Dihydromyricetin inhibited ovalbumin-induced mice allergic responses by suppressing the activation of mast cells

Zhang, Yafen; Liu, Qingmei; Liu, Bo; Shu, Zhendan; Han, Jing; Liu, Hong; Cao, Min‐Jie; Yang, Xian‐Wen; Gu, Wei

doi:10.1039/c9fo01557d

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…Not only resveratrol but also several other natural plant substances have been shown to have an anti-inflammatory effect on MC. In in vivo OVA models these were, amongst others, Chinese sweet tea (1% weight/volume (w/v)) [61], the flavonoid dihydromyricetin (10 mg/kg) [83], polyphenols from Arecae semen (0.1% w/v) [60] or the polyphenol fisetin (3 mg/kg/day) [84]. Degranulation of MC in jejuni (ca.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Bilotta

Arbogast

Schart

et al. 2022

IJMS

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Mast cells are involved in allergic and other inflammatory diseases. The polyphenol resveratrol is known for its anti-inflammatory properties and may be used as nutraceutical in mast cell associated diseases. We analyzed the effect of resveratrol on mast cells in vivo in ovalbumin-induced allergic enteritis as well as experimental colitis in IL-10−/− mice which received resveratrol via drinking water. Treatment with resveratrol prevented the increase in mast cells in both allergic enteritis and chronic colitis in duodenum as well as in colon. Further, it delayed the onset of diseases symptoms and ameliorated diseases associated parameters such as tissue damage as well as inflammatory cell infiltration in affected colon sections. In addition to the findings in vivo, resveratrol inhibited IgE-dependent degranulation and expression of pro-inflammatory cytokines such as TNF-α in IgE/DNP-activated as well as in LPS-activated bone marrow-derived mast cells. These results indicate that resveratrol may be considered as an anti-allergic and anti-inflammatory plant-derived component for the prevention or treatment of mast cell-associated disorders of the gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Bilotta

Arbogast

Schart

et al. 2022

IJMS

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“…Thus, the anti-allergic activities of natural sources have attracted our attention due to their low side effects. As reported, terpenoids, flavenoids, and alkaloids have significant anti-allergic activities and different mechanisms of action [ 29 , 45 , 46 ]. Alkaloids are nitrogen-containing compounds that have many biological activities, including antiviral, anti-inflammation, and anti-allergy properties.…”

Section: Discussionmentioning

confidence: 99%

“…The bioactivity of these compounds is closely related to their structures. For example, the number and position of hydroxyl groups have been shown to be associated with anti-allergic activities [ 45 ]. Moreover, both in antigen-induced and A23187-induced RBL-2H3 cell degranulation models, the inhibitory effect of viridicatol on β-hexosaminidase were stronger than viridicatin, which may due to the presence of an extra phenolic hydroxyl.…”

Section: Discussionmentioning

confidence: 99%

“…It has previously been reported that the level of β-hexosaminidase and histamine from RBL-2H3 cells activated by IgE–FcεRI complex were detected [ 45 ]. The cellular cytotoxicity of viridicatol was measured using MTT (3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide) assay.…”

Section: Methodsmentioning

confidence: 99%

“…As previously reported, single-cell suspensions were obtained on day 41 by density gradient centrifugation from the mouse spleen tissue suspension [ 45 ]. The cells were labeled with anti-CD3, anti-CD4, anti-CD19, anti-Foxp3, anti-FcεRI, and anti-c-KIT on the surface.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation

et al. 2020

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Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were established to explore the anti-allergic properties of viridicatol. On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-α; and promote the production of interleukin-10 in the serum. The treatment of viridicatol also downregulated the population of B cells and mast cells (MCs), as well as upregulated the population of regulatory T cells in the spleen. Moreover, viridicatol alleviated intestinal villi injury and inhibited the degranulation of intestinal MCs to promote intestinal barrier repair in mice. Furthermore, the accumulation of Ca2+ in RBL-2H3 cells was significantly suppressed by viridicatol, which could block the activation of MCs. Taken together, these data indicated that deep-sea viridicatol may represent a novel therapeutic for allergic diseases.

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Effects of Lactobacillus fermentation on Eucheuma spinosum polysaccharides: Characterization and mast cell membrane stabilizing activity

Zhang

Liu

et al. 2023

Carbohydrate Polymers

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Dihydromyricetin inhibited ovalbumin-induced mice allergic responses by suppressing the activation of mast cells

Abstract: Dihydromyricetin (DMY) is a natural flavonoid compound derived from Lysionotus pauciflorus Maxim and has been found to possess therapeutic potential for allergic disease induced by food allergens.

Cited by 15 publications

References 47 publications

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation

Effects of Lactobacillus fermentation on Eucheuma spinosum polysaccharides: Characterization and mast cell membrane stabilizing activity

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