Digestion and Absorption After Massive Resection of the Small Intestine

Althausen, T. L.; Uyeyama, Kahn; Simpson, Roger G.

doi:10.1016/s0016-5085(49)80155-7

Cited by 53 publications

(4 citation statements)

References 17 publications

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“…In 1939, West [18] demonstrated a hypertrophy in the residual intestine of a patient, who 2 years previously, had undergone a massive resection. Similar clinical findings were found by Althausen [19]. Bochkov [20] carried…”

Section: Discussionsupporting

confidence: 90%

A Useful Experimental Model of Short Bowel Syndrome

Pérez

Oliveira

Luy

et al. 2004

Journal of Investigative Surgery

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The short bowel syndrome is a well-known human clinical entity that produces serious metabolic disorders. This syndrome arises after a massive resection of more than 50% of the small intestine, when the intestine attempts to minimize the consequent irregularities by means of compensatory mechanisms. Many reports suggest that an exocrine and endocrine pancreatic dysfunction is associated with enterohormones and an abnormal altered nutrient flow. In this report, we present an experimental model of short bowel syndrome in rats. A massive intestine resection was performed in rats, followed by a histological study of the small intestine. We report the histological changes related to the compensatory changes that occurred in the remaining intestine. The residual intestine produces a hyperplasic response, and hypertrophy was seen in the portion proximal to the anastomosis. We believe this experimental model of short bowel syndrome could be a very useful tool for studying the enterohormonal changes related to an abnormal blood flow of nutrients.

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Section: Discussionsupporting

confidence: 90%

A Useful Experimental Model of Short Bowel Syndrome

Pérez

Oliveira

Luy

et al. 2004

Journal of Investigative Surgery

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“…Butterworth and Perez-Santiago (1958) have found similar changes in the small intestines of patients suffering from tropical sprue and have calculated that the absorptive surface of the jejunum in these patients may be reduced to one-quarter of normal. That this reduction cannot be the only factor in determining intestinal absorption follows from observations on patients who have undergone massive resection of the small intestine; for Althausen et al (1949) reported the case of a patient who later achieved nutritional equilibrium after the removal of all but 10% of his small intestine.…”

Section: Clinical Findingsmentioning

confidence: 99%

Absorption and Elimination of 15N After Administration of Isotopically Labelled Yeast Protein and Yeast Protein Hydrolysate to Adult Patients with Coeliac Disease

Crane¹,

Neuberger²

1960

BMJ

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“…Our experience using metabolic balance techniques has, so far, been confined to patients after operation. Extensive resection of the small intestine or by-pass will lead to malabsorption but not necessarily to malnutrition (Althausen, Uyeyama, and Simpson, 1949;Cooke, 1955). If the remaining bowel is normal, resection of one-third of the small intestine is compatible with normal nutrition with a normal intake.…”

Section: Discussionmentioning

confidence: 99%