Diffusion Tensor Imaging of Spinocerebellar Ataxias Types 1 and 2

Mandelli, Maria Luisa; Simone, Tiziana De; Minati, Ludovico; Bruzzone, Maria Grazia; Mariotti, Caterina; Fancellu, Roberto; Savoiardo, M.; Grisoli, Marina

doi:10.3174/ajnr.a0716

Cited by 65 publications

(75 citation statements)

References 25 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, microstructural abnormalities measured by diffusion weighted imaging have been detected in the cerebellum and the pons28 as well as cortical alterations in SCA2 patients 10, 11, 29. Functional MRI in resting‐state modus further shows changes of cerebellar but also fronto‐ and parietal connectivity networks related to cognitive and motor performance 30, 31.…”

Section: Discussionmentioning

confidence: 78%

Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2

Reetz

Rodríguez‐Labrada²,

Dogan

et al. 2018

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveSpinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disease mainly affecting the cerebellum and brainstem. In this Cuban‐German research collaboration, we aimed to characterize atrophy patterns and associations with clinical measures in preclinical and manifest SCA2.MethodsIn this study, 16 nonmanifest SCA2 mutation carriers, 26 manifest patients with SCA2, and 18 healthy control subjects underwent magnetic resonance imaging, as well as genetic and clinical characterization including assessment of ataxia (Scale for the Assessment and Rating of Ataxia) and saccade velocity in Cuba were enrolled. Semiautomated quantitative volumetry of the cerebellum and brainstem, subdivided into the medulla oblongata, the pontine brainstem, and mesencephalon was performed. Additionally, the anteroposterior diameter of the pontine brainstem was measured.ResultsAnalysis of volumetric data revealed degeneration of the cerebellum and brainstem, in particular of pontine volumes and the anteroposterior diameter of the pons, in both manifest SCA2 patients and individuals at risk for SCA2 compared to controls. Comparing patients with nonataxic preclinical SCA2 mutation carriers, we found more pronounced reductions of the pontine brainstem and cerebellum in manifest SCA2. Volumetric data further showed associations with CAG repeat length and predicted age of onset in preclinical SCA2 individuals, and by trend with ataxia signs in patients. Although saccade velocity was associated with reduction in the pontine brainstem in preclinical and manifest SCA2, reduced ability to suppress interfering stimuli measured by the Stroop task was related to cerebellar volume loss in patients.InterpretationPreclinical SCA2 mutation carriers exhibit brain abnormalities, which could be targeted as surrogate parameters for disease progression and in future preventive trials.

show abstract

Section: Discussionmentioning

confidence: 78%

Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2

Reetz

Rodríguez‐Labrada²,

Dogan

et al. 2018

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…In addition to MD and FA, other water diffusion properties such as axial diffusivity and radial diffusivity have been reported in previous studies, including SCA1, SCA2, and Friedreich ataxia. 10,29 In this work, we focused on the analyses of FA and MD because the other measurements are subcomponents of the apparent diffusion coefficient. Furthermore, several studies of patients with neurodegenerative diseases have suggested that MD is more useful and sensitive to neurodegeneration than the other measurements.…”

Section: Discussionmentioning

confidence: 99%

Ataxia Severity Correlates with White Matter Degeneration in Spinocerebellar Ataxia Type 7

Hernandez‐Castillo

Vaca‐Palomares²,

Barrios

et al. 2016

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…CP region of interest was chosen because 1) it mediates the communication of neuronal networks including telencephala, rhombencephala, and spinal cord (corticospinal tract); and 2) in adult cohorts, CP alteration has been described in patients with poor neurologic outcome in traumatic brain injury, in spinocerebellar ataxia types 1 and 2, and in stroke. [25][26][27] In each case, anatomic landmarks for selected regions of interest were positioned according to Wakana et al 22 However, regions of interest drawn on DTI may have low resolution, but the high interrater and intrarater reliability demonstrates the reproducibility of the method.…”

Section: Methodologic Considerationsmentioning

confidence: 99%

Efficiency of Fractional Anisotropy and Apparent Diffusion Coefficient on Diffusion Tensor Imaging in Prognosis of Neonates with Hypoxic-Ischemic Encephalopathy: A Methodologic Prospective Pilot Study

Brissaud

Amirault²,

Villega³

et al. 2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:The DTI parameters (FA and ADC) reflect the properties of the brain microstructure. Decreased anisotropy is a common feature of cerebral tissue abnormalities. Our study investigates the neurologic prognostic efficiency of these parameters in white (PLIC, CP) and gray matter (PP) in the first days of life in term neonates with HIE. We hypothesize that lesions in related brain areas could be part of a physiopathologic substratum supporting neurologic deficiencies in this population.

show abstract

Diffusion Tensor Imaging of Spinocerebellar Ataxias Types 1 and 2

Cited by 65 publications

References 25 publications

Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2

Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2

Ataxia Severity Correlates with White Matter Degeneration in Spinocerebellar Ataxia Type 7

Efficiency of Fractional Anisotropy and Apparent Diffusion Coefficient on Diffusion Tensor Imaging in Prognosis of Neonates with Hypoxic-Ischemic Encephalopathy: A Methodologic Prospective Pilot Study

Contact Info

Product

Resources

About