Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging

Profant, Oliver; Škoch, Antonín; Balogová, Zuzana; Tintěra, Jaroslav; Hlinka, Jaroslav; Syka, Josef

doi:10.1016/j.neuroscience.2013.12.010

Cited by 89 publications

(102 citation statements)

References 79 publications

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“…8,9 To our knowledge, only 1 study has reported a lack of white matter integrity in patients with mild presbycusis by applying an intergroup statistic on the ROI-based features, which was in the form of reconstructed auditory tracts. 6 Besides that, the study showed no obvious differences in any measured DTI parameters between mild presbycusis and expressed presbycusis. Although promising, a more reliable imaging marker of presbycusis could be established by designing more sophisticated experiments.…”

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confidence: 60%

“…One study has demonstrated that the right hemisphere was the dominant hemisphere involved in pitch perception 26 ; and 2) Another study found a clear rightward asymmetry in the white matter under the auditory cortex in patients with presbycusis. 6 To our knowledge, only 1 study has used a DTI-based technique to investigate microstructural changes in the white matter of patients with presbycusis. 6 In that study, the DA value was increased in the right-side auditory pathway of patients with mild presbycusis compared with young healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…6 To our knowledge, only 1 study has used a DTI-based technique to investigate microstructural changes in the white matter of patients with presbycusis. 6 In that study, the DA value was increased in the right-side auditory pathway of patients with mild presbycusis compared with young healthy controls. Therefore, the altered integrity of the auditory pathway might be mainly caused by aging.…”

Section: Discussionmentioning

confidence: 99%

“…However, there were no differences in any measured DTI parameters between patients with mild presbycusis and expressed presbycusis in the previous study. 6 Except for the selection of ROI sizes (the minimal size of an ROI is a single voxel), as mentioned in the introduction, the contradiction in results might be explained by differences in the patient populations.…”

Section: Discussionmentioning

confidence: 99%

“…In a structural MR imaging study, the volume and surface area were decreased in the auditory cortex areas of patients with presbycusis compared with young healthy controls. 6 In a functional MR imaging study, patients with presbycusis showed higher blood oxygen level-dependent activation in response to acoustic stimuli in the temporal lobes compared with young healthy controls. 7 The aforementioned imaging markers were mainly explored in gray matter, whereas white matter integrity, as one of the most sensitive indicators of axon damage or demyelination, requires further study.…”

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confidence: 99%

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DTI Analysis of Presbycusis Using Voxel-Based Analysis

Ma¹,

Li²,

Gao³

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data.

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confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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DTI Analysis of Presbycusis Using Voxel-Based Analysis

Ma¹,

Li²,

Gao³

et al. 2016

AJNR Am J Neuroradiol

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Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss

Armstrong

Doshi

et al. 2019

JAMA Otolaryngol Head Neck Surg

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Association of Poorer Hearing With Longitudinal Change in Cerebral White Matter Microstructure

Armstrong

Williams

Landman

et al. 2020

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE There is a dearth of studies that examine the association between poorer hearing and change in cerebral white matter (WM) microstructure.OBJECTIVE To examine the association of poorer hearing with baseline and change in WM microstructure among older adults. DESIGN, SETTING, AND PARTICIPANTSThis was a prospective cohort study that evaluated speech-in-noise, pure-tone audiometry, and WM microstructure, as measured by mean diffusivity (MD) and fractional anisotropy (FA), both of which were evaluated by diffusion tensor imaging (DTI) in 17 WM regions. Data were collected between October 2012 and December 2018 and analyzed between March 2019 and August 2019 with a mean follow-up time of 1.7 years. The study evaluated responses to the Baltimore Longitudinal Study of Aging among 356 cognitively normal adults who had at least 1 hearing assessment and DTI session. Excluded were those with baseline cognitive impairment, stroke, head injuries, Parkinson disease, and/or bipolar disorder.EXPOSURES Peripheral auditory function was measured by pure-tone average in the better-hearing ear. Central auditory function was measured by signal-to-noise ratio score from a speech-in-noise task and adjusted by pure-tone average. MAIN OUTCOMES AND MEASURESLinear mixed-effects models with random intercepts and slopes were used to examine the association of poorer peripheral and central auditory function with baseline and longitudinal DTI metrics in 17 WM regions, adjusting for baseline characteristics (age, sex, race, hypertension, elevated total cholesterol, and obesity). RESULTSOf 356 cognitively normal adults included in the study, the mean (SD) age was 73.5 (8.8) years, and 204 (57.3%) were women. There were no baseline associations between hearing and DTI measures. Longitudinally, poorer peripheral hearing was associated with increases in MD in the inferior fronto-occipital fasciculus (β = 0.025; 95% CI, 0.008-0.042) and the body (β = 0.050; 95% CI, 0.015-0.085) of the corpus callosum, but there were no associations of peripheral hearing with FA changes in these tracts. Poorer central auditory function was associated with longitudinal MD increases (β = 0.031; 95% CI, 0.010-0.052) and FA declines (β = −1.624; 95% CI, −2.511 to −0.738) in the uncinate fasciculus.CONCLUSIONS AND RELEVANCE Findings of this cohort study suggest that poorer hearing is related to change in integrity of specific WM regions involved with auditory processing.

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Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging

Cited by 89 publications

References 79 publications

DTI Analysis of Presbycusis Using Voxel-Based Analysis

DTI Analysis of Presbycusis Using Voxel-Based Analysis

Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss

Association of Poorer Hearing With Longitudinal Change in Cerebral White Matter Microstructure

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