Digital Signal Processing for Molecular Communication via Chemical-Reaction-Based Microfluidic Circuits

Chemical Reactions-Based Microfluidic Transmitter and Receiver Design for Molecular Communication

“…Although the aforementioned genetic circuits has advantages in biocompatibility and miniaturization over electrical circuits, the experimental realization of genetic circuits for signal processing faces challenges, such as slow speed, unreliability, and non-scalability [25]. This motivates our initial work on chemical reactions-based microfluidic circuits [26]- [28]. Unlike genetic circuits, chemical circuits are much easier to be controlled, and their integration with microfluidic devices brings advantages in low reagents consumption, rapid analysis, and high efficiency [29].…”

“…In [26], [27], we designed an MC microfluidic transceiver based on chemical reactions to successfully realize the binary concentration shift keying (BCSK) modulation and demodulation functions. The signal processing capability of chemical reactions-based microfluidic circuits is further exploited in [28], where we provided the designs of the AND gate, NAND gate, NOR gate, OR gate, and XOR gate, which are validated through COMSOL simulations. Echoing the discussion in [28], one challenge in realizing signal processing functions via chemical reactions-based microfluidic circuits design is the theoretical characterization of the logic gate, which facilitates the design parameters selection for the expected gate outputs.…”

“…The signal processing capability of chemical reactions-based microfluidic circuits is further exploited in [28], where we provided the designs of the AND gate, NAND gate, NOR gate, OR gate, and XOR gate, which are validated through COMSOL simulations. Echoing the discussion in [28], one challenge in realizing signal processing functions via chemical reactions-based microfluidic circuits design is the theoretical characterization of the logic gate, which facilitates the design parameters selection for the expected gate outputs. Although we mathematically modelled the dynamics of molecular species in microfluidic channels in [26], [27], this analysis is not scalable with the increase in the number of microfluidic circuits.…”

A Survey of Molecular Communication in Cell Biology: Establishing a New Hierarchy for Interdisciplinary Applications

“…The authors of [230] also used the bistable mechanism, where five general and circuit-free methods were proposed to synthesize arbitrary combinational logic gates. The AND, OR, NOR, and XOR gates were also realized via joint chemical reactions and microfluidic design in [231] with a different bit interpretation, where bit-1 is represented by a non-zero concentration value and bit-0 is represented by zero concentration. A mathematical framework was proposed in [232] to theoretically characterize the designed gates, and insights were also provided into design parameter selection (e.g., species concentrations) to ensure an exhibition of desirable behavior.…”

Construction of Automatic Acquisition System for Multichannel Electronic Communication Signals Based on Sorting Optimization Algorithm

“…ere are some researches on the automatic capture system of multichannel electronic communication signals by scholars: Zhang et al [1] dealt with the existing electronic communication signal capture problem in a datadriven manner by mining the intrinsic characteristics of real data [1]; Li [2] focused on the research on the in uence of atmospheric environment in coastal areas and the optimization of communication signal processing, and created a Lagrangian smog di usion model based on pollution levels, meteorological conditions, and initial parameters of the subsurface near the surface [2]; Raza et al [3] created a lowcommunication parallel distributed adaptive signal processing architecture for processing ine cient platforms [3]. To facilitate micro uidic circuit design, Bi and Deng [4] identi ed primary and secondary components, showing how to build tertiary basic modules and discussed the solution of four-level digital logic gate in designing, constructing, and testing micro uidic circuits with complex signal processing function [4]. Heath [5] separated electrical signals for multiple receivers in fiber optic communication systems into multiple groups.…”