Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis

Teselkin, Yu. O.; Babenkova, I. V.; Kolhir, V. K.; Baginskaya, A. I.; Tjukavkina, N. A.; Kolesnik, Yu. A.; Селиванова, И. А.; Eichholz, Andrew

doi:10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y

Cited by 72 publications

(39 citation statements)

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“…A number of investigators have previously demonstrated that anti-oxidants prevent CCl 4 toxicity, particularly hepatotoxicity, by inhibiting lipid peroxidation (Teselkin et al, 2000), suppressing sGOT and sGPT activities (Datta et al, 1998;Lin et al, 2000a,b), and increasing the activities of anti-oxidant enzymes (Kumaravelu et al, 1995). Silymarin is a group of flavones extracted from Silubum marianum L. and is a strong anti-oxidant (Hjelle and Klaassen, 1984).…”

Section: Introductionmentioning

confidence: 90%

Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1

Peng

Tien

Huang

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 90%

Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1

Peng

Tien

Huang

et al. 2010

Journal of Ethnopharmacology

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“…Although data are limited, it has been suggested that the hepatoprotective effects have an antioxidant mechanistic basis, and that CCl4 toxicity, particular hepatotoxicity, is due to the inhibition of lipid peroxidation (Teselkin et al, 2000), the suppression of SGOT and SGPT (Lin and Huang, 2000), and the augmentation of antioxidant enzymes (Kumaravelu et al, 1995). Several researches have reported that probiotics and their fermented products possess antioxidative activities and free radical scavenging properties in vitro and in vivo (Osman et al, 2007;Nurrochmad et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

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Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

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“…(1) Inactivation of cytotoxic substances [3]; (2) Antidiabetic activity [4]; (3) Termination of free radicals and peroxidation prevention [5,6]; (4) Reduction of lipoprotein content in liver and blood plasma [7]; (5) Antitumour effect [8]; (6) Antimutagene activity ]9]; (7) Antiradiation activity [10]; (8) Immunoregulatory (antiallergic) and anti-inflammatory activity [11,12].…”

Section: Fig 1 Taxifolin (Dihydroquercetin) (Atoms Numeration)mentioning

confidence: 99%

Synthesis and Properties of New Dihydroquercetin Derivatives

Koroteev¹,

Kukhareva²,

Koroteev³

et al. 2015

JPP

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Abstract:This paper is to analyze the latest data on synthesis, structure, chemical and biological properties of flavonoid dihydroquercetin (taxifolin). Complexes including DHQ (dihydroquercetin) into cyclodextrins were obtained. These supramolecular representatives are characterized by high water-solubility, good permeability through biomembranes, prolonged action in the organism and stability while being transported in bloodflow. The use of DHQ in complex with β-cyclodextrin is more promising from the medical point of view than the use of pure DHQ. Total and partial acidylation of DHQ with acid chlorides of aliphatic, aromatic, and heterocyclic carboxylic acids, as well as selective phosphorylation with acid derivatives of trivalent phosphorus (with amides and amidethers of phosphorous acid), and aminomethylation were carried out. DHQ freely undergoes Mannich Reaction with formaldehyde and amines of various structures. The products of the reaction are isolated from the reaction mix with good yield. Isolated aminomethylated derivatives have neurotropic and antiproliferative action.The structure of all synthesized compounds was proved with the help of modern methods of analysis: spectroscopy NMR ( 1 H, 13 C) and XRS. Biological activity of dihydroquercetin modified derivatives was studied. It was found out that some of them are characterized by high cytotoxic, antitumour, and antioxidant biological activity. The inclusion complexes of dihydroquercetin and cyclodextrin were obtained. Acylation, phosphorylation and aminomethylation of dihydroquercetin was performed. The biological activity of obtained compounds was studied.

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Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis

Cited by 72 publications

References 1 publication

Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1

Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Synthesis and Properties of New Dihydroquercetin Derivatives

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