as inflammation and barrier damage [ 7 ]. Impaired skin barrier in atopic dermatitis is strongly associated with the secretion of cytokines (inflammatory factors) by keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects

et al. 2022

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UVB radiation can induce oxidative stress and inflammatory response in human epidermal cells. We establish a UVB-induced damage model of human immortalized epidermal keratinocytes (HaCaT) to explore the protective and reparative effects of Laminaria japonica on UVB-damaged epidermal inflammation after fermentation by white Ganoderma lucidum (Curtis) P. Karst and Saccharomyces cerevisiae. Compared with unfermented Laminaria japonica, fermented Laminaria japonica possesses stronger in vitro free radical scavenging ability. Laminaria japonica white Ganoderma lucidum fermentation broth (LJ-G) and Laminaria japonica rice wine yeast fermentation broth (LJ-Y) can more effectively remove excess reactive oxygen species (ROS) in cells and increase the content of the intracellular antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO-1). In addition, fermented Laminaria japonica effectively reduces the content of pro-inflammatory factors ILs, TNF-α and MMP-9 secreted by cells. The molecular research results show that fermented Laminaria japonica activates the Nrf2 signaling pathway, increases the synthesis of antioxidant enzymes, inhibits the gene expression levels of pro-inflammatory factors, and alleviates cellular oxidative stress and inflammatory response caused by UVB radiation. Based on the above results, we conclude that fermented Laminaria japonica has stronger antioxidant and anti-inflammatory activity than unfermented Laminaria japonica, possesses good safety, and can be developed and used as a functional inflammation reliever. Fermented Laminaria japonica polysaccharide has a more slender morphological structure and more rockulose, with better moisturizing and rheological properties.

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Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes

Cited by 7 publications

References 76 publications

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

Protective Effect and Mechanism of DHQ On Ethanol-induced Gastric Mucosal Injury in GES-1 Cells

Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects

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