Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis – analysis in consideration of gender

Abstract

Introduction and objective. Osteoarthrits (OA) is a complex, chronic disorder of cartilage and bone, related to homeostasis of bioelements. The current study aimed at evaluation of correlations between plasma silicon, magnesium and ionized calcium in OA patients in consideration to gender. Materials and method. The study comprised 59 patients aged 69.5±9.0 years (18 males aged 66.8±9.2; 41 females aged 70.7±8.8), admitted to the Trauma and Orthopaedic Ward of the Independent Public Health Care Centre in Łęczna, Poland, due to OA and qualified to surgery. Control group consisted of 19 subjects without OA (54.5±8.6 years; 10 males aged 41.3±9.3; 9 females aged 69.1±14.9). Plasma concentrations of silicon and magnesium (spectrophotometric methods) and ionized calcium (potentiometric method) were determined. Results. Silicon in OA patients was significantly increased vs. control. In OA males and OA females, silicon was enhanced vs. the respective controls, but it was statistically significant only in males. Magnesium in OA patients was not significantly different from control group. In females, a significant decrease vs. the respective control was observed. No significant differences were observed in the case of ionized calcium. Positive correlations between silicon and magnesium in healthy control, both in the whole group and in male and female subgroups, were noted, while no such effect was observed in OA subjects. Conclusions. The results might suggest some connection between higher OA incidence in women and the depleted magnesium in the organism. Silicon increase in OA patients, especially in men, may indicate its intense metabolism during the articular inflammatory process, likely dependent on sex hormones. It remains open whether the plasma Si increase is the effect or cause of OA.

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

“…In the treatment of radiographic knee osteoarthritis, the presence of a high calcium level may possibly have a preventive impact OA. Also, Musik I et al (21), discovered that calcium levels in OA patients were not substantially different from those of the control group; however, this did not correlate with our findings.…”

“…Magnesium levels in OA patients were similarly shown not to be substantially different from those of the control group by Musik I et al (21). In females, a considerable drop compared to the relevant control was detected, and this did not coincide with the findings of our research.…”

Study on the Influencing Factors of Osteoarthritis in Southern China

“…On the one hand, obesity acts to cause OA by increasing the bioburden; on the other hand, intermediate metabolites produced during lipid metabolism (e.g., arachidonic acid) aggravate local inflammation and accelerate the development of OA. In some specific cases, such as ligament injuries, overweight individuals, and age-related muscle weakening, the subchondral bone undergoes potential changes and eventually the overlying articular cartilage is affected [ 34 ].…”

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

“…Different from the results in our study, those obtained Musik et al showed that the Plasma Mg concentrations in patients with osteoarthritis of the spine and those in control subjects were not significantly different. In contrast, there was a significant difference between the concentrations in women in both groups, which may suggest a link between the higher prevalence of the disease in women and Mg deficiency in the body [ 28 ]. However, in our study, there was no difference in serum Mg concentration depending on sex.…”