Diffusion-weighted MRI in the follow-up of chronic periaortitis

Abstract

Objective: To evaluate the usefulness of diffusion-weighted MRI (DWI) for the assessment of the intraindividual follow-up in patients with chronic periaortitis (CP) under medication. Methods: MRI data of 21 consecutive patients with newly diagnosed untreated disease were retrospectively examined before and after medical therapy, with a median follow-up of 16 weeks. DWI parameters [b800 signal, apparent diffusion coefficient (ADC) values] of the CP and psoas muscle were analysed together with the extent and contrast enhancement. Pre-and post-treatment laboratory inflammation markers were acquired parallel to each MR examination.

A prospective study comparing whole-body skeletal X-ray survey with 18F-FDG-PET/CT, 18F-NaF-PET/CT and whole-body MRI in the detection of bone lesions in multiple myeloma patients

“…As known from treatment monitoring studies in other diseases, corticosteroids may result in decreased FDG uptake representing decreased bone marrow activity after successful treatment (18)(19)(20). Similarly, lower signal intensities and higher ADC values have been observed after steroid treatment on DWI MRI (21). In daily clinical practice, however, myeloma patients have often initiated steroid therapy at time of imaging due to their clinical condition.…”

High Signal Intensity in Arterial Walls on Diffusion-Weighted Magnetic Resonance Imaging in the Active Phase of Takayasu Arteritis

“…periaortitis before and after either prednisone or tamoxifen treatment. 3 The periaortic fibrous tissue had high signal intensity on DWI, which resolved with treatment. Normal tissues, including spinal cord, bone marrow, and spleen, as well as neoplastic and inflammatory lesions, show low diffusion.…”

Retroperitoneal Fibrosis and its Differential Diagnoses: The Role of Radiological Imaging

“…Auch die diffusionsgewichteten Sequenzen zeigen mit hohen Signalintensitäten und korrespondierend niedrigem Signal in der ADC-Map ein typisches Signalverhalten in einer aktiven RPF [25][26][27]. Kamper et al konnten in einer Studie mit 21 Patienten einen signifikanten Abfall der b800-Signalintensität und höhere ADC-Werte in der DWI nachweisen [28]. Speziell bei Patienten mit eingeschränkter Nierenfunktion oder bei Patienten in jungem Alter kann die MRT durch den Verzicht auf Strahlenexposition und potenziell auch auf Kontrastmittel wichtige Informationen liefern, da die DWI-Sequenzen sehr nützlich in der Bewertung eines akuten Stadiums der RPF sind [27,29].…”