DTI Analysis of Presbycusis Using Voxel-Based Analysis

Ma, Wen; Li, M.; Gao, Fei; Zhang, X.; Shi, Le; Yu, Lili; Zhao, Bin; Chen, W.; Wang, G.; Wang, X.

doi:10.3174/ajnr.a4870

Cited by 24 publications

(30 citation statements)

References 37 publications

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“…Actually, this has not been tested so far although non-invasive tractography techniques like diffusion tensor imaging (DTI) are readily available in humans. However, more general DTI studies on normal aging (e.g., Salat et al, 2005 ; Giorgio et al, 2010 ; Yang et al, 2016 ) and studies on specific age-related sensory losses like presbycusis (e.g., Lutz et al, 2007 ; Profant et al, 2014 ; Ma et al, 2016 ) and glaucoma (e.g., Boucard et al, 2016 ) consistently revealed reduced subcortical and cortical white matter tracts and a decreasing fractional anisotropy (i.e., directionality of myelinated fibers) in sensory pathways of elderly humans, which may be indicative for reduced uni- and crossmodal connections.…”

Section: Discussionmentioning

confidence: 99%

Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging

Henschke

Ohl

Budinger

2018

Front. Aging Neurosci.

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During aging, human response times (RTs) to unisensory and crossmodal stimuli decrease. However, the elderly benefit more from crossmodal stimulus representations than younger people. The underlying short-latency multisensory integration process is mediated by direct crossmodal connections at the level of primary sensory cortices. We investigate the age-related changes of these connections using a rodent model (Mongolian gerbil), retrograde tracer injections into the primary auditory (A1), somatosensory (S1), and visual cortex (V1), and immunohistochemistry for markers of apoptosis (Caspase-3), axonal plasticity (Growth associated protein 43, GAP 43), and a calcium-binding protein (Parvalbumin, PV). In adult animals, primary sensory cortices receive a substantial number of direct thalamic inputs from nuclei of their matched, but also from nuclei of non-matched sensory modalities. There are also direct intracortical connections among primary sensory cortices and connections with secondary sensory cortices of other modalities. In very old animals, the crossmodal connections strongly decrease in number or vanish entirely. This is likely due to a retraction of the projection neuron axonal branches rather than ongoing programmed cell death. The loss of crossmodal connections is also accompanied by changes in anatomical correlates of inhibition and excitation in the sensory thalamus and cortex. Together, the loss and restructuring of crossmodal connections during aging suggest a shift of multisensory processing from primary cortices towards other sensory brain areas in elderly individuals.

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Section: Discussionmentioning

confidence: 99%

Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging

Henschke

Ohl

Budinger

2018

Front. Aging Neurosci.

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“…Neuroimaging technique has been applied to investigate the anatomical and functional alterations in the brains of patients with presbycusis (Mudar and Husain, 2016 ). Gray matter (GM) atrophy and white matter (WM) lesions, common structural abnormalities observed in previous studies, are modestly linked with presbycusis-related cognitive decline (Peelle et al, 2011 ; Eckert et al, 2012 ; Lin et al, 2014 ; Profant et al, 2014 ; Ma et al, 2016 ). Gamma-aminobutyric acid (GABA) levels in the auditory cortex, an important inhibitory neurotransmitter that can be assessed by magnetic resonance spectroscopy (MRS), were negatively correlated with the degree of age-related hearing loss (Gao et al, 2015 ).…”

Section: Introductionmentioning

confidence: 95%

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI

Chen

Jiang

et al. 2018

Front. Behav. Neurosci.

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Purpose: Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functional magnetic resonance imaging (fMRI) approach.Methods: Hearing and resting-state fMRI measurements were obtained from 22 presbycusis patients and 23 age-, sex- and education-matched healthy controls. To identify changes in spontaneous neural activity associated with age-related hearing loss, we compared the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of fMRI signals in presbycusis patients vs. controls and then determined if these changes were linked to clinical measures of presbycusis.Results: Compared with healthy controls, presbycusis patients manifested decreased spontaneous activity mainly in the superior temporal gyrus (STG), parahippocampal gyrus (PHG), precuneus and inferior parietal lobule (IPL) as well as increased neural activity in the middle frontal gyrus (MFG), cuneus and postcentral gyrus (PoCG). A significant negative correlation was observed between ALFF/ReHo activity in the STG and average hearing thresholds in presbycusis patients. Increased ALFF/ReHo activity in the MFG was positively correlated with impaired Trail-Making Test B (TMT-B) scores, indicative of impaired cognitive function involving the frontal lobe.Conclusions: Presbycusis patients have disrupted spontaneous neural activity reflected by ALFF and ReHo measurements in several brain regions; these changes are associated with specific cognitive performance and speech/language processing. These findings mainly emphasize the crucial role of aberrant resting-state ALFF/ReHo patterns in presbycusis patients and will lead to a better understanding of the neuropathological mechanisms underlying presbycusis.

