Diffuse Panbronchiolitis in North America

Randhawa, Parmjeet; Hoagland, Melissa Heller; Yousem, Samuel A.

doi:10.1097/00000478-199101000-00005

Cited by 66 publications

(6 citation statements)

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“…A review of the cases in the literature of DPB in non-Japanese subjects revealed a total of 19 Mongoloid (14 Chinese and five Koreans) and 13 non-Mongoloid cases who generally had not been systematically evaluated 4-810 12 13 16-18 27 Of these, HLA-B54 was detected in only two cases in the former and either not checked or not detected in the latter group. In addition, raised levels of cold haemagglutinin were found in two Hispanic patients but not in the rest of the aforementioned 32 cases 5…”

Section: Discussionmentioning

confidence: 99%

Clinical profiles of Chinese patients with diffuse panbronchiolitis

Tsang

Ooi

et al. 1998

Thorax

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Background-DiVuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in seven Chinese patients is described and the clinical profiles compared with those of Japanese subjects. Methods-Seven Chinese patients (three women; mean (SD) age 48(18.6) years, all never smokers) who attended a teaching hospital centre and fulfilled the diagnostic criteria for DPB were assessed prospectively for clinical, radiological, lung function, microbiological, and other "characteristic" laboratory parameters. Results-Lungfunction assessment showed a typical obstructive pattern (n = 5) and air trapping (n = 7). Typical bronchiolar infiltration by lymphocytes and plasma cells and accumulation of foamy macrophages in the intraluminal tissue were detected in open lung biopsy specimens (n = 2). Chest radiographs and high resolution computed tomographic scans revealed hyperinflation, diVuse nodules, bronchial thickening and dilatation, peripheral hypoattenuation, and bronchiolectasis. Radiological improvement, manifest as a reduction in nodular density and bronchial thickening, and persistence of other abnormalities such as air trapping were not accurately depicted by the classical Nakata or Akira classifications. The other "characteristic" features such as HLA-B54, IgG subclass deficiency, raised CD4/CD8 T lymphocyte ratio, cold haemagglutinaemia, raised IgA, IgG, and rheumatoid factor were not present. Treatment with erythromycin led to excellent responses in symptoms, lung function indices, and the radiological picture. A review of the non-Japanese cases in the literature reveals that this absence of typical "additional features" in DPB might also be applicable to non-Japanese patients. Conclusions-We report the only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients. (Thorax 1998;53:274-280)

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Section: Discussionmentioning

confidence: 99%

Clinical profiles of Chinese patients with diffuse panbronchiolitis

Tsang

Ooi

et al. 1998

Thorax

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“…However, the pathogenesis of the disease is still unknown. Although DPB was recognized internationally (4)(5)(6)(7)(8), cases of DPB have been noted predominately in East Asians, such as Japanese, Chinese, and Koreans (9). Familial cases of DPB (10) and the disease's feature of predominantly affecting East Asians suggest that the disease might be associated with genetic and racial susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Differential Association between HLA and Diffuse Panbronchiolitis in Northern and Southern Chinese

Chen

Kang

Wu³

et al. 2012

Intern. Med.

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“…Only sporadic case reports and a few short series describing DPB have been reported in Western populations (3)(4)(5)(6). The histopathologic feature of DPB is chronic inflammation centered first on respiratory bronchioles and surrounding alveoli and then on distal membranous bronchioles with mural infiltration of lymphocytes, plasma cells, and histiocytes, and intraluminal aggregates of neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Macrolide Antibiotic Therapy in the Treatment of Chronic Small Airway Disease Clinically Mimicking Diffuse Panbronchiolitis

et al. 2005

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Objective In the current studies, we investigated the clinical effects of long-term macrolide antibiotic therapy for patients with chronic small airway disease (CAD) that clinically and radiologically mimics but is pathologically distinct from diffuse panbronchiolitis (DPB).Patients and Methods Twenty-one Japanese patients were selected on the basis of clinical criteria for DPB and were categorized as DPB or CAD following histological evaluation of surgical lung biopsies. All patients received long-term macrolide therapy, and therapeutic results were compared for the DPB and CAD groups.Results Clinical, laboratory, radiological, and bacterial features, as well as neutrophilia in bronchoalveolar lavage fluid were strikingly similar in both groups. Longterm treatment with macrolides improved the clinical symptoms and PaO2 in both groups. There was a significant improvement in forced expiratory volume in one second (FEV1), vital capacity (VC), and %VC in patients with DPB but not in patients with CAD. Neutrophilia in bronchoalveolar lavage fluid was also reduced following therapy in DPB patients but was refractory in CAD patients.Conclusion Based on the different responses to macrolides, CAD might be associated with conditions distinct from those of DPB. Nevertheless, low-dose macrolide therapy may be applied in CAD to achieve clinical improvement, such as in respiratory symptoms and PaO2.

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Diffuse Panbronchiolitis in North America

Cited by 66 publications

References 0 publications

Clinical profiles of Chinese patients with diffuse panbronchiolitis

Clinical profiles of Chinese patients with diffuse panbronchiolitis

Differential Association between HLA and Diffuse Panbronchiolitis in Northern and Southern Chinese

Long-Term Macrolide Antibiotic Therapy in the Treatment of Chronic Small Airway Disease Clinically Mimicking Diffuse Panbronchiolitis

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