Diffuse Lipomatosis of the Thyroid Gland

Lo, Ryan; Donaldson, Carolyn K.

doi:10.1097/ruq.0b013e3182a0ad95

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…CT scans show an enlarged thyroid with well-defined limits and diffuse infiltration by fat with negative density in the range of adipose tissue (−30 to −40 Hounsfield units). Extension outside the thyroid bed can involve the upper mediastinum and the retropharyngeal compartment, compressing or displacing the surrounding airway and vascular structures (8).…”

Section: Discussionmentioning

confidence: 99%

Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Bell

Sosa

Jaén

et al. 2016

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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SummaryThyroid lipomatosis is a rare disease, as a total of 20 cases have been described in the literature. It is characterized by diffuse infiltration of the stroma by mature adipose tissue and by progressive growth that produces different degrees of compressive symptoms. Our aim is to present the case of a 36-year-old woman who consulted because of dyspnea caused by a multinodular goiter. She underwent surgery with the presumptive diagnosis of a malignant neoplasia, but the pathological examination of the surgical specimen established the diagnosis of thyroid lipomatosis.Learning points Thyroid lipomatosis is a rare, benign disease characterized by diffuse infiltration of the stroma by mature adipose tissue.The pathophysiology of diffuse proliferation of adipose tissue in the thyroid gland is unclear.Thyroid lipomatosis is clinically manifested by a progressive enlargement of the thyroid that can involve the airway and/or upper gastrointestinal tract, producing dyspnea, dysphagia, and changes in the voice.Given the rapid growth of the lesion, the two main differential diagnoses are anaplastic carcinoma and thyroid lymphoma.Imaging studies may suggest a differential diagnosis, but a definitive diagnosis generally requires histopathological confirmation after a thyroidectomy.

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Section: Discussionmentioning

confidence: 99%

Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Bell

Sosa

Jaén

et al. 2016

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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“…Radiological studies were not diagnostic, but the ultrasound may reveal enlargement of the thyroid with diffuse increase in the echogenicity and attenuation of sound typical of fat [10], Computerized tomography of the thyroid may reveal low attenuation components with negative Hounsfield units [11].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with this condition are also often euthyroid as seen in our patient [1] and are usually asymptomatic until the thyroid causes mass effect in the neck. Most patients with this condition elect for a thyroidectomy and therefore the natural history of this rare entity is unknown [10].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Lipomatosis of Thyroid—Case Report

Jahid¹,

Amine²,

Chad³

2018

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Diffuse lipomatosis of thyroid gland is very rare disease, characterized by diffuse proliferation of adipose tissue in the thyroid gland, the pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a case of a 55-year-old female who presented 6 months ago a dysphonia, ultrasound of the neck revealed the presence diffuse goiter with heterogeneous echogenicity, her thyroid hormone levels were normal, thyroid isotope scanning showed heterogeneous uptake of radioactivity and coexistence of cold and hot nodules. The patient underwent total thyroidectomy. Histological study concluded to the diagnosis of diffuse lipomatosis of thyroid gland.

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“…For example, there is no predominance by sex (56% male), its occurrence is mostly in middle-aged adults (mean age 51 years; range 44-57 years) and it is usually associated with systemic conditions like chronic kidney failure (39%) and amyloidosis (17%). 3,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Thyrolipomatosis is a benign condition because the fatty infiltration of the thyroid gland is diffuse but non-neoplastic. However, some case reports suggest the coexistence of thyrolipomatosis with malignant neoplasms such as papillary thyroid carcinoma or colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

Paz-Ibarra,

Concepción-Zavaleta,

Mendoza-Quispe

et al. 2023

European Endocrinology

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Thyrolipomatosis, a diffuse non-neoplastic infiltration of fatty tissue in the thyroid gland, is an extremely rare condition with only about 30 cases reported worldwide. A few of these cases report the concurrency of thyrolipomatosis and malignant neoplasms in the thyroid or colon, but never with tongue cancer. A 44-year-old female patient with an infiltrative tongue mass suggestive of carcinoma presented for an outpatient consultation. Cervical imaging revealed multiple lymphadenopathies and a multinodular goitre with diffuse fatty infiltration, suggestive of thyrolipomatosis. Surgical intervention included partial resection of the tongue and thyroid (left hemiglossectomy and right hemithyroidectomy, respectively) and lymphadenectomy. The thyroid specimen showed diffuse fat metaplasia of the stromal thyroid tissue, confirming incidental thyrolipomatosis. During post-operative follow-up, the patient presented with recurrence of squamous cell carcinoma as indicated by new right-sided thyroid nodules, left-sided lymphadenopathies with confirmatory biopsy, and a growing neck mass that became infected. The patient developed septic shock and later died. Thyrolipomatosis causes thyroid swelling and can be clinically detected as goitres or as an incidental finding. Diagnosis is suggested by cervical imaging (ultrasonography, computed tomography or magnetic resonance), but confirmation is histological after thyroidectomy. Although thyrolipomatosis is benign, it could develop concurrently with neoplastic diseases, especially on embryologically related tissues (e.g. thyroid and tongue). This case report is the first in the literature describing the coexistence between thyrolipomatosis and tongue cancer in an adult Peruvian patient.

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Diffuse Lipomatosis of the Thyroid Gland

Cited by 5 publications

References 3 publications

Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Thyroid lipomatosis in a 36-year-old patient with rheumatoid arthritis and a kidney transplant

Diffuse Lipomatosis of Thyroid—Case Report

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

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