Diffuse sclerosing variant of papillary thyroid carcinoma—clinical features and outcome

Chow, Sin Ming; Chan, J.K.C.; Law, Stephen C.K.; Tang, Dong; Ho, Cheryl; Cheung, W Y; Wong, I.S.M.; Lau, W.S.

doi:10.1016/s0748-7983(03)00005-2

Cited by 90 publications

(70 citation statements)

References 11 publications

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“…These US features may be due to collapse of the cystic cavity, infarction of the solid component, and other destructive processes such as hemorrhage, followed by replacement by fibrous tissue. 17 These pathologic alterations may appear on US as marked hypoechogenicity of a nodule with ill-defined margins.…”

mentioning

confidence: 99%

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Jeong²,

Shong³

et al. 2011

AJNR Am J Neuroradiol

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mentioning

confidence: 99%

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Jeong²,

Shong³

et al. 2011

AJNR Am J Neuroradiol

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“…The number of such phenotypes decreased at 6 months and totally disappeared at 10 months. We wonder whether it may correspond to the rare human young age 'diffused sclerosing' variant (Chow et al, 2003), with its mesenchymal remodeling and inflammatory background, or as found by Russell et al (2004) in the RET/PTC3 mouse in the strain background C57 BL/6.…”

Section: Discussionmentioning

confidence: 99%

Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice

et al. 2008

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Human rearranged RET/PTC3 (papillary thyroid carcinoma) proto-oncogene and high-risk human papillomavirus (HPV) type 16 E7 oncogene induces in the mouse a neoplastic transformation of thyroid follicular cells. We present a detailed immuno-histological study (170 mouse thyroids: RET/PTC3, E7, wild type, 2-to 10-month-old) with cell cycle proliferation and signalling pathway indicators. The characteristics of both models are different. There is an 'oncogene dependent' cellular signature, maintained at all studied ages in the E7 model, less in the RET/PTC3 model. During tumour development a large heterogeneity occurred in the Tg-RET/PTC3 model within a same tumour or within a same thyroid lobe. The Tg-E7 model was less heterogeneous, with a dominant goitrous pattern. The solid tumour already described in the RET/PTC3 models associated with cribriform patterns, suggested 'PTC spindle cell changes' as in humans PTC rather than the equivalent of the solid human PTC. Proliferation and apoptosis in the two thyroid models are related to the causal oncogene rather than reflect a general tumorigenic process. The thyroids of RET/PTC3 mice appeared as a partial and transient model of human PTCs, whereas the Tg-E7 mice do not belong to the usual PTC type.

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“…La mayoría son tumores duros, blanco grisáceos, de bordes irregulares y con evidente infi ltración del parénquima del tiroides vecino, con tamaños que varían desde algunos milímetros hasta varios centímetros 29 . En Chile no se ha descrito la incidencia de las variedades de cáncer papilar, el pronóstico descrito en la literatura extranjera para cada una de ellas es contradictorio [3][4][5][6][7][8][9][10] . En esta serie identifi camos que las variedades más frecuentes de CPT son papilar puro y la variedad folicular, constituyendo ambos el 90% de los casos, (objetivo 1 del estudio).…”

Section: Discussionunclassified

“…Los subtipos con mejor pronóstico corresponden a las formas papilares puras, variedad folicular 3 y encapsulado 4,5 . Los CPT con peor pronóstico corresponden a la variedad esclerosante 6,7 , de células altas [8][9][10] y no encapsulado 9 . Las variedades microcarcinoma y pobremente diferenciada, muestran resultados contradictorios.…”

Section: Factores Pronóstico De Las Variantes De Cáncer Papilar De Tiunclassified

Factores pronóstico de las variantes de cáncer papilar de tiroides

et al. 2010

Rev Chil Cir

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Association between pathological variants of papillary thyroid cancer and prognosis Background: Papillary thyroid carcinoma had a survival over 90% in stages I , II and III. Treatment failures are observed in advanced tumors, when there is lymph node involvement or when there is vascular invasion. Aim: To assess the prognostic value of pathological variants of papillary thyroid carcinoma. Material and Methods: Review of pathological records of patients with papillary thyroid cancer operated between January 1999 and December 2008 in a regional hospital. The pathological variant of the tumor was revised and classifi ed again as follicular variant, sclerosing, solid, tall cell variant, columnar variant, oncocytic, cribriform, microcarcinoma, insular variant and poorly differentiated. Results: The records of 51 females aged 48 ± 16 years and 12 males aged 42 ± 18 years were identifi ed. Forty patients had a well differentiated carcinoma (63%), 16 had a follicular variant (25%), four had a sclerosing variant and three other types. Capsule involvement was observed in six of 27 stage I, four of nine stage II, 20 of 26 stage III and one of one stage four tumor. Peritumoral lymphatic invasion was observed in 12 of 27 stage I, four of nine stage II, 21 of 26 stage III and one of one stage IV tumor. Lymph node relapse was observed in three patients without and nine patients with capsule involvement (p < 0.01) and in 11 of 38 patients without and 27 of 38 patients with lymphatic invasion (p < 0.01). Two patients in stage III and one in stage IV died. Lethality was 3%. Conclusions: Relapse of papillary carcinoma was associated with capsule involvement and lymphatic invasion. Tumor variants were not associated with relapse or mortality

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Diffuse sclerosing variant of papillary thyroid carcinoma—clinical features and outcome

Cited by 90 publications

References 11 publications

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice

Factores pronóstico de las variantes de cáncer papilar de tiroides

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