Digestibility and Energy Availability of Wakame(Undaria pinnatifida) Seaweed in Japanese.

Yamada, Yuki; Miyoshi, Tamotsu; Tanada, Seiki; Imaki, Masahide

doi:10.1265/jjh.46.788

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…Furthermore, there are proofs of the microbiota changes when subjected in vitro to the effects of LMW-PS prebiotics from algal origin, such as those from Gelidium , and laminaran and alginate/ALGOS, with the formation of SCFAs [ 61 , 165 , 166 , 167 , 168 ]. Nevertheless, and despite the results obtained from in vitro studies, some positive effects on the number of lactobacteria were observed in pigs fed fucoidans [ 166 , 169 , 170 , 171 ] ( Table 4 ).…”

Section: Seaweeds and Marine Microalgae And Their Active Compoundsmentioning

confidence: 93%

Emergent Sources of Prebiotics: Seaweeds and Microalgae

2016

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In recent years, scientists have become aware that human microbiota, in general, and gut microbiota, in particular, play a major role in human health and diseases, such as obesity and diabetes, among others. A large number of evidence has come to light regarding the beneficial effects, either for the host or the gut microbiota, of some foods and food ingredients or biochemical compounds. Among these, the most promising seem to be polysaccharides (PS) or their derivatives, and they include the dietary fibers. Some of these PS can be found in seaweeds and microalgae, some being soluble fibers, such as alginates, fucoidans, carrageenans and exopolysaccharides, that are not fermented, at least not completely, by colonic microbiota. This review gives an overview of the importance of the dietary fibers, as well as the benefits of prebiotics, to human health. The potential of the PS from marine macro- and microalgae to act as prebiotics is discussed, and the different techniques to obtain oligosaccharides from PS are presented. The mechanisms of the benefits of fiber, in general, and the types and benefits of algal fibers in human health are highlighted. The findings of some recent studies that present the potential effects of prebiotics on animal models of algal biomass and their extracts, as well as oligo- and polysaccharides, are presented. In the future, the possibility of using prebiotics to modulate the microbiome, and, consequently, prevent certain human diseases is foreseen.

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Section: Seaweeds and Marine Microalgae And Their Active Compoundsmentioning

confidence: 93%

Emergent Sources of Prebiotics: Seaweeds and Microalgae

2016

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“…A number of studies indicate biological effects after oral ingestion of sulfated fucans from brown algae (fucoidan) [ 45 ]. Early work on digestion of these polysaccharides suggested that they were not changed by human bacterial flora and were wholly excreted [ 46 , 47 ]. Following oral administration to rats, we observed that fucosylated chondroitin sulfate has anticoagulant and antithrombotic effects, with low hemorrhagic action [ 48 ].…”

Section: Sulfated Polysaccharide With Oral Antithrombotic Effectsmentioning

confidence: 99%

Perspective on the Use of Sulfated Polysaccharides from Marine Organisms as a Source of New Antithrombotic Drugs

Mourāo

2015

Marine Drugs

131

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Thromboembolic diseases are increasing worldwide and always require anticoagulant therapy. We still need safer and more secure antithrombotic drugs than those presently available. Sulfated polysaccharides from marine organisms may constitute a new source for the development of such drugs. Investigation of these compounds usually attempts to reproduce the therapeutic effects of heparin. However, we may need to follow different routes, focusing particularly in the following aspects: (1) defining precisely the specific structures required for interaction of these sulfated polysaccharides with proteins of the coagulation system; (2) looking for alternative mechanisms of action, distinct from those of heparin; (3) identifying side effects (mostly pro-coagulant action and hypotension rather than bleeding) and preparing derivatives that retain the desired antithrombotic action but are devoid of side effects; (4) considering that sulfated polysaccharides with low anticoagulant action on in vitro assays may display potent effects on animal models of experimental thrombosis; and finally (5) investigating the antithrombotic effect of these sulfated polysaccharides after oral administration or preparing derivatives that may achieve this effect. If these aspects are successfully addressed, sulfated polysaccharides from marine organisms may conquer the frontier of antithrombotic therapy and open new avenues for treatment or prevention of thromboembolic diseases.

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“…The expectation that large molecules are not orally absorbed causes difficulties in understanding how apparently systemic effects occur. Early work on digestion of fucoidan suggested that it was not changed by human bacterial flora and was wholly excreted [13,14]. Perhaps systemic observations are partly a result of prebiotic effects?…”

Section: Uptake and Fate Of Fucoidanmentioning

confidence: 99%

Therapies from Fucoidan; Multifunctional Marine Polymers

Fitton¹

2011

Marine Drugs

319

225

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Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.

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Digestibility and Energy Availability of Wakame(Undaria pinnatifida) Seaweed in Japanese.

Cited by 12 publications

References 6 publications

Emergent Sources of Prebiotics: Seaweeds and Microalgae

Emergent Sources of Prebiotics: Seaweeds and Microalgae

Perspective on the Use of Sulfated Polysaccharides from Marine Organisms as a Source of New Antithrombotic Drugs

Therapies from Fucoidan; Multifunctional Marine Polymers

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