Diffusion and adsorption in arrested‐flow chromatography

Oh, Moonsoo; Smith, J. M.; McCoy, Benjamin J.

doi:10.1002/aic.690350723

Cited by 10 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…Knox and McLaren 29 rst introduced this technique in 1964 to measure the diffusion coefficient and obstructive factors in gas chromatography. Peak parking has since been used to study the mass transfer kinetics in a number of gaseous [30][31][32] and liquid [33][34][35][36][37][38][39] phase systems. In 2006, Gritti and Guiochon 40 used the peak parking technique on ve C18 particle packed columns with different carbon loadings and noted that a higher surface coverage led to slower axial diffusion.…”

Section: Introductionmentioning

confidence: 99%

A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

et al. 2015

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Section: Introductionmentioning

confidence: 99%

A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

et al. 2015

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“…The arrested flow or stopped flow method has been used for some kinetic properties in various GC and LC systems (20)(21)(22)(23)(24)(25). Recently, the PP-MA method has also been applied to the kinetic study on the mass transfer in RPLC systems using C 18 -silica monolithic columns and conventional columns packed with full-porous C 18 -silica spherical particles (26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

Surface Diffusion in C18-Silica Monolithic Stationary Phase

Miyabe

2009

Journal of Chromatographic Science

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A peak parking-moment analysis method was used for the measurement of surface diffusion coefficient (D(s)) in a reversed-phase liquid chromatography (RPLC) system consisting of a C(18)-silica monolithic column and a mixture of methanol and water (70/30, v/v). The D(s) values experimentally measured were analyzed by considering the correlation with corresponding values of molecular diffusivity (D(m)) and the retention equilibrium constant (K(a)). It seems that the correlation between D(s)/D(m) and K(a) is represented by a single curve irrespective of the RPLC conditions of temperature and the type of sample compounds. The increase in K(a) is accompanied with the decrease in D(s)/D(m). Oppositely, the ratio of D(s)/D(m) increases and approaches around unity when K(a) infinitely decreases. It seems that surface diffusion is originally similar to molecular diffusion and that it is restricted due to the sample retention. These characteristics of surface diffusion are the same between the C(18)-silica monolithic stationary phase and the conventional C(18)-silica gel particles. In addition, the values of K(a) and D(s) are also comparable between them. It is concluded that basic properties concerning the retention equilibrium and surface diffusion of the C(18)-silica monolithic stationary phase are almost the same as those of the conventional C(18)-silica gel particles in spite of the difference between their structural characteristics.

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“…19 It is also called "stopped flow method" and "arrested flow method". This method has been used for some studies on the kinetic properties in gaseous 21,22 and liquid phase systems. 23,24 Information about the mass transfer in the stationary phase can be derived from the PP experimental data.…”

Section: Introductionmentioning

confidence: 99%

Moment Analysis of Chromatographic Behavior of Superficially Porous Particles

2011

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Peak parking experiments were conducted to study the chromatographic behavior in a RPLC system consisting of a column packed with superficially porous C18-particles and a mixture of methanol and water (70/30, v/v). The values of the surface diffusion coefficient and the retention equilibrium constant of a column packed with superficially porous C18-particles were comparable to those of columns packed with a C18-silica monolith and full-porous C18-silica gel particles. The flow-rate dependence of HETP was hypothetically calculated by using moment equations to clarify the influence of the structural characteristics on the chromatographic behavior. The column efficiency of a column packed with the superficially porous particles is higher in the high flow-rate range than that with full-porous spherical particles. This is attributed to the smaller contribution of the intraparticulate mass transfer in the superficially porous particles to band broadening. The moment equations are effective for the quantitative analysis of chromatographic behavior of superficially porous particles.

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Diffusion and adsorption in arrested‐flow chromatography

Cited by 10 publications

References 4 publications

A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

Surface Diffusion in C18-Silica Monolithic Stationary Phase

Moment Analysis of Chromatographic Behavior of Superficially Porous Particles

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