Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles

Siepmann, Juergen; Lecomte, Florence; Bodmeier, Roland

doi:10.1016/s0168-3659(99)00093-0

Cited by 158 publications

(86 citation statements)

References 26 publications

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“…All plasticizers used in this study are commonly used for the application of polymer coatings as well as for matrix systems [31][32][33][45][46][47]. Triethylcitrate (TEC) is the standard plasticizer for Eudragit RS with a maximum water solubility of 5 percent, underlining its hydrophilic character.…”

Section: I) Numerical Determination Of Solubility Propertiesmentioning

confidence: 99%

“…Its aromatic molecular structure presents a further change in the geometry as well as in the hydrophilic-lipophilic character. In contrast, the antiasthmatic methylxanthine theophylline has proven its inertness within formulations containing Eudragit RS [31][32][33][34] and was therefore chosen as the second active ingredient in our study.…”

Section: I) Numerical Determination Of Solubility Propertiesmentioning

confidence: 99%

“…In this follow-up study we want to examine the miscibility and the impact on the drug dosage form in respect of T g from systems including Eudragit ® RS (a cationic ammonio methacrylate copolymer; type B), three common plasticizers (triethyl citrate, acetyltributyl citrate, and dibutyl sebacate) and two active ingredients: ibuprofen (likely plasticizing impact on Eudragit RS [30]) and theophylline (unlikely plasticizing influence on Eudragit RS [31,[32][33][34]). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion

Maus

Wagner

Kornherr³

et al. 2008

Molecular Simulation

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Section: I) Numerical Determination Of Solubility Propertiesmentioning

confidence: 99%

Section: I) Numerical Determination Of Solubility Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion

Maus

Wagner

Kornherr³

et al. 2008

Molecular Simulation

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“…Another reason for this high release could be explained by the choice of plasticizer, DBS. This plasticizer was demonstrated as an appropriate one for a more rapid in vitro release (32).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Studies on Transdermal Delivery Enhancement of Zidovudine

2009

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Abstract. The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method from methanol/acetone solvent mixture. The release studies were carried out by vertical Franz cells (2.2 cm 2 area, 20 ml receptor fluid). Ex vivo studies were done on Wistar rat skin within the films F6 (Eudragit RL100) and F7 (Eudragit RL100/Ethylcellulose, 1:1) consisting 5% (w/w) zidovudine in comparison with the same amount of free drug. Either iontophoresis (0.1 and 0.5 mA/cm 2 direct currents, Ag/AgCl electrodes) or dimethyl sulfoxide (pretreatment of 1% and 5%, w/w, solutions) were used as enhancers. Films consisting of ethyl cellulose under the ratio of 50% (w/w) gave similar release profiles, and the highest in vitro cumulative released amount was achieved with F6 film which gave the closest results with the free drug. This result could be due to the high swelling capacity and recrystallization inhibition effect of RL 100 polymer which also influenced the film homogenization. All the films were fitted to Higuchi release kinetics. It was also observed that both 0.5-mA/cm 2 current and 5% (w/w) dimethyl sulfoxide applications significantly increased the cumulative permeated amount of zidovudine after 8 h; however, the flux enhancement ratio was higher for 0.5-mA/cm 2 current application, especially within F6 film. Thus, it was concluded that Eudragit RL100 film (F6) could be further evaluated for the transdermal application of zidovudine.

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“…Controlled release systems have been mainly developed for pharmaceutical applications (Langer and Peppas, 1981;Leong and Langer, 1988;Brayden, 2003). Different strategies for achieving controlled release of drugs are well established and studies on both preparation and modeling of drug delivery systems have been reported (Langer and Peppas, 1981;Mallapragada and Peppas, 1997;Richard, 1998;Siepmann et al, 1999;Siepmann and Peppas, 2001; Arifin et al, 2006). However, studies on the development of food packaging films with controlled release properties are limited.…”

Section: Introductionmentioning

confidence: 99%

Development of cellulose acetate based antimicrobial food packaging materials for controlled release of lysozyme

Gemili

Yemenicioğlu

Altınkaya

2009

Journal of Food Engineering

181

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a b s t r a c tAntimicrobial packaging materials were obtained by incorporation of lysozyme into cellulose acetate (CA) films. In order to achieve controlled release of lysozyme, the structure of the films was changed from highly asymmetric and porous to dense by modulating the composition of the initial casting solution. The highest release rate, soluble lysozyme activity and antimicrobial activity were obtained with the film prepared from 5% CA solution including 1.5% lysozyme. Increasing CA content in the casting solution decreased the porosity of the films, hence, reduced the release rate, maximum released lysozyme activities and the antimicrobial activities of the films. In contrast, immobilized lysozyme activities and the tensile strength of the films increased. The incorporation of lysozyme did not cause significant reductions in tensile strength and elongation at break values except in films prepared with 15% CA. This study showed the good potential of asymmetric CA films to achieve controlled release in antimicrobial packaging.

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Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles

Cited by 158 publications

References 26 publications

Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion

Molecular dynamics simulations for drug dosage form development: thermal and solubility characteristics for hot-melt extrusion

Studies on Transdermal Delivery Enhancement of Zidovudine

Development of cellulose acetate based antimicrobial food packaging materials for controlled release of lysozyme

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