Diffuse neurofibroma - an uncommon cause of alopecia

Macias, Vasco Coelho; Rafael, Margarida; Fernandes, Cândida; Rosa, José

doi:10.1590/abd1806-4841.20132170

Cited by 15 publications

(26 citation statements)

References 10 publications

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“…These findings were seen in our case on second look of the original specimen (Fig. 3) 15]. Wagner-Meissner corpuscles are specific, but not a sensitive finding [9] (Fig.…”

Section: Discussionsupporting

confidence: 60%

Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum

et al. 2014

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Diffuse infiltrative neurofibroma is a rare clinical entity that can pose a diagnostic challenge not only due to its rarity but also due to its varied clinical, radiological, and histological features. Our case illustrates how this entity may be misdiagnosed on clinical and pathological examination. Radiological imaging plays a critical and collaborative role in guiding clinicians and pathologists when faced with this challenging diagnosis.

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“…These findings were seen in our case on second look of the original specimen (Fig. 3) 15]. Wagner-Meissner corpuscles are specific, but not a sensitive finding [9] (Fig.…”

Section: Discussionsupporting

confidence: 60%

Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum

et al. 2014

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“…Given the infiltrative growth pattern and multicentricity of the tumor, clinical recurrences are common, even after complete surgical excision. Because of the recurrence potential, malignant transformation, and NF development possibility, yearly follow-up is recommended [7]. Due to the lack of distinctive clinical characteristics, especially in isolated lesions, it is difficult to diagnose the lesion preoperatively, and such lesions remain largely a histopathologic diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Neurofibroma: An Uncommon Cause of Alopecia

Lee¹,

Chang²,

Fu³

2020

Skin Appendage Disord

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Skin biopsy showed neurofibroma (NF) occupying the entire dermis, and "pushing" hair follicles towards the upper dermis may be a clue to alopecia. Established Facts• Diffuse NF is a rare form of NF reported to occur primarily in children and young adults. It generally presents as a variably sized area of marked dermal and subcutaneous thickening, most often in the head and neck regions. • The mechanism of NF-associated alopecia is unknown. AbstractAlopecia (hair loss) is reported to be associated with infection, genetics, hormonal changes, drugs, or inflammation. The most frequent causes of hair loss in pediatric patients include tinea capitis, alopecia areata, traction alopecia, and trichotillomania. In the adult population, causes to be considered are alopecia areata and hair loss associated with systemic disease and hormonal influence. The clinician must be able to separate the types and causes of hair loss into those that reflect primary dermatologic conditions and those that represent a reaction to systemic disease. Benign cutaneous tumors have also been known to develop alopecia via occupying the place for hair follicles or tumor-in-duced inflammatory responses. However, the mechanism of alopecia by neurofibroma (NF) has not been well investigated. We present a 32-year-old patient who developed scalp plaque with alopecia within 6 years. He denies any itching or pain in the area, and has not tried any treatments. In this study, the unusual association between NF and alopecia is shown.

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“…Diffuse neurofibroma is an ill-defined and infiltrative lesion, usually nondestructive, rarely undergoes malignant change and is most commonly found in the head and neck region. On histopathology, it is composed of spindle-shaped and ovoid cells with occasional Meissner bodies, and is S100 immunoreactive [6].…”

Section: Discussionmentioning

confidence: 99%

Post Traumatic Diffuse Neurofibroma in the Foot: An Unusual Presentation

Nasser¹,

Alsaad²,

Awad³

et al. 2018

TOORTHJ

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Background: Neurofibromas are benign peripheral nerve sheath tumors that present as solitary or multiple lesions. They can present alone or as part of the disease process called neurofibromatosis type 1. The etiology behind solitary neurofibromas is still poorly understood, however, trauma has been proposed to be a possible cause. Methods: We present a rare case of a 23-year-old male, without any known medical history, who fell and injured his left foot 3 years prior to presentation. He was treated conservatively at that time and presented to Bahrain Defence Force hospital complaining of a progressive painless swelling in his left forefoot post trauma. Results: The patient underwent imaging studies, which misdiagnosed the lesion as a possible lymphangioma, haemangioma, or a chronic inflammatory swelling. An excisional biopsy was taken, and the pathology specimen proved the lesion to be a diffuse neurofibroma. Conclusion: Trauma may possibly be a predisposing factor behind the development of solitary diffuse neurofibromas in patients that are not known to have neurofibromatosis. Further studies should be conducted to prove whether or not trauma is a predisposing factor for the development of solitary neurofibromas.

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Diffuse neurofibroma - an uncommon cause of alopecia

Cited by 15 publications

References 10 publications

Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum

Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum

Diffuse Neurofibroma: An Uncommon Cause of Alopecia

Post Traumatic Diffuse Neurofibroma in the Foot: An Unusual Presentation

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