Diffuse neurofibroma of the scalp presenting as circumscribed alopecic patch

Kumar, B C Sharath; Gopal, MG; Talwar, Anjana; Ramesh, M

doi:10.4103/0974-7753.66919

Cited by 15 publications

(10 citation statements)

References 5 publications

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“… 4 - 8 Intracranial extension of the extracranial variety of this tumor has rarely been reported 7 and malignant transformation is believed to be rare, however pain and enlargement may proclaim it. 2 Although Megahed and Hassel et al reported higher association rates, it is estimated that about 10% of these tumors are associated with NF 2 , 4 , 5 , 8 , 9 Some authors attribute the lower estimated incidence of NF-1 to the young age of patients with diffuse neurofibroma, which often precludes a reliable diagnosis of NF-1. 3 …”

Section: Discussionmentioning

confidence: 99%

Diffuse neurofibroma - an uncommon cause of alopecia

Macias

Rafael

Fernandes

et al. 2013

An. Bras. Dermatol.

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Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

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Section: Discussionmentioning

confidence: 99%

Diffuse neurofibroma - an uncommon cause of alopecia

Macias

Rafael

Fernandes

et al. 2013

An. Bras. Dermatol.

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“…Diffuse neurofibromas usually manifest as diffuse dermal plaque-like swellings in the head and neck regions resulting in enlargement of the affected tissue [ 7 ]. These are uncommon with less than 10% presenting as diffuse neurofibromas in neurofibromatosis type 1 [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Ankle Swelling in Patients With Type 1 Neurofibromatosis: A Report of Two Cases With Rare Presentation of Common Genodermatosis

Thomas¹,

Balasundaram²,

James³

et al. 2022

Cureus

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Neurofibromatosis type 1 is characterized by multiple cutaneous neurofibromas of varying sizes along with skeletal, neurologic, and ophthalmic features. Solitary swellings in neurofibromatosis type 1 are not commonly encountered except in the form of plexiform neurofibromas. We report two cases with neurofibromatosis type 1 presenting with solitary swelling in the ankles which were proven to be the diffuse type of neurofibroma, radiologically and histopathologically. Diffuse type neurofibroma presenting as ankle swelling in type 1 neurofibromatosis has not been reported before.

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“…Intracranial extension of the extracranial variety of this tumor has rarely been described [4]. Although Kumar et al [5] reported higher association rates, it is estimated that about 10% of these tumors are associated with NF-1. On histopathological examination, diffuse NFs are ill-defined tumors that diffusely infiltrate the dermis and subcutaneous tissue, often extending along connective tissue septa, without destroying the normal structures.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Neurofibroma: An Uncommon Cause of Alopecia

Lee¹,

Chang²,

Fu³

2020

Skin Appendage Disord

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Skin biopsy showed neurofibroma (NF) occupying the entire dermis, and "pushing" hair follicles towards the upper dermis may be a clue to alopecia. Established Facts• Diffuse NF is a rare form of NF reported to occur primarily in children and young adults. It generally presents as a variably sized area of marked dermal and subcutaneous thickening, most often in the head and neck regions. • The mechanism of NF-associated alopecia is unknown. AbstractAlopecia (hair loss) is reported to be associated with infection, genetics, hormonal changes, drugs, or inflammation. The most frequent causes of hair loss in pediatric patients include tinea capitis, alopecia areata, traction alopecia, and trichotillomania. In the adult population, causes to be considered are alopecia areata and hair loss associated with systemic disease and hormonal influence. The clinician must be able to separate the types and causes of hair loss into those that reflect primary dermatologic conditions and those that represent a reaction to systemic disease. Benign cutaneous tumors have also been known to develop alopecia via occupying the place for hair follicles or tumor-in-duced inflammatory responses. However, the mechanism of alopecia by neurofibroma (NF) has not been well investigated. We present a 32-year-old patient who developed scalp plaque with alopecia within 6 years. He denies any itching or pain in the area, and has not tried any treatments. In this study, the unusual association between NF and alopecia is shown.

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Diffuse neurofibroma of the scalp presenting as circumscribed alopecic patch

Cited by 15 publications

References 5 publications

Diffuse neurofibroma - an uncommon cause of alopecia

Diffuse neurofibroma - an uncommon cause of alopecia

Ankle Swelling in Patients With Type 1 Neurofibromatosis: A Report of Two Cases With Rare Presentation of Common Genodermatosis

Diffuse Neurofibroma: An Uncommon Cause of Alopecia

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