Diffuse lipomatosis of thyroid gland

Arslan, Adem; Alic, B.; Uzunlar, Ali Kemal; Büyükbayram, Hüseyin; Sarı, İbrahim

doi:10.1016/s0385-8146(98)00049-2

Cited by 19 publications

(17 citation statements)

References 5 publications

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“…In keeping with previous reports, the patient remained euthyroid despite the dramatic loss of thyroid follicular architecture. 5,8 Conclusion Extensive fatty infiltration of the entire thyroid gland is a very rare finding, and in the current patient was present together with amyloid protein deposition. This is the first report of these two phenomena occurring together in a patient with AA amyloidosis.…”

Section: Discussionmentioning

confidence: 54%

Diffuse lipomatosis of the thyroid with amyloid deposition

Jacques

Stearns

2013

J. Laryngol. Otol.

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To our best knowledge, this patient represents the first reported case of diffuse lipomatosis of the thyroid gland causing goitre in a patient with AA amyloidosis. The presence of amyloid protein within the thyroid was not sufficient to cause enlargement per se, and was therefore of unclear significance. Together with previous reports of the concurrent deposition of amyloid and fat, this case raises questions as to the relationship between these two phenomena.

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Section: Discussionmentioning

confidence: 54%

Diffuse lipomatosis of the thyroid with amyloid deposition

Jacques

Stearns

2013

J. Laryngol. Otol.

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“…Some consider it a developmental anomaly, because of entrapment of fat cells before the development of the capsule of thyroid explaining the heterotopic nests of fat in thyroid. (5,6,7) Some consider it to be metaplastic change of fibroblasts because of chronic hypoxia. (8,9) Diffuse fatty infiltration of the thyroid tissue on gross inspection is called diffuse lipomatosis of thyroid.…”

Section: Discussionmentioning

confidence: 99%

“…(8,9) Diffuse fatty infiltration of the thyroid tissue on gross inspection is called diffuse lipomatosis of thyroid. (7) Lipomatosis may manifest as congenital swelling. (3) Aspiration cytology would reveal mixture of adipocytes and follicular cells of thyroid and thus can lead to preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Lipomatosis of Thyroid Gland Masquerading as Malignancy: A Case Report

Nar¹,

Bawa²,

Mishra³

et al. 2016

jemds

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Infiltration of the thyroid gland by adipose tissue is a very rare phenomenon. It is generally seen as a separate entity with diffuse presence of mature fat cells called Diffuse Lipomatosis of thyroid. We are presenting a case of 52-year-old male having thyroid swelling, which was causing respiratory obstructive symptoms and hoarseness of voice, mimicking malignancy. Patient was taken up for Total Thyroidectomy. Intraoperatively, lipomatous tumour-like tissue was found replacing the thyroid gland. Histopathological examination of the specimen showed abundant mature fat cells with thyroid follicles and also scanty amount of amyloid material.

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“…However, in normal thyroid glands, although small amounts of fat cells are occasionally found near the capsule and around the vessels, the presence of large amounts of adipose tissue is rare. Mature fat cells have been described in adenolipoma 1-14 and adenolipomatosis [15][16][17][18][19] of the thyroid, and in amyloid goiters. 9,20,21 Adenolipomatosis appears to be a type of diffuse fatty infiltration into the struma, whereas adenolipomas of the thyroid are completely surrounded by a fibrous capsule, which differentiates them from diffuse lipomatosis.…”

Section: Discussionmentioning

confidence: 99%

Adenolipoma of the Thyroid Gland: Report of a Case

et al. 2004

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We report a case of adenolipoma of the thyroid gland, which is very unusual because thyroid adenoma rarely contains mature adipose tissue. A 55-year-old Japanese woman presented with a 1-month history of a neck mass. A blinded fine-needle aspiration biopsy showed benign follicular cells with no adipose cells, and we performed a left hemithyroidectomy. The specimen measured 7.0 x 4.4 cm and weighed 59.9 g. The cut surface of the tumor revealed a solid yellowish mass, and hematoxylin-eosin staining showed that the solid tumor was well separated from the adjacent thyroid tissue by a thin fibrous capsule. The tumor was found to be follicular adenoma composed of epithelial cells arranged in monotonous microfollicular patterns, intermingled with mature adipose tissue. No adipose tissue was found outside the tumor, and there were no signs of amyloid deposits in the tumor or adjacent thyroid tissue. The pathological diagnosis was adenolipoma of the thyroid gland. We discuss the pathogenesis of this entity and review the previously documented cases.

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Diffuse lipomatosis of thyroid gland

Cited by 19 publications

References 5 publications

Diffuse lipomatosis of the thyroid with amyloid deposition

Diffuse lipomatosis of the thyroid with amyloid deposition

Diffuse Lipomatosis of Thyroid Gland Masquerading as Malignancy: A Case Report

Adenolipoma of the Thyroid Gland: Report of a Case

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