Diffuse Large B-cell Lymphoma with Massive Portal Vein Tumor Thrombosis in a Patient with Alcoholic Cirrhosis: A Case Report and Literature Review

Natsuizaka, Mitsuteru; Kudo, Mineo; Suzuki, Motofumi; Takano, Masatoshi; Tsuyuguchi, Masako; Kawamura, Naoshi; Noguchi, Sanai; Wada, Akinori; Nakata, Masao; Ogasawara, M.; Kiyama, Yoshio; Asaka, Masahiro; Kasai, Masaharu

doi:10.2169/internalmedicine.48.1648

Cited by 16 publications

(9 citation statements)

References 15 publications

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“…This case describes an unusual etiology of esophageal variceal bleeding secondary to noncirrhotic portal hypertension from an extensive PVTT caused by an NHL malignancy surrounding the celiac trunk. Current medical literature yields only seven previously reported cases of NHL-associated PVTT, of which four were specifically DLBCL [4][5][6][7][8][9][10]. This makes our case the eighth reported presentation of NHL-associated PVTT in medical literature, and the fifth specifically associated with DLBCL.…”

Section: Discussionmentioning

confidence: 85%

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

Sieloff

Garg

Goyal

et al. 2020

Cureus

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A 60-year-old woman presented with six months of abdominal pain, weight loss and diarrhea for which she underwent bidirectional endoscopies that were unremarkable. Over the next two weeks, she developed non-cirrhotic portal hypertension and presented with esophageal variceal bleeding. A diffuse large B-cell lymphoma encircling her celiac axis with a tumor thrombosis of the superior mesenteric, splenic and portal veins was found to be the cause of her portal hypertension. An esophagogastroduodenoscopy (EGD) was performed to control her variceal bleeding. She was started on R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy and after three cycles her symptoms have subsided, and a CT scan has shown shrinking mesenteric lymphadenopathy.

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Section: Discussionmentioning

confidence: 85%

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

Sieloff

Garg

Goyal

et al. 2020

Cureus

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“…Generally spermatic cord lymphomas are known to have a poor prognosis but recent case studies show a good response to treatment ( 32 ). The patients were treated aggressively with multiple cycles of combination chemotherapy which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone with some variation and additional therapy determined per case ( 32 , 34 , 35 ).…”

Section: Malignant Neoplasmsmentioning

confidence: 99%

Neoplastic diseases of the spermatic cord: an overview of pathological features, evaluation, and management

Dagur¹,

Gandhi²,

Kapadia³

et al. 2017

Transl. Androl. Urol.

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Extracellular tumors found with the spermatic cord, known as neoplasms, are usually identified to be benign. However, the accurate and timely diagnosis of spermatic cord masses is highly crucial, especially when most results are often overlooked or unclear. In this review, we discuss the anatomy and embryology of the spermatic cord. Upon rooting these fundamental concepts, we discuss an array of benign and malignant neoplastic tumors, including their origin, pathological features, clinical evaluation and management, as well as other case-specific characteristics of unique presentation. Many of these neoplasms are based on local neurological, vascular, muscular, bone, soft tissue, or lymphatic origin, while others have metastasized from particular areas of the body.

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“…[4][5][6][7][8][9][10][11][12] However, except for elevated FDG activity, the findings of tumor thrombus at different blood vessels are quite variable. [4][5][6][7][8][9][10][11][12] In our case, we describe a different pattern of tumor thrombus in the entire length of left ovarian arteries and veins, which appears similar to the findings of retroperitoneal fibrosis on FDG PET/CT as previously described. [13][14][15][16][17][18] …”

Section: Figurementioning

confidence: 99%

FDG PET/CT Appearance of Tumor Thrombus of Ovarian Vessels Masquerading as Retroperitoneal Fibrosis

Luo

Feng²,

Li³

2015

Clinical Nuclear Medicine

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A 23-year-old woman with recurrent uterine endometrial stromal sarcoma underwent FDG PET/CT, which showed pelvic recurrence and multiple pulmonary metastases. In addition, increased activity in a vertical soft tissue mass along the left ureter was noted, which appears similar to retroperitoneal fibrosis on PET/CT images. However, pathological examination demonstrated that the elevated FDG activity in this mass was a result of tumor thrombus from endometrial stromal sarcoma in the left ovarian arteries and veins.

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Diffuse Large B-cell Lymphoma with Massive Portal Vein Tumor Thrombosis in a Patient with Alcoholic Cirrhosis: A Case Report and Literature Review

Abstract: We describe a case of diffuse large B-cell

Cited by 16 publications

References 15 publications

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

Neoplastic diseases of the spermatic cord: an overview of pathological features, evaluation, and management

FDG PET/CT Appearance of Tumor Thrombus of Ovarian Vessels Masquerading as Retroperitoneal Fibrosis

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