Diffusion tensor imaging quantifying the severity of chronic hepatitis in rats

Huang, Mengping; Lu, Xin; Shu, Jiwu

doi:10.1186/s12880-020-00466-3

Cited by 6 publications

(2 citation statements)

References 28 publications

(43 reference statements)

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“…FA reflects the direc- Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations e139 © Pol J Radiol 2023; 88: e135-e140 tion of water diffusion across tissue microstructure, and this depends mainly on tissue orientation [24][25][26]. Surprisingly, the literature contains studies reporting positive [27] and negative correlations [28,29] between FA and the degree of liver fibrosis. The previous heterogenicity related to FA findings could be attributed to the complex histopathological changes associated with fibrosis, such as inflammation, fatty infiltration, as well as extracellular collagen breakdown.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations

Elhawary¹,

Elmansy²,

Ali³

et al. 2023

Pol J Radiol

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Purpose: Liver biopsy is still the standard method for the diagnosis of ductal plate malformations (DPM). However, it is an invasive tool. Magnetic resonance imaging (MRI) has shown its accuracy in the diagnosis of this pathology. Herein, a study was conducted to elucidate the role of diffusion MRI parameters in predicting the degree of hepatic fibrosis. Material and methods:This prospective study included 29 patients with DPM and 20 healthy controls. Both groups underwent diffusion tensor magnetic resonance imaging (DT-MRI), and its parameters were compared between patients and controls, and then they were correlated with the degree of liver fibrosis in the patient group. Results:All patients with DPM, whatever its type, expressed a significantly lower hepatic apparent diffusion coefficient (ADC) compared to controls. However, fractional anisotropy (FA) showed no significant difference between them. The ADC value of 1.65 × 10 -3 mm 2 /s had sensitivity and specificity of 82.1% and 90%, respectively, in differentiating DPM patients from healthy controls. It was evident that patients with higher fibrosis grades had significantly lower hepatic ADC, indicating a negative correlation between ADC and the grade of hepatic fibrosis; rs = -0.901, p < 0.001. Conclusions:DT-MRI showed good efficacy in the diagnosis of congenital DPM. Moreover, ADC could be applied to monitor the degree of liver fibrosis rather than the invasive liver biopsy. No significant correlation was noted between the FA and the grades of liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations

Elhawary¹,

Elmansy²,

Ali³

et al. 2023

Pol J Radiol

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“…Limited studies discuss the role of shear-wave elastography, magnetic resonance (MR) elastography, and MR spectroscopy in the diagnosis and monitoring of patients with AIH, but these results are preliminary and overlapping [10][11][12][13]. Diffusion tensor imaging (DTI) provides in-vivo tissue microstructure information by measuring the water diffusivity for a given voxel that can be represented by parameters such as the mean diffusivity (MD) and the fractional anisotropy (FA) [14][15][16][17][18][19][20][21]. Some studies have reported that DWI is a promising technique in the detection and quantification of hepatic inflammation and fibrosis in adults and children [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The role of diffusion tensor imaging of the liver in children with autoimmune hepatitis

et al. 2021

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Purpose:To evaluate the role of diffusion tensor imaging (DTI) of the liver in children with autoimmune hepatitis (AIH). Material and methods:A prospective study was done on 42 children with AIH (30 girls and 12 boys, with a mean age of 13 years) and 20 age-and sex-matched healthy control children. They underwent DTI of the liver and laboratory tests. Liver biopsy was done for the patients. The mean diffusivity (MD) and fractional anisotropy (FA) of the liver were calculated and correlated with the pathological results. Results:The mean MD and FA of the liver in children with AIH were 1.42 ± 0.06 × 10 -3 mm²/s and 0.37 ± 0.11; and in the control children they were 1.55 ± 0.07 × 10 -3 mm²/s and 0.25 ± 0.03, respectively. The MD and FA were significantly different in the children with AIH compared to the control children (p = 0.001). The cutoff MD and FA used to differentiate patients from controls were 1.50 × 10 -3 mm²/s, 0.31 with AUC of 0.919 and 0.813, sensitivity of 97.6% and 66.7%, a specificity of 80% and 70%, an accuracy of 94.2% and 67.3%, PPV of 95.3 and 90.3, and NPV of 88.9 and 33.3, respectively. There was significantly lower MD and higher FA of the liver in children with AIH type I (n = 31) than type II (n = 11) (p = 0.001), and patients with (n = 9) and without (n = 33) overlap syndrome (p = 0.005). Conclusions:We concluded that DTI parameters can help to diagnose AIH, detect its phenotyping, and give clues as to the presence of associated overlap syndrome.

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Advancements of non‐invasive imaging technologies for the diagnosis and staging of liver fibrosis: Present and future

Huang,

Peng,

Kang

2024

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Liver fibrosis is a reparative response triggered by liver injury. Non‐invasive assessment and staging of liver fibrosis in patients with chronic liver disease are of paramount importance, as treatment strategies and prognoses depend significantly on the degree of fibrosis. Although liver fibrosis has traditionally been staged through invasive liver biopsy, this method is prone to sampling errors, particularly when biopsy sizes are inadequate. Consequently, there is an urgent clinical need for an alternative to biopsy, one that ensures precise, sensitive, and non‐invasive diagnosis and staging of liver fibrosis. Non‐invasive imaging assessments have assumed a pivotal role in clinical practice, enjoying growing popularity and acceptance due to their potential for diagnosing, staging, and monitoring liver fibrosis. In this comprehensive review, we first delved into the current landscape of non‐invasive imaging technologies, assessing their accuracy and the transformative impact they have had on the diagnosis and management of liver fibrosis in both clinical practice and animal models. Additionally, we provided an in‐depth exploration of recent advancements in ultrasound imaging, computed tomography imaging, magnetic resonance imaging, nuclear medicine imaging, radiomics, and artificial intelligence within the field of liver fibrosis research. We summarized the key concepts, advantages, limitations, and diagnostic performance of each technique. Finally, we discussed the challenges associated with clinical implementation and offer our perspective on advancing the field, hoping to provide alternative directions for the future research.

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Diffusion tensor imaging quantifying the severity of chronic hepatitis in rats

Cited by 6 publications

References 28 publications

Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations

Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations

The role of diffusion tensor imaging of the liver in children with autoimmune hepatitis

Advancements of non‐invasive imaging technologies for the diagnosis and staging of liver fibrosis: Present and future

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