Digestive absorption of silicon, supplemented as orthosilicic acid–vanillin complex

Marcowycz, Aline; Housez, Béatrice; Maudet, Corinne; Cazaubiel, Murielle; Rinaldi, Guiseppe; Croizet, Karine

doi:10.1002/mnfr.201400881

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…Silicon is a microelement whose role and essentiality for the human organism remains unclear [25]. However, in view of the available research data its connection with the functioning of connective tissues seems to be unquestionable [26,27]. An association has been found between dietary silicon and bone condition in humans [28].…”

Section: Introductionmentioning

confidence: 99%

Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis – analysis in consideration of gender

Musik

Kurzepa

Luchowska-Kocot

et al. 2019

Ann Agric Environ Med.

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Introduction and objective. Osteoarthrits (OA) is a complex, chronic disorder of cartilage and bone, related to homeostasis of bioelements. The current study aimed at evaluation of correlations between plasma silicon, magnesium and ionized calcium in OA patients in consideration to gender. Materials and method. The study comprised 59 patients aged 69.5±9.0 years (18 males aged 66.8±9.2; 41 females aged 70.7±8.8), admitted to the Trauma and Orthopaedic Ward of the Independent Public Health Care Centre in Łęczna, Poland, due to OA and qualified to surgery. Control group consisted of 19 subjects without OA (54.5±8.6 years; 10 males aged 41.3±9.3; 9 females aged 69.1±14.9). Plasma concentrations of silicon and magnesium (spectrophotometric methods) and ionized calcium (potentiometric method) were determined. Results. Silicon in OA patients was significantly increased vs. control. In OA males and OA females, silicon was enhanced vs. the respective controls, but it was statistically significant only in males. Magnesium in OA patients was not significantly different from control group. In females, a significant decrease vs. the respective control was observed. No significant differences were observed in the case of ionized calcium. Positive correlations between silicon and magnesium in healthy control, both in the whole group and in male and female subgroups, were noted, while no such effect was observed in OA subjects. Conclusions. The results might suggest some connection between higher OA incidence in women and the depleted magnesium in the organism. Silicon increase in OA patients, especially in men, may indicate its intense metabolism during the articular inflammatory process, likely dependent on sex hormones. It remains open whether the plasma Si increase is the effect or cause of OA.

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Section: Introductionmentioning

confidence: 99%

Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis – analysis in consideration of gender

Musik

Kurzepa

Luchowska-Kocot

et al. 2019

Ann Agric Environ Med.

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“…In a recent clinical trial, Marcowycz et al. reported that following ingestion of one dose of OSA–VC (12.8 mg of Si) the Si serum concentration peaks at ca. 150 μg/L, being in range with Pruska et al.…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of the present study was to investigate the transport mechanism of Si, supplied as an OSA‐vanillin complex (OSA–VC), across the intestinal mucosa using an in vitro model of the human intestinal barrier based on the Caco‐2 cell culture. OSA–VC is a molecule of OSA stabilized by vanillin and was recently shown to be a source of bioavailable Si, increasing the Si levels in the serum and urine of patients supplemented with OSA–VC . OSA is the main form of Si in water and in most plants .…”

Section: Introductionmentioning

confidence: 99%

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In vitro investigation of intestinal transport mechanism of silicon, supplied as orthosilicic acid‐vanillin complex

Sergent¹,

Croizet²,

Schneider³

2016

Molecular Nutrition Food Res

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“…The final pH is adjusted to the value according to the proposed specifications [41]. The EFSA assessed the bioavailability of Si from OSA-VC, taking into account available studies, among others, the Marcowycz et al (2015) [49] research. This study demonstrated a significant increase of silicon concentration in plasma after oral ingestion of OSA-VC by human volunteers, with maximum concentrations obtained after 3 hours from intake.…”

Section: Silicic Acids and Their Stabilized Formsmentioning

confidence: 99%

Sources, Bioavailability, and Safety of Silicon Derived from Foods and Other Sources Added for Nutritional Purposes in Food Supplements and Functional Foods

Sadowska

Świderski

2020

Applied Sciences

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Silicon is a microelement that performs a number of important functions in the human body, being involved in the formation and maintenance of normal osteocartilaginous connective tissue, such as skin, hair, and nails, and having beneficial effects in the prevention of cardiovascular and neurodegenerative diseases. Natural sources of silicon include fruits, vegetables, cereals, and mineral water. European and North American diets are generally low in silicon, which correlates with a diet high in processed foods. Dietary silicon deficiency can be overcome by the consumption of high bioavailability silicon-rich foods and the use of silicon supplements. A good form of supplementation is orthosilicic acid (OSA), usually stabilized by the introduction of a methyl group, choline, or vanillin. OSA is naturally found in diatomaceous earth in the form of amorphous silica and extracts from silicon-rich plants, e.g., horsetail (Eguiseti herba L.) and nettles (Urtica dioica L.). This article presents the characteristics of the various sources of silicon and their bioavailability and safety of use, with particular reference to the sources used in functional foods and dietary supplements. There is a great need to produce functional foods containing dietary silicon, together with other scarce mineral components.

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Digestive absorption of silicon, supplemented as orthosilicic acid–vanillin complex

Abstract: Although many studies have investigated the metabolism and bioavailability of Si supplemented in foods or as a food ingredient, this was the first to investigate and demonstrate the digestibility of OSA administered in a complex form with vanillin.

Cited by 8 publications

References 13 publications

Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis – analysis in consideration of gender

Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis – analysis in consideration of gender

In vitro investigation of intestinal transport mechanism of silicon, supplied as orthosilicic acid‐vanillin complex

Sources, Bioavailability, and Safety of Silicon Derived from Foods and Other Sources Added for Nutritional Purposes in Food Supplements and Functional Foods

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