Digital gangrene and Raynaud's phenomenon as complications of lung adenocarcinoma

Kopterides, Petros; Tsavaris, Nikolas; Tzioufas, Athanasios G.; Pikazis, Dimitrios; Lazaris, Andreas

doi:10.1016/s1470-2045(04)01566-9

Cited by 21 publications

(10 citation statements)

References 5 publications

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“…La première description de nécrose digitales paranéoplasique a été faite par O'Connor en 1884 [1]. Depuis, on ne dénombre qu'une cinquantaine de case reports, majoritairement associés à des tumeurs solides, et principalement à des carcinomes [2], notamment ovariens [3], pulmonaires [4], rénaux [5], gastro-intestinaux [6], ORL [7]. .…”

Section: Discussionunclassified

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Une cause rare de nécroses digitales : la maladie de Hodgkin

et al. 2011

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Section: Discussionunclassified

“…. ), mais est également lié au cancer lui-même [4]. L'inflammation liée à la tumeur amplifie aussi la coopération entre les cellules du compartiment vasculaire (lymphocytes, monocytes-macrophages, cellules tumorales, cellules endothéliales et plaquettes).…”

Section: Discussionunclassified

Une cause rare de nécroses digitales : la maladie de Hodgkin

et al. 2011

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“…Do sada je u literaturi opisano 33 slučaja maligne bolesti povezane s digitalnom ishemijom prstiju 8 . Opisan je uz neoplazme tankog crijeva, karcinom pluća, želuca, gušterače, maternice, jajnika, bubrega i limfoproliferativne bolesti [9][10][11][12][13] . Javlja se i uz karcinome dojke 14 .…”

Section: Uvodunclassified

Raynaud’s phenomenom as a first manifestation of high grade serosus carcinoma

Turina

Eminović

Ferari

et al. 2019

Med. Flum. (Online)

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Sažetak. Cilj: Prikazati slučaj pacijentice s Raynaudovim fenomenom kao prvom manifestacijom seroznog karcinoma visokog gradusa te dijagnostički i terapijski postupak. Prikaz slučaja: Pacijentica stara 47 godina upućena je na Odjel za reumatologiju i kliničku imunologiju zbog pozitivnih antinuklearnih antitijela i Raynaudova fenomena. Kliničkim pregledom i laboratorijskom obradom isključena je sistemska bolest vezivnog tkiva. Ultrazvukom abdomena uočena je cistična tvorba u području zdjelice. Tumorski markeri CA-125, HE-4 bili su povišeni. PET/CT analizom (pozitronska emisijska tomografija / kompjutorizirana tomografija) uočeno je pojačano nakupljanje radiofarmaka u supra/ retroklavikularnim limfnim čvorovima, zdjelično i paraaortalno. Citološka punkcija limfnog čvora na vratu upućivala je na metastatski slabodiferencirani adenokarcinom. Učinjena je laparoskopija desnog i lijevog jajnika, obostrana salpingektomija te zdjelična limfadenektomija. Patohistološka analiza potvrdila je da se radi o intraepitelnom seroznom karcinomu visokog gradusa jajovoda. Nakon dijagnostičke obrade provedeno je 6 ciklusa kemoterapije (Paklitaksel i Carboplatina). Na kontrolnom CT-u nije bilo znakova diseminacije osnovne bolesti. Pacijentica je trenutno dobrog općeg stanja i liječi se Olaparibom. Raynaudov fenomen je u značajnom poboljšanju. Zaključak: Serozni karcinom visokog gradusa može se prezentirati na atipičan način. Iznenadna pojava Raynaudova fenomena kod mlađih osoba treba pobuditi sumnju na moguću malignu bolest. Ključne riječi: karcinom jajnika; karcinom jajovoda; Raynaudov fenomen; serozni karcinom visokog gradusa Abstract. Aim: To present a case of a patient with Raynaud's phenomenom as the first manifestation of a high grade serosus carcinoma. Case report: A 47-year-old female has been referred to the Department of Rheumatology and Clinical Immunology due to the positive antinuclear antibodies and Raynaud's phenomena. Both clinical examination and laboratory treatment excluded systemic connective tissue disease. Abdominal ultrasound revealed cystic formation in the pelvis area. Tumor markers CA-125, HE-4 were elevated. PET / CT analysis (positron emission tomography/computed tomography) observed increased radiotracer uptake involving supra/retroclavicular lymph nodes, pelvic and paraortal. The cytology of the lymph node at the neck indicated a metastatic weak-bound adenocarcinoma. Left and right ovarian laparoscopy, double salpingectomy and pelvic lymphadenectomy were performed. The pathological analysis confirmed that it was intraepithelial serous high grade

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“…The term "paraneoplastic syndrome" has been used to describe a clinical manifestation associated with a malignant neoplasm, which is not a direct consequence of invasive tumor growth. Digital ischemia with gangrene has been observed as a paraneoplastic manifestation associated with various malignant tumors, especially adenocarcinomas (1)(2)(3)(4)…”

Section: Examination Revealed Normal Pulses In Femoral and Popliteal mentioning

confidence: 99%

"Digital Ischemia as a Paraneoplastic Manifestation of Lung Cancer" Clinical Image

et al. 2010

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P i c t u r e 1 . Di f f u s e n e c r o t i c l e s i o n s i n b e l o w k n e e l i mb s a n d g a n g r e n e i n b o t h f o o t s . P i c t u r e 2 . No t e t h a t t h e l e s i o n s d o n o t h a v e t h e t y p i c a l l o c a l i z e d a n a t o mi c a l t o p o g r a p h y t h a t a c c o mp a n i e s t h e p e r i p h e r a l a t h e r o s c l e r o t i c d i s e a s e ( P AD) . PICTURES IN CLINICAL

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Digital gangrene and Raynaud's phenomenon as complications of lung adenocarcinoma

Cited by 21 publications

References 5 publications

Une cause rare de nécroses digitales : la maladie de Hodgkin

Une cause rare de nécroses digitales : la maladie de Hodgkin

Raynaud’s phenomenom as a first manifestation of high grade serosus carcinoma

"Digital Ischemia as a Paraneoplastic Manifestation of Lung Cancer" Clinical Image

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