Diffuse reflectance spectroscopy: a clinical study of tuberculin skin tests reading

Koenig, Anne; Grande, Sophie; Dahel, Karima; Planat-Chrétien, Anne; Poher, V.; Goujon, Catherine; Dinten, Jean‐Marc

doi:10.1117/12.2002314

Cited by 8 publications

(12 citation statements)

References 8 publications

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“…Various ways to implement srDRS have been reported in the literature. 1,5,[12][13][14][15][16] Most common srDRS instruments involve a broadband source and a spectrophotometer, both coupled to a fiber-optic probe ensuring light delivery and collection directly in contact with tissue. This approach has led to the development of portable instruments that have been deployed in a variety of clinical and preclinical studies.…”

Section: Introductionmentioning

confidence: 99%

“…This approach has led to the development of portable instruments that have been deployed in a variety of clinical and preclinical studies. 5,16,17 Typical fiber-based probes consist of a concentric arrangement of multiple collection fibers around a central illumination fiber for maximization of signalto-noise ratio (SNR), 5,16 as shown in Fig. 1(a).…”

Section: Introductionmentioning

confidence: 99%

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Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

et al. 2018

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Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, current fiber-based and photodiode-based systems have difficulties achieving this goal due to challenges in sampling the reflectance with a high enough resolution. We introduce a compact, low-cost architecture for srDRS based on the use of a multipixel imaging sensor and light-emitting diodes to achieve lensless diffuse reflectance imaging in contact with the tissue with high spatial resolution. For proof-of-concept, a prototype device, involving a commercially available complementary metal-oxide semiconductor coupled with a fiber-optic plate, was fabricated. Diffuse reflectance profiles were acquired at 645 nm at source-to-detector separations ranging from 480 μm to 4 mm with a resolution of 16.7 μm. Absorption coefficients (μ a ) and reduced scattering coefficients (μ 0 s ) of homogeneous tissue-mimicking phantoms were measured with 4.2 AE 3.5% and 7.0 AE 4.6% error, respectively. The results obtained confirm the potential of our approach for quantitative characterization of tissue optical properties in contact imaging modality. This study is a first step toward the development of low-cost, wearable devices for skin condition diagnosis in vivo.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

et al. 2018

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“…The simulation describes photons travelling through a semi-infinite medium and measured at the medium's surface, under contact conditions. The essential principle for the calculation of the optical properties through the DRS system described in [6] lies in the reflectance correlation of an unknown sample with respect to a reference phantom. With the known optical properties µ s and µ a of the reference phantom, the simulated diffusion reflectance, expressed as a function of the measurement distance, can be determined and compared to the experimental reflectance measurement.…”

Section: Methods and Signal Correctionsmentioning

confidence: 99%

“…SRR is measured with a probe featuring a central illumination fibre and concentric detection fibres at 6 different distances as described in the contact DRS system reported in [6] and shown in Fig. 1a.…”

Section: Experimental Set-upmentioning

confidence: 99%

Non-contact quantitative diffuse reflectance spectroscopy

Sorgato

Berger

Emain

et al. 2015

Diffuse Optical Imaging V

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We validate a non-contact Diffuse Reflectance Spectroscopy (DRS) system as a first stage to approach quantitative multi-spectral imaging technique. The non-contact DRS system with separated illumination and detection paths was developed with different progressive set-ups which were all compared to a well-founded contact DRS system. While quantitation of the absorption coefficient is well achieved with the existing method, the calculation of the scattering coefficient is deteriorated by the non-contact architecture measurements. We have therefore developed an adaptive reference-based algorithm to compensate for this effect.

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“…We have developed a low-cost optical instrument based upon the spatially resolved diffuse reflectance spectroscopy [4] to detect in vivo delayed hypersensitivity reaction (occurrence of an erythema and an induration) either in a clinical environment or at a point of care. The first addressed application was tuberculosis skin tests reading [5].…”

Section: Introductionmentioning

confidence: 99%

Accessing deep optical properties of skin using diffuse reflectance spectroscopy

et al. 2015

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Diffuse reflectance spectroscopy characterizes composition and structure of tissues by determining their scattering and absorption properties. We have developed in our laboratory a low-cost spatially resolved diffuse reflectance spectroscopy instrument. We present in this study some results showing how to adapt this technology on multi-layered tissues. First of all, a method enabling determination of scattering and absorption properties of multi-layered phantoms is described; the adaptation of the initial methodology to focus on deep layers is especially detailed. Then some preliminary results obtained on a panel of volunteer's redness faces are presented.

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Diffuse reflectance spectroscopy: a clinical study of tuberculin skin tests reading

Cited by 8 publications

References 8 publications

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

Non-contact quantitative diffuse reflectance spectroscopy

Accessing deep optical properties of skin using diffuse reflectance spectroscopy

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