Increase of Serum Cholesterol Levels by Heat‐Moisture‐Treated High‐Amylose Cornstarch in Rats Fed a High‐Cholesterol Diet

Udagawa, Haruhide; Kitaoka, Chika; Sakamoto, Tatsuaki; Kobayashi‐Hattori, Kazuo; Oishi, Yoshifumi; Arai, Soichi; Takita, Toshichika

doi:10.1007/s11745-008-3191-4

Cited by 2 publications

(2 citation statements)

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“…They reported dietary resistant starch lost its effect on lowering serum cholesterol when there was a high level of cholesterol in the diet. Coincidently, resistant starch was not fermented in the gut when the dietary cholesterol was high in their study (8, 10). Thus, any factor that may affect colonic fermentation of resistant starch should be considered for the clinical application of resistant starch.…”

Section: Discussionmentioning

confidence: 93%

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Failure to Ferment Dietary Resistant Starch in Specific Mouse Models of Obesity Results in No Body Fat Loss

Zhou¹,

Martin²,

Tulley³

et al. 2009

J. Agric. Food Chem.

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Resistant starch (RS) is a fermentable fiber that decreases dietary energy density and results in fermentation in the lower gut. The current studies examined the effect of RS on body fat loss in mice. In a 12 week study (study 1), the effect of two different types of RS on body fat was compared with two control diets (0% RS) in C57Bl/6J mice: regular control diet or the control diet that had equal energy density as the RS diet (EC). All testing diets had 7% (wt/wt) dietary fat. In a 16 week study (study 2), the effect of RS on body fat was compared with EC in C57BL/6J mice and two obese mouse models (NONcNZO10/LtJ or Non/ShiLtJ). All mice were fed control (0% RS) or 30% RS diet for 6 weeks with 7% dietary fat. On the 7 th week, the dietary fat was increased to 11% for half of the mice, and remained the same for the rest. Body weight, body fat, energy intake, energy expenditure, and oral glucose tolerance were measured during the study. At the end of the studies, the pH of cecal contents was measured as an indicator of RS fermentation. Results: Compared with EC, dietary RS decreased body fat and improved glucose tolerance in C57BL/6J mice, but not in obese mice. For other metabolic characteristics measured, the alterations by RS diet were similar for all three types of mice. The difference in dietary fat did not interfere with these results. The pH of cecal contents in RS fed mice was decreased for C57BL/6J mice but not for obese mice, implying the impaired RS fermentation in obese mice. Conclusion: 1) decreased body fat by RS is not simply due to dietary energy dilution in C57Bl/6J mice, and 2) along with their inability to ferment RS; RS fed obese mice did not lose body fat. Thus, colonic fermentation of RS might play an important role in the effect of RS on fat loss.

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Section: Discussionmentioning

confidence: 93%

“…Incorporating RS into the diet can decrease body fat storage and increase insulin sensitivity ,− in humans. However, opposite results have also been reported , . These equivocal results might be due to differences in dietary components, texture, and energy content between control diets and RS diets used.…”

Section: Introductionmentioning

confidence: 91%