Diffusion Tensor Imaging Study of the Anterior Limb of Internal Capsules in Neuroleptic-Naive Schizophrenia

Liqiu, Zou; Yuan, Huishu; Pei, Xin-long; Dong, Wei; Liu, Pengcheng; Xie, Jing

doi:10.1016/j.acra.2007.09.026

Cited by 46 publications

(40 citation statements)

References 12 publications

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“…[4][5][6][7][8] Different from other studies of first-episode antipsychotic drug-naïve patients with schizophrenia, [4][5][6][7][8][9] we observed that patients also showed regions of increased FA and decreased MD values, likely reflecting structural "hyperconnectivity," 18 mainly in the brain stem, cerebellum, and in the interhemispheric and cortico-cortical WM connections. Some studies of patients with schizophrenia have found a similar pattern of DTI changes.…”

Section: Wm Findingscontrasting

confidence: 54%

“…It is clear that studies based on untreated patients enrolled at an early stage of the disease represent the easiest and most rewarding strategy to overcome such an issue. To date, however, only a few studies [4][5][6][7][8][9] have adopted this strategy showing WM changes compared with healthy participants in a variable pattern of brain regions including the splenium of the corpus callosum, 4,6 superior longitudinal fasciculus, 7,8 anterior 9 and posterior 4 limbs of the internal capsule, and fronto-occipital fasciculus. 4 The relevance of DTI abnormalities in the early phase of schizophrenia is further supported by the positive association between positive symptoms and fractional anisotropy (FA) values of the superior and inferior longitudinal fasciculi and inferior fronto-occipital fasciculus in never-medicated patients with schizophrenia.…”

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confidence: 99%

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Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

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Section: Wm Findingscontrasting

confidence: 54%

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confidence: 99%

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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“…This may reflect reduced axonal number or packing density, cellular membrane abnormalities that increase permeability including possible loss of myelin, or inconsistent fiber orientation. These findings may be confounded by exposure to nonclozapine psychotropic medications; however, concurrent findings in studies involving subjects who are naive to psychotropic medication (Cheung et al, 2008;Gasparotti et al, 2009;Karlsgodt et al, 2009;Perez-Iglesias et al, 2010a;Zou et al, 2008) supporting the hypothesis that a portion of these deficits are due to the pathophysiology of schizophrenia. Postmortem studies provide support for a contribution of reduced axonal packing density, abnormal glial cell arrangement or function, and reduced myelin in schizophrenia.…”

Section: Discussionmentioning

confidence: 54%

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Holleran

Ahmed

Anderson‐Schmidt

et al. 2013

Neuropsychopharmacol

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Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and temporal WM. Using tract-based spatial statistics (TBSS), we examined diffusion parameters in a sample of patients with severe chronic schizophrenia. Diffusion MRI data were acquired on 19 patients with chronic severe schizophrenia and 19 age-and gender-matched healthy controls using a 64 gradient direction sequence, (b ¼ 1300 s/mm 2 ) collected on a Siemens 1.5T MRI scanner. Diagnosis of schizophrenia was determined by Diagnostic and Statistical Manual for Mental Disorders 4th Edition (DSM-IV) Structured Clinical Interview for DSM disorder (SCID). Patients were treatment resistance, having failed to respond to at least two antipsychotic medications, and had prolonged periods of moderate to severe positive or negative symptoms. Analysis of diffusion parameters was carried out using TBSS. Individuals with chronic severe schizophrenia had significantly reduced FA with corresponding increased radial diffusivity in the genu, body, and splenium of the corpus callosum, the right posterior limb of the internal capsule, right external capsule, and the right temporal inferior longitudinal fasciculus. There were no voxels of significantly increased FA in patients compared with controls. A decrease in splenium FA was shown to be related to a longer illness duration. We detected widespread abnormal diffusivity properties in the callosal and temporal lobe WM regions in individuals with severe chronic schizophrenia who have not previously been exposed to clozapine. These deficits can be driven by a number of factors that are indistinguishable using in vivo diffusion-weighted imaging, but may be related to reduced axonal number or packing density, abnormal glial cell arrangement or function, and reduced myelin.

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“…16 In a previous study, we found that patients with MDD who had a history of suicide attempts had more severe microstructural white matter alterations in the left ALIC than other depressed patients. 12 Moreover, the ALIC has been reported to be involved in multiple psychiatric disorders, particularly schizophrenia, 17,18 obsessive-compulsive disorder (OCD), 19 and major depression. 20 Furthermore, the ALIC is the most frequent therapeutic target when deep brain stimulation is used clinically for treatment-resistant depression and OCD.…”

Section: Introductionmentioning

confidence: 99%

Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

Jia

Wang

Huang

et al. 2014

J Psychiatry Neurosci

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IntroductionSuicide is one of the leading causes of death in children and middle-aged individuals and represents a major public health problem throughout the world. Current trends suggest that about 1.5 million people will die by suicide in the year 2020.1 Major depressive disorder (MDD) is a highly prevalent, etiologically multifactorial and clinically heterogen eous disorder. The lifetime risk of suicide in patients with MDD is about 6%, which represents a 20-fold increase from the general population.2,3 Suicide attempts, defined as selfdestructive acts with some degree of intent to end one's life, are one of the strongest predictors of future suicidal acts. 4,5 Thus, suicide attempts represent an important intervention point for suicide prevention efforts, and in vivo studies of individuals who attempt suicide represent an important strategy for learning about the neurobiology of suicide.Conventional magnetic resonance imaging (MRI) studies have found white matter and grey matter hyperintensities and reduced orbitofrontal cortex grey matter volumes on scans of depressed patients with a history of suicide attempts.6-8 A functional MRI experiment revealed that suicidal patients were distinguished from nonsuicidal patients in their activation patterns in frontal, cingulate and cerebellar regions.9 A positron emission tomography study revealed localized prefrontal hypofunction and impaired responsivity of serotonergic systems to pharmaco logic al challenge that were proportional to the lethality of the suicide attempt in individuals with MDD. Background:The neurobiology of suicide is largely unknown. Studies of white matter tracts in patients with a history of suicidal behaviour have shown alteration in the left anterior limb of the internal capsule (ALIC). Our aim was to determine whether particular target fields of fibre projections through the ALIC are affected in depressed patients who recently attempted suicide. Methods: We studied patients with major depressive disorder (MDD) with and without a history of suicide attempts and healthy controls using diffusion tensor imaging (DTI) and deterministic tractography to generate fibre tract maps for each participant. Tract voxels were coded as being unique to the left ALIC. We compared the mean percentage of fibres projecting to relevant brain regions in the 3 groups using analysis of covariance. Results: We included 63 patients with MDD (23 with and 40 without a history of suicide attempts) and 46 controls in our study. Both groups of depressed patients had reduced fibre projections through the ALIC to the left medial frontal cortex, orbitofrontal cortex and thalamus. Those with a history of suicide attempts had greater abnormalities than those without suicide attempts in the left orbitofrontal cortex and thalamus. Limitations: Diffusion tensor imaging deterministic tracking is unable to distinguish between afferent and efferent pathways, limiting our ability to distinguish the directionality of altered fibre tracts. Conclusion: Frontothalamic loops passing throu...

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Diffusion Tensor Imaging Study of the Anterior Limb of Internal Capsules in Neuroleptic-Naive Schizophrenia

Cited by 46 publications

References 12 publications

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

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