Digestion-resistant fraction from soybean [Glycine max (L.) Merrill] induces hepatic LDL receptor and CYP7A1 expression in apolipoprotein E-deficient mice

Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient mice

“…In this study, the expression of Cyp7a1 was increased by 2.1-fold (P=.057), while the expression of Cyp7b1 was increased by 1.8-fold (P=.025). Evidence suggests that the expression of cholesterol 7-hydroxylase is regulated by a number of stimuli, including bile acids, steroid hormones, thyroid hormones, cytokines, insulin, retinoids, dietary cholesterol, taurine, 2-aminoethanesulfonic acid and the digestionresistant fraction of soybean [46,[49][50][51]. We have observed an increase in the activity of Cyp7a1 in our previous studies; however, the current study did not confirm a significant up-regulation in gene expression.…”

Increase of Serum Cholesterol Levels by Heat‐Moisture‐Treated High‐Amylose Cornstarch in Rats Fed a High‐Cholesterol Diet

“…In addition, there is a report that the promotion of cholesterol uptake into the liver was a factor for the decreasing effect of resistant starch on the serum cholesterol level [21]. In this present study, no significant increase in bile acid excretion was apparent in any group fed on the HHA diet.…”

Serum Cholesterol-Decreasing Effect of Heat-Moisture-Treated High-Amylose Cornstarch in Cholesterol-Loaded Rats

“…15) In addition, there is a report of the promotion of Chol uptake into the liver being a factor for the decreasing effect of resistant starch on the serum Chol level. 16) In this present study, no significant increase in bile acid excretion was apparent in any group fed on the HHA diet. Therefore, the decrease of serum Chol level in the group fed on the HHA diet with 0.1% Chol could not have been due to the promotion of bile acid excretion, but instead to the …”