Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

Ren, Zhaoxiang; Yan, Pengju; Zhu, Liu-shuai; Yang, Hui‐Jun; Zhao, Yizheng; Kirby, Brian P.; Waddington, John L.; Zhen, Xuechu

doi:10.1007/s00213-017-4761-z

Cited by 55 publications

(36 citation statements)

References 58 publications

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“…These findings may be related to the antidepressant effect seen on TST and FST after once-daily administration of 10 and 20 mg/kg, v.o. for 3 days, but not after a single acute dose [41]. Interestingly, dihydromyricetin reverted the depressogenic effect caused by CUMS in mice subjected to SPT and FST, or TST, only after administration of once daily for 7 days, but not 3 days [41].…”

Section: Flavonoids With Antidepressant Effects: Preclinical Researchmentioning

confidence: 91%

“…for 3 days, but not after a single acute dose [41]. Interestingly, dihydromyricetin reverted the depressogenic effect caused by CUMS in mice subjected to SPT and FST, or TST, only after administration of once daily for 7 days, but not 3 days [41]. Another flavonoid analyzed is hesperidin, which increased BDNF levels in the hippocampus after administration of once daily for 21 days (0.3 and 1 mg/kg, i.p.).…”

Section: Flavonoids With Antidepressant Effects: Preclinical Researchmentioning

confidence: 99%

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Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

García-Ríos¹,

Mora-Pérez²,

Ramos-Molina³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Depression and anxiety currently rank as the second and fifth most common causes worldwide of years lived with disability-a reality that has intensified the search for new treatments. There are many studies of herbal extracts and secondary metabolites from plants used in traditional medicine due to their antidepressant and anxiolytic properties. Clinical and preclinical studies about some of the mechanisms of action of metabolites like alkaloids, terpenes, flavonoids, and sterols, among others, have documented effects similar to those produced by clinically effective drugs. These metabolites have shown anxiolytic and antidepressant effects in various experimental models of anxiety by interacting with γ-aminobutyric acid subtype A receptors (GABA A-receptors) and by stimulating the serotonergic, noradrenergic, and dopaminergic neurotransmitter systems. These pharmacological effects can be attributed to plant metabolites that share structural similarities with monoamines, which allow them to bind to receptors. The objective of this chapter is to summarize the various mechanisms of action that have been identified in secondary metabolites with anxiolytic and antidepressant properties. Terpenes, alkaloids, flavonoids, and sterols can interact at different levels of the neurotransmission systems involved in the neurobiology of anxiety and depression, suggesting their potential for treating these mental illnesses.

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Section: Flavonoids With Antidepressant Effects: Preclinical Researchmentioning

confidence: 91%

Section: Flavonoids With Antidepressant Effects: Preclinical Researchmentioning

confidence: 99%

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

García-Ríos¹,

Mora-Pérez²,

Ramos-Molina³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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show abstract

“…DHM is a natural compound that is used to overcome alcohol hangover [9]. It also has antidiabetic [21], anti-Parkinson [22], anti-Alzheimer [11], antidepressant [23], and anti-inflammatory effects with cognitive enhancing properties [24]. Previous studies show that DHM acts as a GABAA receptor ligand.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice

et al. 2020

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Objective Dihydromyricetin (DHM), a natural flavonoid, is used to reduce alcohol hangover. It has a modulatory role on GABAA receptors with significant effects on seizure and anxiety in animal models. We aimed to evaluate the effect of DHM on morphine conditioned place preference (CPP) and withdrawal sings following morphine dependence using animal models. Methods The effect of DHM (1, 2 and 5 mg/kg, intraperitoneal; ip) on the acquisition and expression of morphine-induced CPP was evaluated in male mice. Administration of morphine for three consecutive days induced physical dependence. The withdrawal signs such as jumping and defecation were precipitated by administration of naloxone (8 mg/kg, ip). The effect of DHM on the development of physical dependence was assessed by injection of DHM before morphine administrations. Results DHM, at the dose of 5 mg/kg, reduced expression of morphine CPP with an increase in the locomotor activity. DHM, at the doses of 2 and 5 mg/kg, also reduced development of morphine CPP. DHM alleviated development of morphine-induced physical dependence at the dose of 1, 2, and 5 mg/kg by decreasing jumping and defecation. Conclusion These results indicated that DHM decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence.

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“…DMY treatment for 7 days increased in sucrose preference but decreased FST and TST time in chronic unpredictable mild stress (CUMS) model. The attenuation effects on CUMS-induced depression-related and anxiety-related behaviors were attributed to the elevated BDNF pathway ( Ren et al, 2018 ). These findings provide the solid evidence that DMY may be a promising candidate for the treatment of MDD.…”

Section: Neuroprotectionmentioning

confidence: 99%

Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

et al. 2018

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As the most abundant natural flavonoid in rattan tea, dihydromyricetin (DMY) has shown a wide range of pharmacological effects. In addition to the general characteristics of flavonoids, DMY has the effects of cardioprotection, anti-diabetes, hepatoprotection, neuroprotection, anti-tumor, and dermatoprotection. DMY was also applied for the treatment of bacterial infection, osteoporosis, asthma, kidney injury, nephrotoxicity and so on. These effects to some extent enrich the understanding about the role of DMY in disease prevention and therapy. However, to date, we still have no outlined knowledge about the detailed mechanism of DMY, which might be related to anti-oxidation and anti-inflammation. And the detailed mechanisms may be associated with several different molecules involved in cellular apoptosis, oxidative stress, and inflammation, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), protein kinase B (Akt), nuclear factor-κB (NF-κB), nuclear factor E2-related factor 2 (Nrf2), ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-γ (PPARγ) and so on. Here, we summarized the current pharmacological developments of DMY as well as possible mechanisms, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.

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Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

Abstract: The present data indicate that DHM exerts a more rapid antidepressant-like effect than does a typical antidepressant, in association with enhancement of BDNF expression and inhibition of neuroinflammation.

Cited by 55 publications

References 58 publications

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

Neuropharmacology of Secondary Metabolites from Plants with Anxiolytic and Antidepressant Properties

The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice

Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

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