Digital ischemia in Behçet’s disease: case-based review

Hari, Gopika; Skeik, Nedaa

doi:10.1007/s00296-019-04452-z

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Therefore, effective management of BD and its cardiovascular complications necessitates multidisciplinary collaboration among specialists, including physicians, cardiologists, cardiovascular surgeons, and endovascular interventionists. Digital ischemia in the lower extremities, attributed to small-vessel involvement, is an exceedingly rare presentation in VBD [20]. A comprehensive literature review yielded only a limited number of cases documenting isolated small-vessel-related limb ischemia in BD patients.…”

Section: Discussionmentioning

confidence: 99%

“…A comprehensive literature review yielded only a limited number of cases documenting isolated small-vessel-related limb ischemia in BD patients. Effective BD management requires a multidisciplinary approach wherein patients with vascular involvement primarily receive immunosuppressive agents supplemented by antithrombotic therapy following thromboembolic events [20]. Medical treatment optimization during the initial inflammatory phase is crucial before surgical interventions [3,17].…”

Section: Discussionmentioning

confidence: 99%

“…Medical treatment optimization during the initial inflammatory phase is crucial before surgical interventions [3,17]. More severe cases may necessitate systemic anti-inflammatory therapy, including systemic corticosteroids, azathioprine, colchicine, thalidomide, or tumor necrosis factor-alpha inhibitors [20][21][22][23]. Notably, colchicine is employed for recurrent erythema nodosum, genital ulcers, and acute arthritis.…”

Section: Discussionmentioning

confidence: 99%

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Blue Toe Syndrome in Behçet’s Disease: A Case Report

Aljarrah,

Ba-shammakh,

Allouh

et al. 2024

Am J Case Rep

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Unusual clinical course Background:Vascular Behçet's disease (VBD) is a rare but potentially life-threatening subtype of Behçet's disease that is characterized by multisystemic vasculitis. It primarily affects males with ancestry traced back to regions along the ancient Silk Road. Both arteries and veins, regardless of size, may exhibit complications, including aneurysmal degeneration or occlusion. While venous involvement is observed in two-thirds of VBD cases, arterial complications are notably the most severe and lethal. Arterial aneurysmal degeneration is more common than occlusive complications, with larger arteries being predominantly affected in VBD. Data regarding isolated small-vessel arterial occlusive disease in VBD are limited. Given the rarity of this presentation in this patient population, it becomes mandatory to thoroughly evaluate such patients to differentiate small-vessel vasculitis from other similar diseases, such as Raynaud's phenomenon, which has a different etiology and management and generally has a more benign course. Here, we delineate the concept of isolated small-vessel vasculitis as a cause of blue toe syndrome in patients with VBD. Case Report:This report describes a distinctive case of vascular Behçet's disease in a 51-year-old man who initially exhibited unilateral blue toe syndrome, which swiftly progressed to dry gangrene of the toes. Despite reports of large-vessel involvement, there is a paucity of data on isolated small-vessel vasculitis-induced digital ischemia in VBD. Conclusions:This atypical case underscores the necessity of clinical discernment in differentiating inflammatory microvascular occlusive disease from vasospastic Raynaud's syndrome, both of which can complicate Behçet's disease.

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Section: Discussionmentioning

confidence: 99%