Digital Assessment of Endothelial Function and Ischemic Heart Disease in Women

Matsuzawa, Yasushi; Sugiyama, Seigo; Sugamura, Koichi; Nozaki, Toshimitsu; Ohba, Keisuke; Konishi, Masaaki; Matsubara, Junichi; Sumida, Hitoshi; Kaikita, Koichi; Kojima, Sunao; Nagayoshi, Yasuhiro; Yamamuro, Megumi; Izumiya, Yasuhiro; Iwashita, Satomi; Matsui, Kunihiko; Jinnouchi, Hideaki; Kimura, Kazuo; Umemura, Satoshi; Ogawa, Hisao

doi:10.1016/j.jacc.2009.10.073

Cited by 206 publications

(209 citation statements)

References 32 publications

(36 reference statements)

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…This method has been validated and described previously in other populations16, 17, 18, 19, 20 and in patients with AF 21. After a 5‐minute baseline measurement, the blood pressure cuff on the test arm was inflated to 60 mm Hg above baseline systolic blood pressure or a maximum of 200 mm Hg for 5 minutes.…”

Section: Methodsmentioning

confidence: 99%

Age‐Dependent Predictive Value of Endothelial Dysfunction for Arrhythmia Recurrence Following Pulmonary Vein Isolation

Matsuzawa

Suleiman

Guddeti

et al. 2016

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundThe mechanisms of atrial fibrillation (AF) are highly divergent. The prevalence of AF increases significantly with age, and underling mechanisms might vary with age. Endothelial dysfunction may be associated with AF and atrial arrhythmia recurrence after catheter ablation. We tested the hypothesis that the impact of endothelial dysfunction on arrhythmia recurrence following catheter ablation is age dependent.Methods and ResultsThis study enrolled 92 participants with AF undergoing catheter ablation. Endothelial function was assessed by peripheral arterial tonometry before ablation, and the natural logarithmic transformation of reactive hyperemia index was calculated. Endothelial dysfunction was defined as a natural logarithmic transformation of reactive hyperemia index <0.618 (median). Participants were followed for atrial tachycardia, flutter, and fibrillation recurrence for a median of 14 months. The mean age was 57±10 years. There was significant interaction between age and endothelial dysfunction in association with recurrence of AF (P=0.029) and any atrial arrhythmia (P=0.015), and the risk associated with endothelial dysfunction for arrhythmia recurrence was higher in younger versus older participants. Participants were divided into 2 age groups at a threshold of 60 years. Among participants aged ≤60 years, multivariate Cox proportional hazards analysis revealed the independent association between endothelial dysfunction and increased risk of arrhythmia recurrence (hazard ratio for AF 4.18 [95% CI 1.33–15.82], P=0.014, and for any atrial arrhythmia 3.62 [95% CI 1.29–11.81], P=0.014). Kaplan–Meier analysis showed that participants with endothelial dysfunction had significantly higher rates of recurrence of AF (P=0.01) and any atrial arrhythmia (P=0.002).ConclusionsThe risk associated with endothelial dysfunction for arrhythmia recurrence following catheter ablation was age dependent and was higher in younger participants.

show abstract

Section: Methodsmentioning

confidence: 99%

Age‐Dependent Predictive Value of Endothelial Dysfunction for Arrhythmia Recurrence Following Pulmonary Vein Isolation

Matsuzawa

Suleiman

Guddeti

et al. 2016

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, finger plethysmography peripheral arterial tonometry has also been used. 42,43 Circulating levels of nitrite/nitrate, cyclic guanosine 3 0 ,5 0 -monophosphate, vascular cell adhesion molecule-1, intracellular adhesion molecule-1, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, von Willebrand factor, asymmetrical dimethylarginine, endothelial microparticles and progenitor cells are also measured as indices of endothelial function. 21,[44][45][46][47] However, these measurements do not directly reflect the production of NO from endothelial cells and are not 'function' .…”

Section: Endothelial Functionmentioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

View full text Add to dashboard Cite

Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

show abstract

“…Matsuzawa, et al reported that RH-PAT index predicts the presence of Ischemic Heart Disease (IHD), especially non-obstructive coronary artery disease [24]. Vascular endothelial dysfunction was found in half of women with chest pain, in the absence of overt blockages in large coronary arteries, termed as coronary microvascular dysfunction.…”

Section: Vascular Endothelial Function and Coronary Artery Diseasementioning

confidence: 99%

“…RH-PAT has been tested in several clinical trials at multiple centers [18, 21,22]. The results from clinical trials have shown that RH-PAT could be useful for risk evaluation, stratification and prognosis of getting major cardiovascular events [18,20,[23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%