Diffusion-weighted MRI abnormalities in an outbreak of<i>Streptococcus agalactiae</i>Serotype III, multilocus sequence type 283 meningitis

Tan, Kevin; Wijaya, Limin; Chiew, Hui Jin; Sitoh, Yih Yian; Shafi, Humaira; Chen, Robert C.; Goh, Chin Kong; Lim, Charles

doi:10.1002/jmri.25373

Cited by 16 publications

(16 citation statements)

References 39 publications

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“…and served as a side dish with porridge by food stalls within larger eating establishments. Persons with severe clinical cases had meningoencephalitis, bacteremia, and septic arthritis ( 2 – 4 ). GBS, or Streptococcus agalactiae , was identified as the causative agent ( 2 , 3 ).…”

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confidence: 99%

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Group B Streptococcus Infections Caused by Improper Sourcing and Handling of Fish for Raw Consumption, Singapore, 2015–2016

Chau¹,

Chen²,

Yap³

et al. 2017

Emerg. Infect. Dis.

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confidence: 99%

“…GBS is found in ≈30% of healthy adults ( 5 ) and is a member of the human commensal gastrointestinal and genitourinary flora ( 4 ). GBS is a common cause of neonatal sepsis, is acquired by newborns from the vaginal flora of the mother, and is an increasingly common pathogen among vulnerable populations ( 6 ).…”

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confidence: 99%

Group B Streptococcus Infections Caused by Improper Sourcing and Handling of Fish for Raw Consumption, Singapore, 2015–2016

Chau¹,

Chen²,

Yap³

et al. 2017

Emerg. Infect. Dis.

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“…This finding was comparable to various studies that also reported similar associations between GBS infections and bacteraemia. (8,19,22) In addition, our results showed that patients with GBS septic arthritis were more likely to have significantly higher CRP values, with 95.2% of these patients having CRP > 150 mg/L. In contrast, only 71.0% of patients with septic arthritis from non-GBS microorganisms had CRP > 150 mg/L on univariate analysis (p = 0.017).…”

Section: Discussionmentioning

confidence: 60%

“…Invasive GBS infections in healthy adults are not as common compared to severe infections in pregnant women, neonates, the elderly and immunocompromised individuals. (5,12,(14)(15)(16)(17)(18)(19) Previous studies have described GBS causing bovine mastitis (20) and disease in fish. (21) However, our understanding of the links between the routes and likelihood of interspecies transmission and invasive disease in humans remains lacking.…”

Section: Discussionmentioning

confidence: 99%

A comparison of Streptococcus agalactiae septic arthritis and non-Streptococcus agalactiae septic arthritis

Wang

Tan

Pay

et al. 2018

smedj

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INTRODUCTION Streptococcus agalactiae (Group B Streptococcus, GBS) is an uncommon cause of septic arthritis in the adult population. In recent years, there has been an increase in the incidence of GBS septic arthritis. This study aims to compare the clinical presentation, investigations, microbiology and outcome of management in patients with GBS and non-GBS septic arthritis. METHODS Retrospective review of hospital surgical records was done to identify all patients treated surgically at our institution from January 2011 to January 2016 for primary septic arthritis. Patients were categorised into two groups: those with culture-proven GBS septic arthritis and those with causative pathogens that were not GBS. Patients who were medically unfit for surgical intervention as well as those who declined interventional procedures were excluded from the study. RESULTS A total of 83 patients were included in the study: 62 (74.7%) had non-GBS septic arthritis and 21 (25.3%) had GBS septic arthritis. Patients with GBS septic arthritis were more likely to have polyarticular involvement (p < 0.001) and involvement of less common sites such as the elbow joint. They were also more likely to have elevated inflammatory markers (C-reactive protein > 150 mg/L; p = 0.017) and positive blood cultures (p = 0.02), and were typically healthy adults with no medical comorbidities (p = 0.012). CONCLUSION Patients with GBS septic arthritis were more likely to present with polyarticular involvement, positive blood cultures and higher levels of C-reactive protein on admission, and tended to be healthier individuals with no medical comorbidities.

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“…It has been shown that consumption of fish is associated with an increased risk of GBS colonization in people (Foxman et al, 2007 ). In 2015, an outbreak of GBS infection was related to consuming infected raw freshwater fish, which affected more than 200 patients in Singapore (Tan et al, 2017 ). Thus, it is proposed that some strains of aquatic GBS may present a zoonotic or anthroponotic hazard and the fish may be a reservoir of pathogenic GBS.…”

Section: Introductionmentioning

confidence: 99%

Pathogenicity of Human ST23 Streptococcus agalactiae to Fish and Genomic Comparison of Pathogenic and Non-pathogenic Isolates

Wang

Huang

et al. 2017

Front. Microbiol.

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Streptococcus agalactiae, or Group B Streptococcus (GBS), is a major pathogen causing neonatal sepsis and meningitis, bovine mastitis, and fish meningoencephalitis. CC23, including its namesake ST23, is not only the predominant GBS strain derived from human and cattle, but also can infect a variety of homeothermic and poikilothermic species. However, it has never been characterized in fish. This study aimed to determine the pathogenicity of ST23 GBS to fish and explore the mechanisms causing the difference in the pathogenicity of ST23 GBS based on the genome analysis. Infection of tilapia with 10 human-derived ST23 GBS isolates caused tissue damage and the distribution of pathogens within tissues. The mortality rate of infection was ranged from 76 to 100%, and it was shown that the mortality rate caused by only three human isolates had statistically significant difference compared with fish-derived ST7 strain (P < 0.05), whereas the mortality caused by other seven human isolates did not show significant difference compared with fish-derived ST7 strain. The genome comparison and prophage analysis showed that the major genome difference between virulent and non-virulent ST23 GBS was attributed to the different prophage sequences. The prophage in the P1 region contained about 43% GC and encoded 28–39 proteins, which can mediate the acquisition of YafQ/DinJ structure for GBS by phage recombination. YafQ/DinJ belongs to one of the bacterial toxin–antitoxin (TA) systems and allows cells to cope with stress. The ST23 GBS strains carrying this prophage were not pathogenic to tilapia, but the strains without the prophage or carrying the pophage that had gene mutation or deletion, especially the deletion of YafQ/DinJ structure, were highly pathogenic to tilapia. In conclusion, human ST23 GBS is highly pathogenic to fish, which may be related to the phage recombination.

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Diffusion-weighted MRI abnormalities in an outbreak ofStreptococcus agalactiaeSerotype III, multilocus sequence type 283 meningitis

Abstract: 4 J. Magn. Reson. Imaging 2017;45:507-514.

Cited by 16 publications

References 39 publications

Group B Streptococcus Infections Caused by Improper Sourcing and Handling of Fish for Raw Consumption, Singapore, 2015–2016

Group B Streptococcus Infections Caused by Improper Sourcing and Handling of Fish for Raw Consumption, Singapore, 2015–2016

A comparison of Streptococcus agalactiae septic arthritis and non-Streptococcus agalactiae septic arthritis

Pathogenicity of Human ST23 Streptococcus agalactiae to Fish and Genomic Comparison of Pathogenic and Non-pathogenic Isolates

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