Differential Association between HLA and Diffuse Panbronchiolitis in Northern and Southern Chinese

Chen, Yu; Kang, Jian; Wu, Min; Azuma, Arata; Zhao, Li

doi:10.2169/internalmedicine.51.6483

Cited by 3 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that DPB is closely related to HLA-A11 and HLA-B54. 2 However, the two sisters with DPB were both negative for HLA-A11 and HLA-B54, but positive for HLA-A24 and HLA-B13. Interestingly, their father and younger brother were positive for HLA-A11, but there was no evidence of diffuse panbronchiolitis.…”

Section: Discussionmentioning

confidence: 96%

“…1 It is a rare complex genetic disease that mainly affects East Asians and is strongly associated with the class I human leukocyte antigen (HLA)-B54 in Japanese and HLA-A11 in Koreans. 2 This uneven distribution is suspected to be highly associated with genetic predisposition located between HLA-A and HLA-B loci. More than 80% of the patients have chronic sinusitis, which usually precedes the lower respiratory tract symptoms by years.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Gong

Jiang

et al. 2020

Chron Respir Dis

View full text Add to dashboard Cite

Diffuse panbronchiolitis (DPB) is a chronic diffuse airway inflammatory disease, which is strongly associated with the class I human leukocyte antigen (HLA) alleles. Here, we report a pair of sisters who have been suffering from chronic cough, expectoration and wheezing for many years. They were previously misdiagnosed as chronic bronchitis and bronchial asthma, and were recently diagnosed as diffuse panbronchiolitis. The 36-year-old elder sister suffered from diffuse panbronchiolitis complicated with pulmonary tuberculosis. The 30-year-old younger sister suffered from diffuse panbronchiolitis complicated with bronchial asthma and bronchiectasis. We have performed HLA genotyping research on the two sisters, their parents and younger brother. The results showed that all family members were positive for HLA-A24 and HLA-B13. The younger sister and mother were positive for HLA-A2. The younger brother and father were positive for HLA-A11. We suspect that the two sisters’ disease susceptibility may be caused by their parents’ consanguineous marriage. In this study, we reported the clinical characteristics of the two sisters with diffuse panbronchiolitis and shared the associated HLA genotyping results of this family cluster, hoping to provide reference for the etiology, diagnosis and treatment of this disease.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Gong

Jiang

et al. 2020

Chron Respir Dis

View full text Add to dashboard Cite

show abstract

“…Infections and immune conditions associated with HLA-A11 expression have been investigated; these include familial otosclerosis, pulmonary tuberculosis, leprosy, cytomegalovirus infection with epilepsy, osteosarcoma, antidepressant-induced hepatitis, steroid-responsive nephrotic syndrome, and diffuse panbronchiolitis. [19][20][21][22][23][24][25][26] It has been proposed that immunologic responses are initiated under certain conditions by general or unique HLA determinants in susceptible A11 carriers. 27 The presence of certain HLA antigens renders patients susceptible to MD; ethnic differences in HLA-associated genes may partially explain the variations in MD incidence among populations.…”

Section: Discussionmentioning

confidence: 99%

“…For example, HLA-B54 and HLA-A11 were positively associated with diffuse panbronchiolitis in Northern and Southern Chinese, respectively. 26 Therefore, it is reasonable that DRB1*09 should be protective in a Beijing Han population (Northern Chinese) with MD but that A*11 should increase MD susceptibility in a Taiwanese population (East-Southern Chinese).…”

Section: Discussionmentioning

confidence: 99%

Association of Ménière Disease with Human Leukocyte Antigen in Taiwanese Population

Chan

et al. 2018

Ear Nose Throat J

View full text Add to dashboard Cite

The etiology of Ménière disease (MD) is multifactorial; genetic factors seem to play an important role. The associations between MD and human leukocyte antigen (HLA) status have been studied previously in several populations and have shown that the HLA alleles imparting susceptibility varied. In the present study, we explored HLA status in Taiwanese patients with definitive MD. HLA was typed via polymerase chain reaction, sequence-specific oligonucleotide genotyping in 35 patients with MD diagnosed using the criteria of the American Academy of Otolaryngology-Head and Neck Surgery and 70 unrelated healthy controls. HLA allele association tests were used to evaluate differences in allelic frequencies between the patients and controls. The allelic frequency of HLA-A*11 was significantly greater in MD patients than in controls (52.9 vs. 31.4%, odds ratio: 2.45, 95% confidence interval: 1.4 to 4.4, p = 0.004, p corrected = 0.03). Thus, A*11 may be a useful HLA biomarker in Taiwanese patients with MD. Further larger-scale studies are required.

show abstract

“…Similarly to Japanese population, this study with Koreans identified HLA-DR*13 as a protective genetic marker against DPB. The rarity of the disease and the subsequent studies low sample number adds great difficulties to obtain conclusive results in others than Japanese population, but positive association with DPB were confirmed in Chinese patients for HLA-A*11 and -B*54 [124,125,126] .…”

Section: Idiopathic Bronchiectasismentioning

confidence: 99%

HLA Loci and Respiratory Infectious Diseases

Spínola

2016

Journal of Respiratory Research

View full text Add to dashboard Cite

The HLA system harbour a wide set of genes that plays an important role in the regulation and action of the immune system against invading pathogens, making them natural candidates for research on the genetic susceptibility for respiratory infections. Thus, along past decades, this topic has been subject to intense research and, consequently, several alleles of those loci have been implicated in the ability, more or less effective, to tackle and control invading pathogens in the respiratory system. Current editorial introduce, revise, summarize and comment the major advances in the role of HLA genes for the development of, and protection against, respiratory infectious disease. A general picture is drawn and new challenges on the field are relocated, especially those that might enlighten respiratory diseases aetiology and, thus, contribute in advances for diagnosis and treatment.

show abstract

Differential Association between HLA and Diffuse Panbronchiolitis in Northern and Southern Chinese

Abstract: HLA-B54 and HLA-A11 were positively associated with DPB in Northern and Southern Chinese, respectively. Population substructure may impact the genetic predisposition of DPB in China.

Cited by 3 publications

References 27 publications

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage family and literature review

Association of Ménière Disease with Human Leukocyte Antigen in Taiwanese Population

HLA Loci and Respiratory Infectious Diseases

Contact Info

Product

Resources

About