Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi, Massimo; Canu, Elisa; Gasparotti, Roberto; Agosta, Federica; Valsecchi, Paolo; Lodoli, Giovanni; Galluzzo, Alessandro; Comi, Giancarlo; Sacchetti, Emilio

doi:10.3174/ajnr.a3583

Cited by 64 publications

(58 citation statements)

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“…Generally, patients with schizophrenia have smaller temporal, parietal, and occipital gray matter. In addition, they have ventriculomegaly, and cortical and subcortical volume loss (2). Brain matter loss and neurodegeneration are involved in the pathophysiology of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 99%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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“…Outro fator bastante importante a ser ponderado na análise destes resultados é a possível existência de alterações cerebrais microestruturais potencialmente reversíveis e estado-dependentes em transtornos psicóticos (Keshavan et al, 1998;Busatto et al, 2009;Schaufelberger et al, 2011), ou seja, alterações que estejam diretamente relacionadas a fase da doença (aguda versus estável) (Busatto et al, 2009;Bora et al, 2010 (Cheung et al, 2008;Gasparotti et al, 2009;Guo et al, 2012;Wang et al, 2013;Filippi et al, 2014;Ebdrup et al, 2016;Zeng et al, 2016). Um único estudo demonstrou áreas de aumento de FA em pacientes PEP versus CS afetando diferentes tratos de SB, como FLS direito, cápsula externa direita, seguimento posterior da cápsula interna direita, pedúnculos cerebrais e cerebelares, ponte e bulbo (Filippi et al, 2014).…”

Section: -Limitações Dos Estudos De Dti Préviosunclassified

“…Um único estudo demonstrou áreas de aumento de FA em pacientes PEP versus CS afetando diferentes tratos de SB, como FLS direito, cápsula externa direita, seguimento posterior da cápsula interna direita, pedúnculos cerebrais e cerebelares, ponte e bulbo (Filippi et al, 2014).…”

Section: -Limitações Dos Estudos De Dti Préviosunclassified

“…Assim como em pacientes crônicos, poucos estudos com pacientes PEP avaliaram medidas de difusão (Ruef et al, 2012;Lee et al, 2013;Filippi et al, 2014;Zeng et al, 2016). Apenas dois deles foram conduzidos com pacientes virgens de tratamento.…”

Section: -Limitações Dos Estudos De Dti Préviosunclassified

“…Apesar de ser uma investigação com um grupo de sujeitos ainda sem um diagnóstico de transtorno psicótico estabelecido, tais achados são convergentes com nossa visão de que mudanças em índices de DTI poderiam de alguma forma refletir processos neurobiológicos relacionados à psicose aguda. (Ruef et al, 2012;Lee et al, 2013;Filippi et al, 2014;Zeng et al, 2016). Lee et al (2013) (Ruef et al, 2012;Lee et al, 2013;Zeng et al, 2016), não houve correlações entre os índices de difusividade e o nível de sintomas; apenas Filippi et al (2014) encontrou correlações inversas entre MD e sintomas.…”

Section: -Análises Estatísticas Longitudinaisunclassified

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Avaliação longitudinal de alterações microestruturais cerebrais estado-dependentes em indivíduos com primeiro episódio psicótico, associadas à atividade da enzima fosfolipase A2

Serpa

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An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

Hawkins

Wood

Vernon

et al. 2017

Human Brain Mapping

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Chronic administration of antipsychotic drugs has been linked to structural brain changes observed in patients with schizophrenia. Recent MRI studies have shown rapid changes in regional brain volume following just a single dose of these drugs. However, it is not clear if these changes represent real volume changes or are artefacts ("apparent" volume changes) due to drug-induced physiological changes, such as increased cerebral blood flow (CBF). To address this, we examined the effects of a single, clinical dose of three commonly prescribed antipsychotics on quantitative measures of T1 and regional blood flow of the healthy human brain. Males (n 5 42) were randomly assigned to one of two parallel groups in a double-blind, placebo-controlled, randomized, three-period cross-over study Additional Supporting Information may be found in the online version of this article. design. One group received a single oral dose of either 0.5 or 2 mg of risperidone or placebo during each visit. The other received olanzapine (7.5 mg), haloperidol (3 mg), or placebo. MR measures of quantitative T1, CBF, and T1-weighted images were acquired at the estimated peak plasma concentration of the drug. All three drugs caused localized increases in striatal blood flow, although drug and region specific effects were also apparent. In contrast, all assessments of T1 and brain volume remained stable across sessions, even in those areas experiencing large changes in CBF. This illustrates that a single clinically relevant oral dose of an antipsychotic has no detectable acute effect on T1 in healthy volunteers. We further provide a methodology for applying quantitative imaging methods to assess the acute effects of other compounds on structural MRI metrics. Hum Brain Mapp 39:319-331, 2018.V C 2017 Wiley Periodicals, Inc.

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Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Cited by 64 publications

References 44 publications

Elevated nucleosome level and oxidative stress in schizophrenia patients

Elevated nucleosome level and oxidative stress in schizophrenia patients

Avaliação longitudinal de alterações microestruturais cerebrais estado-dependentes em indivíduos com primeiro episódio psicótico, associadas à atividade da enzima fosfolipase A2

An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers

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