"Digital Ischemia as a Paraneoplastic Manifestation of Lung Cancer" Clinical Image

Abstract

P i c t u r e 1 . Di f f u s e n e c r o t i c l e s i o n s i n b e l o w k n e e l i mb s a n d g a n g r e n e i n b o t h f o o t s . P i c t u r e 2 . No t e t h a t t h e l e s i o n s d o n o t h a v e t h e t y p i c a l l o c a l i z e d a n a t o mi c a l t o p o g r a p h y t h a t a c c o mp a n i e s t h e p e r i p h e r a l a t h e r o s c l e r o t i c d i s e a s e ( P AD) . PICTURES IN CLINICAL

Examining the differential of digital ischaemia and review of paraneoplastic ischaemia

“…Resolution was seen following lobectomy and the removal of the tumour with the writers postulating that the presentation of the patient may represent a paraneoplastic manifestation of malignancy 2. Since then, a small group of case reports and case series have described similar presentations associated with primary lung malignancy with the histopathology most commonly identified as adenocarcinoma 1–6 10–16…”

Acrocyanosis, Digital Ischemia and Acronecrosis as first manifestations of Endometrial Adenocarcinoma: Case Presentation and Literature Review

“…They also suggest that when digital necrosis occurs, physicians should be alerted to consider a possible occult malignancy, especially in the presence of age >50 years and thrombocytosis [24] In many of the reported cases in the literature, as well as in our case, the prognosis is extremely poor. In fact, patients have almost always primary tumor in advanced stage, they present poor clinical conditions and survive only few months after digital necrosis onset [4][5][6][7][8][9].…”

“…Since then, few other cases have been described in literature, in association with different types of primary tumor [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (Table 1). In the most cases the patients were elderly women with adenocarcinomas of digestive or gynaecologic apparatuses [10,11].…”

Digital Ischemia in Patients with Solid Tumors: a Case Report and Review of the Literature

“…Digital ischemia is a rare, paraneoplastic phenomenon associated with various malignant tumours, especially adenocarcinomas which cause has not been completely clarified [1].…”