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“…However, in the former study, the sample size was rather low and the statistical threshold liberal, whereas the latter study also covered congenital, noise-induced and drug-induced hearing impairments and was not restricted to an age-related decline in hearing abilities. Another DTI study identified increased diffusivity, but decreased FA in auditory areas as well as increased diffusivity in language-related areas in participants with age-related hearing loss (Ma et al 2016). Sample size was relatively low in this study as well (n = 15).…”

Section: Introductionmentioning

confidence: 60%

“…Further, (ii) grey matter volume and cortical thickness in the prefrontal cortex should be negatively associated with self-rated daily life listening effort such that with high experienced listening effort there is a thinning of cortical thickness and loss of grey matter volume (Giroud et al 2018;Rudner et al 2019;Wong et al 2010). Regarding white matter integrity, we expected (iii) decreased FA values in association tracts connecting auditory and prefrontal as well as visual areas-for instance, superior and inferior frontooccipital and longitudinal fasciculi as well as in cingulum and uncinate fasciculus-in hard-of-hearing compared to normal-hearing participants (Husain et al 2011;Luan et al 2019b;Ma et al 2016). Similarly, we hypothesized (iv) a negative association between white matter integrity in the aforementioned regions and self-rated listening effort, i.e.…”

Section: Introductionmentioning

confidence: 96%

“…The assessment of cortical thickness may therefore be of interest as additional neural measure to support the development of treatment or rehabilitation options in age-related hearing loss. White matter integrity-as supposed to reflect axon damage or demyelination-has previously gained only minute attention with respect to research in hearing loss (Ma et al 2016), whereas its role in age-related decline and cognitive functioning in healthy adults has been already acknowledged (Madden et al 2009(Madden et al , 2013. Further, the plastic nature of white matter integrity, for instance, in response to cognitive training shown by Lövdén et al (2010), may offer valuable implications for diagnosing and treating age-related cognitive disorders, which might also apply to age-related hearing loss (Madden et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Neuroanatomical changes associated with age-related hearing loss and listening effort

Rosemann

Thiel

2020

Brain Struct Funct

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Age-related hearing loss is associated with a decrease in hearing abilities for high frequencies and therefore leads to impairments in understanding speech—in particular, under adverse listening conditions. Growing evidence suggests that age-related hearing loss is related to various neural changes, for instance, affecting auditory and frontal brain regions. How the decreased auditory input and the increased listening effort in daily life are associated with structural changes is less clear, since previous evidence is scarce and mostly involved low sample sizes. Hence, the aim of the current study was to investigate the impact of age-related untreated hearing loss and subjectively rated daily life listening effort on grey matter and white matter changes in a large sample of participants (n = 71). For that aim, we conducted anatomical MRI and diffusion tensor imaging (DTI) in elderly hard-of-hearing and age-matched normal-hearing participants. Our results showed significantly lower grey matter volume in the middle frontal cortex in hard-of-hearing compared to normal-hearing participants. Further, higher listening effort was associated with lower grey matter volume and cortical thickness in the orbitofrontal cortex and lower grey matter volume in the inferior frontal cortex. No significant relations between hearing abilities or listening effort were obtained for white matter integrity in tracts connecting auditory and prefrontal as well as visual areas. These findings provide evidence that hearing impairment as well as daily life listening effort seems to be associated with grey matter loss in prefrontal brain regions. We further conclude that alterations in cortical thickness seem to be linked to the increased listening effort rather than the hearing loss itself.

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DTI Analysis of Presbycusis Using Voxel-Based Analysis

Cited by 24 publications

References 37 publications

Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging

Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI

Neuroanatomical changes associated with age-related hearing loss and listening effort

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