Efficiency of Fractional Anisotropy and Apparent Diffusion Coefficient on Diffusion Tensor Imaging in Prognosis of Neonates with Hypoxic-Ischemic Encephalopathy: A Methodologic Prospective Pilot Study

Brissaud, Olivier; Amirault, Marion; Villega, Frédéric; Periot, O.; Chateil, Jean‐François; Allard, Michèle

doi:10.3174/ajnr.a1805

Cited by 38 publications

(37 citation statements)

References 34 publications

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“…Consistent with previous reports, we found that FA values do not pseudonormalize after HIE (28), Malik et al reported a correlation between FA in the corticospinal tract and DQ at 3 mo of age, both in control infants and those who had experienced HIE, but no correlation was found in any other regions (29). Brissaud et al found that FA values in the cerebral peduncles and PLIC correlate with early neurologic function during the first week after birth (26). However, these studies used manually defined regions of interest, an approach that can potentially introduce observer error.…”

Section: Imaging Biomarkers After Hiesupporting

confidence: 80%

“…The utility of ADC measurements in HIE is limited due to pseudonormalization: typically, ADC values are lower during the first week after HIE, then return to normal, and increase further after ~2 wk; therefore postnatal age at scanning must be taken into account (18)(19)(20)(21)(22)(23). Although in several studies an ADC value of <0.78-0.85 × 10 −3 mm 2 /s in the PLIC was associated with poor outcome (22,(24)(25)(26), a recent meta-analysis of MRI biomarkers in asphyxia showed that ADC has poor specificity (64%) and sensitivity (66%) in predicting outcome (27). Consistent with previous reports, we found that FA values do not pseudonormalize after HIE (28), Malik et al reported a correlation between FA in the corticospinal tract and DQ at 3 mo of age, both in control infants and those who had experienced HIE, but no correlation was found in any other regions (29).…”

Section: Imaging Biomarkers After Hiementioning

confidence: 99%

“…Neurodevelopmental assessments using the GMDS-R were carried out on 32 of the 34 surviving children, including 2 with CP, at a median age of 24 mo (range: [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. The mean ± SD DQ was 91 ± 19 and the mean ± SD quotients for the subscales were as follows: locomotor, 92 ± 23; personal-social, 100 ± 24; hearing and language, 87 ± 24; eye-hand coordination, 86 ± 18; and performance, 85 ± 17.…”

Section: Neurodevelopmental Outcomementioning

confidence: 99%

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Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics

et al. 2012

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IntroductIon:Objective biomarkers are needed to assess neuroprotective therapies after perinatal hypoxic-ischemic encephalopathy (hIe). We tested the hypothesis that, in infants who underwent therapeutic hypothermia after perinatal hIe, neurodevelopmental performance was predicted by fractional anisotropy (Fa) values in the white matter (WM) on early diffusion tensor imaging (DTI) as assessed by means of tract-based spatial statistics (TBss). Methods: We studied 43 term infants with hIe. Developmental assessments were carried out at a median (range) age of 24 (12-28) mo. results: as compared with infants with favorable outcomes, those with unfavorable outcomes had significantly lower Fa values (P < 0.05) in the centrum semiovale, corpus callosum (cc), anterior and posterior limbs of the internal capsule, external capsules, fornix, cingulum, cerebral peduncles, optic radiations, and inferior longitudinal fasciculus. In a second analysis in 32 assessable infants, the Griffiths Mental Development scales (Revised) (GMDs-R) showed a significant linear correlation (P < 0.05) between Fa values and developmental quotient (DQ) and all its component subscale scores. dIscussIon: DTI analyzed by TBss provides a qualified biomarker that can be used to assess the efficacy of additional neuroprotective therapies after hIe.

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Section: Imaging Biomarkers After Hiesupporting

confidence: 80%

Section: Imaging Biomarkers After Hiementioning

confidence: 99%

Section: Neurodevelopmental Outcomementioning

confidence: 99%

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Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics

et al. 2012

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“…24 -26 Two studies correlated these findings with neurodevelopmental outcome during the first weeks of life 25 up to months, 24 but none reported long-term outcome, including the development of UMD.…”

Section: Discussionmentioning

confidence: 99%

Does Diffusion Tensor Imaging-Based Tractography at 3 Months of Age Contribute to the Prediction of Motor Outcome After Perinatal Arterial Ischemic Stroke?

Leemans

Northington³

et al. 2011

Stroke

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Background and Purpose-After perinatal arterial ischemic stroke, diffusion-weighted imaging (DWI) and early evaluation of spontaneous motor behavior can be used to predict the development of unilateral motor deficits. The aim of this study was to investigate whether diffusion tensor imaging-based tractography at 3 months of age contributes to this prediction. Methods-Twenty-two infants with unilateral perinatal arterial ischemic stroke were included and scanned during the neonatal period. DWI was used to assess restricted diffusion in the cerebral peduncle. At the age of 3 months, diffusion tensor imaging-based tractography of the corticospinal tracts was performed along with assessment of the movement repertoire. The role of DWI, diffusion tensor imaging, and motor assessment in predicting unilateral motor deficits were compared by calculating the positive and negative predictive values for each assessment. Results-Eleven infants (50%) showed abnormal motor behavior at 3 months with subsequent development of unilateral motor deficits in 8 as determined at follow-up (9 -48 months, positive predictive value 73%). Diffusion tensor imaging-based tractography correctly predicted the development of unilateral motor deficits in all 8 infants (positive predictive value 100%). A diagnostic neonatal DWI was available in 20 of 22 (91%) infants. Seven infants showed an abnormal DWI, resulting in unilateral motor deficits in 6 infants (positive predictive value 86%). All assessments had a negative predictive value of 100%. Conclusions-Diffusion tensor imaging-based tractography at 3 months can be used to predict neurodevelopmental outcome after perinatal arterial ischemic stroke. It has a similar predictive value as DWI in the neonatal period and can especially be of additional value in case of an indecisive neonatal DWI or unexpected abnormal early motor development. (Stroke. 2011;42:3410-3414.)

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“…Indeed, the impact that FA and ADC values in this region have on outcome after ischemic injuries has been extensively described in neonates [27,28].…”

Section: Discussionmentioning

confidence: 99%

Evolution of diffusion tensor imaging parameters after acute subarachnoid haemorrhage: a prospective cohort study

et al. 2016

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Introduction Few studies assessed diffusion tensor imaging (DTI) changes in the acute phase of subarachnoid haemorrhage (SAH). We prospectively evaluated DTI parameters in the acute phase of SAH and 8-10 days after and analysed whether changes could be related to SAH severity or to the development of delayed cerebral ischemia (DCI). Methods Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) changes over time were assessed in a prospective cohort of patients with acute SAH. Two MRI studies were performed at <72 h (MRI-1) and 8-10 days (MRI-2). DTI parameters were recorded in 15 ROIs. Linear mixed regression models were used.

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Efficiency of Fractional Anisotropy and Apparent Diffusion Coefficient on Diffusion Tensor Imaging in Prognosis of Neonates with Hypoxic-Ischemic Encephalopathy: A Methodologic Prospective Pilot Study

Cited by 38 publications

References 34 publications

Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics

Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics

Does Diffusion Tensor Imaging-Based Tractography at 3 Months of Age Contribute to the Prediction of Motor Outcome After Perinatal Arterial Ischemic Stroke?

Evolution of diffusion tensor imaging parameters after acute subarachnoid haemorrhage: a prospective cohort study

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