A Useful Experimental Model of Short Bowel Syndrome

Abstract

The short bowel syndrome is a well-known human clinical entity that produces serious metabolic disorders. This syndrome arises after a massive resection of more than 50% of the small intestine, when the intestine attempts to minimize the consequent irregularities by means of compensatory mechanisms. Many reports suggest that an exocrine and endocrine pancreatic dysfunction is associated with enterohormones and an abnormal altered nutrient flow. In this report, we present an experimental model of short bowel syndrome in rats. A massive intestine resection was performed in rats, followed by a histological study of the small intestine. We report the histological changes related to the compensatory changes that occurred in the remaining intestine. The residual intestine produces a hyperplasic response, and hypertrophy was seen in the portion proximal to the anastomosis. We believe this experimental model of short bowel syndrome could be a very useful tool for studying the enterohormonal changes related to an abnormal blood flow of nutrients.

Oral Antibiotics Attenuate Bowel Segment Reversal–Induced Systemic Inflammatory Response and Body Weight Loss in Massively Bowel‐Resected Rats

“…To perform the reversal, a 3-cm small bowel segment, which was 3 cm distal to the resected segment, was reversed, and then the remaining jejunum and ileum were constructed by 2 end-to-end anastomotic sutures (Figure 1), as described in the previous study. 17,19 The length and position of the small bowel segment to be reversed did not cause intestinal blockade, as our experience has shown from preliminary experiments and the observation of fecal excretion. One day before the surgery, animals in the ANT group were gavaged with clindamycin and amoxicillin (50 mg/kg and 50 mg/kg dissolved in 0.2 mL of distilled water).…”

Short Bowel Syndrome: Current Medical and Surgical Trends

“…On the other hand in the ileum, where more selective absorption of nutrients is carried out, an increase in the number of transporter cells (hyperplasia) is mandatory. 39 Temporary hypergastrinemia and increased gastric acid secretion occurs in about 50% of patients with extensive intestinal resections. The mechanism has not been clarified, and hypersecretion seems to be temporary.…”

Η Μελέτη Της Επίδρασης Των Προβιοτικών, Πρεβιοτικών, Συμβιοτικών Στον Εντερικό Βλεννογόνο Και Στον Εντερικό Βλεννογονικό Φραγμό Κατά Το Σύνδρομο Του Βραχέος Εντέρου Σε Επίμυες

“…Γη" απηφ ην ιφγν ζηε λήζηηδα, φπνπ ζπληειείηαη ην κεγαιχηεξν κέξνο ηεο απνξξφθεζεο πγξψλ θαη ζξεπηηθψλ ζηνηρείσλ, ιακβάλεη ρψξα κία αχμεζε ηνπ χςνπο ησλ ζειψλ, ρσξίο ζπλνδφ αχμεζε ηνπ αξηζκνχ ησλ εληεξνθπηηάξσλ. Απφ ηελ άιιε ζηνλ εηιεφ, φπνπ δηελεξγείηαη πην εθιεθηηθή απνξξφθεζε ζξεπηηθψλ νπζηψλ, είλαη ππνρξεσηηθή ε αχμεζε ηνπ αξηζκνχ ησλ θπηηάξσλ κεηαθνξάο (ππεξπιαζία) (Collantes Perez et al, 2004).…”